ClinVar Miner

Variants with conflicting interpretations, by significance

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
3953409 382558 256 99151 79236 810 19632 183195

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign affects association association not found drug response protective other
pathogenic 183 33610 8607 662 530 56 19 3 93 5 140
likely pathogenic 33610 33 13571 683 347 30 11 1 48 4 78
uncertain significance 8607 13571 44 71260 16532 33 24 0 59 7 195
likely benign 662 683 71260 1 65605 11 20 0 61 10 121
benign 530 347 16532 65605 0 27 42 0 79 20 63
affects 56 30 33 11 27 0 3 0 0 0 1
association 19 11 24 20 42 3 1 0 4 1 4
association not found 3 1 0 0 0 0 0 0 0 0 0
drug response 93 48 59 61 79 0 4 0 0 0 23
protective 5 4 7 10 20 0 1 0 0 0 1
other 140 78 195 121 63 1 4 0 23 1 0

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