ClinVar Miner

Variants in gene TRPM4 with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
1924 234 0 34 75 0 2 100

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 0 1 1 0
likely pathogenic 0 0 1 0 0
uncertain significance 1 1 0 65 16
likely benign 1 0 65 0 34
benign 0 0 16 34 0

All variants with conflicting interpretations #

Total variants: 100
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_017636.4(TRPM4):c.2934T>C (p.Ile978=) rs35516880 0.02629
NM_017636.4(TRPM4):c.449-10G>A rs78444754 0.02545
NM_017636.4(TRPM4):c.783G>A (p.Lys261=) rs111930830 0.01878
NM_017636.4(TRPM4):c.3641-19C>G rs7256050 0.01687
NM_017636.4(TRPM4):c.322C>T (p.Arg108Cys) rs115335683 0.01074
NM_017636.4(TRPM4):c.3082C>T (p.Leu1028=) rs79286201 0.01042
NM_017636.4(TRPM4):c.448+6C>T rs78051297 0.01005
NM_017636.4(TRPM4):c.2953+15G>A rs115274216 0.00798
NM_017636.4(TRPM4):c.2619C>T (p.Thr873=) rs144544237 0.00790
NM_017636.4(TRPM4):c.306T>G (p.Val102=) rs111783027 0.00672
NM_017636.4(TRPM4):c.301G>A (p.Ala101Thr) rs113984787 0.00662
NM_017636.4(TRPM4):c.755G>A (p.Arg252His) rs146564314 0.00453
NM_017636.4(TRPM4):c.449-14C>T rs112328642 0.00433
NM_017636.4(TRPM4):c.618G>A (p.Ser206=) rs142788545 0.00422
NM_017636.4(TRPM4):c.870C>T (p.Asn290=) rs141997826 0.00389
NM_017636.4(TRPM4):c.1682A>C (p.Asp561Ala) rs56355369 0.00371
NM_017636.4(TRPM4):c.3611C>T (p.Pro1204Leu) rs150391806 0.00310
NM_017636.4(TRPM4):c.1368C>G (p.Thr456=) rs56118173 0.00274
NC_000019.10:g.49157760G>T rs112085495 0.00258
NM_017636.4(TRPM4):c.3427A>G (p.Ser1143Gly) rs138603244 0.00198
NM_017636.4(TRPM4):c.1575G>A (p.Trp525Ter) rs71352737 0.00168
NM_017636.4(TRPM4):c.2209G>A (p.Gly737Arg) rs145847114 0.00165
NM_017636.4(TRPM4):c.1873+13C>G rs184297107 0.00145
NM_017636.4(TRPM4):c.988G>A (p.Glu330Lys) rs145771389 0.00113
NM_017636.4(TRPM4):c.2740A>T (p.Lys914Ter) rs140799936 0.00094
NM_017636.4(TRPM4):c.1164G>A (p.Ser388=) rs144201184 0.00090
NM_017636.4(TRPM4):c.1376G>A (p.Arg459His) rs142312281 0.00086
NM_017636.4(TRPM4):c.2561A>G (p.Gln854Arg) rs172155862 0.00076
NM_017636.4(TRPM4):c.2531G>A (p.Gly844Asp) rs200038418 0.00064
NM_017636.4(TRPM4):c.2674C>T (p.Arg892Cys) rs147854826 0.00047
NM_017636.4(TRPM4):c.342C>G (p.Ala114=) rs144434701 0.00044
NM_017636.4(TRPM4):c.2254C>T (p.Gln752Ter) rs769917929 0.00041
NM_017636.4(TRPM4):c.308A>G (p.Tyr103Cys) rs144781529 0.00039
NM_017636.4(TRPM4):c.1242T>C (p.Phe414=) rs200633475 0.00031
NM_017636.4(TRPM4):c.385G>A (p.Val129Ile) rs372299022 0.00027
NM_017636.4(TRPM4):c.1836G>A (p.Arg612=) rs112589404 0.00023
NM_017636.4(TRPM4):c.1119C>A (p.Phe373Leu) rs141531245 0.00022
NM_017636.4(TRPM4):c.2820G>T (p.Trp940Cys) rs199905308 0.00022
NM_017636.4(TRPM4):c.748C>T (p.Arg250Cys) rs144208673 0.00021
NM_017636.4(TRPM4):c.1874-9C>T rs199805560 0.00020
NM_017636.4(TRPM4):c.1783C>G (p.Leu595Val) rs144812913 0.00018
NM_017636.4(TRPM4):c.1082T>G (p.Leu361Arg) rs148763371 0.00017
NM_017636.4(TRPM4):c.1843C>T (p.Leu615=) rs532994978 0.00017
NM_017636.4(TRPM4):c.742C>T (p.Arg248Cys) rs373749900 0.00014
NM_017636.4(TRPM4):c.754C>T (p.Arg252Cys) rs771728837 0.00014
NM_017636.4(TRPM4):c.3034G>A (p.Val1012Ile) rs182262420 0.00013
NM_017636.4(TRPM4):c.354G>C (p.Val118=) rs566463803 0.00013
NM_017636.4(TRPM4):c.856A>G (p.Thr286Ala) rs151205002 0.00013
NM_017636.4(TRPM4):c.338G>A (p.Arg113His) rs149335121 0.00011
NM_017636.4(TRPM4):c.2954-11T>C rs774806552 0.00010
NM_017636.4(TRPM4):c.2020-4A>C rs369498574 0.00009
NM_017636.4(TRPM4):c.2133-9C>G rs530013543 0.00009
NM_017636.4(TRPM4):c.286C>T (p.Arg96Ter) rs148855956 0.00009
NM_017636.4(TRPM4):c.2984C>T (p.Ser995Leu) rs116547139 0.00008
NM_017636.4(TRPM4):c.2085C>T (p.Leu695=) rs781191851 0.00007
NM_017636.4(TRPM4):c.2508C>T (p.Gly836=) rs750999263 0.00007
NM_017636.4(TRPM4):c.2761G>A (p.Val921Ile) rs377359117 0.00007
NM_017636.4(TRPM4):c.2779-5C>T rs374639233 0.00007
NM_017636.4(TRPM4):c.483C>T (p.Gly161=) rs147157308 0.00007
NM_017636.4(TRPM4):c.657C>T (p.Asp219=) rs373953725 0.00007
NM_017636.4(TRPM4):c.2231A>T (p.Lys744Met) rs569301210 0.00006
NM_017636.4(TRPM4):c.1873+4C>T rs746766318 0.00005
NM_017636.4(TRPM4):c.2712G>T (p.Val904=) rs143447932 0.00005
NM_017636.4(TRPM4):c.3023C>T (p.Ala1008Val) rs756361248 0.00003
NM_017636.4(TRPM4):c.3443T>C (p.Leu1148Pro) rs748665739 0.00003
NM_017636.4(TRPM4):c.3450C>T (p.Arg1150=) rs763372824 0.00003
NM_017636.4(TRPM4):c.1442C>G (p.Ser481Cys) rs200246268 0.00002
NM_017636.4(TRPM4):c.1611G>A (p.Met537Ile) rs372498983 0.00002
NM_017636.4(TRPM4):c.1639C>T (p.Pro547Ser) rs919695965 0.00002
NM_017636.4(TRPM4):c.1885G>A (p.Glu629Lys) rs762104169 0.00002
NM_017636.4(TRPM4):c.3377C>G (p.Ser1126Trp) rs567938424 0.00002
NM_017636.4(TRPM4):c.1070G>A (p.Arg357Gln) rs144328631 0.00001
NM_017636.4(TRPM4):c.1424A>G (p.Asn475Ser) rs768896988 0.00001
NM_017636.4(TRPM4):c.1473A>G (p.Leu491=) rs142739227 0.00001
NM_017636.4(TRPM4):c.1515T>A (p.His505Gln) rs1202211366 0.00001
NM_017636.4(TRPM4):c.2229G>A (p.Glu743=) rs745667706 0.00001
NM_017636.4(TRPM4):c.2358C>T (p.Asn786=) rs886054579 0.00001
NM_017636.4(TRPM4):c.2403G>T (p.Leu801=) rs1455410186 0.00001
NM_017636.4(TRPM4):c.291G>A (p.Thr97=) rs886054576 0.00001
NM_017636.4(TRPM4):c.3489A>G (p.Gly1163=) rs760190293 0.00001
NM_017636.4(TRPM4):c.634C>T (p.Arg212Trp) rs759593186 0.00001
NM_017636.4(TRPM4):c.635G>A (p.Arg212Gln) rs183306159 0.00001
NM_017636.4(TRPM4):c.743G>A (p.Arg248His) rs748954661 0.00001
NM_017636.4(TRPM4):c.837T>C (p.Asp279=) rs373391017 0.00001
NM_017636.4(TRPM4):c.1332C>T (p.Leu444=) rs1229281209
NM_017636.4(TRPM4):c.1380G>T (p.Leu460=) rs145755269
NM_017636.4(TRPM4):c.1459_1494del (p.Lys487_Leu498del) rs878855029
NM_017636.4(TRPM4):c.1687CTT[3] (p.Leu564dup) rs772690187
NM_017636.4(TRPM4):c.1908G>C (p.Val636=) rs950364050
NM_017636.4(TRPM4):c.2154A>C (p.Thr718=) rs370827464
NM_017636.4(TRPM4):c.2214G>A (p.Thr738=) rs1490908470
NM_017636.4(TRPM4):c.2283_2294del (p.759_762CGGR[1]) rs113100797
NM_017636.4(TRPM4):c.243G>A (p.Thr81=) rs375928899
NM_017636.4(TRPM4):c.249C>T (p.Ala83=) rs142270489
NM_017636.4(TRPM4):c.2529G>C (p.Gly843=) rs754769591
NM_017636.4(TRPM4):c.269TCC[1] (p.Leu91del) rs752261543
NM_017636.4(TRPM4):c.2766C>A (p.Ile922=) rs774680517
NM_017636.4(TRPM4):c.2767G>A (p.Val923Met) rs759518981
NM_017636.4(TRPM4):c.2987_3014del (p.Glu996fs) rs765535147
NM_017636.4(TRPM4):c.92+12G>A rs377431946

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. The submitted information has not been verified. If you have questions about the information contained on this website, please see a health care professional.