ClinVar Miner

Variants in gene TG with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
1899 165 0 62 32 0 7 96

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 17 4 0 0
likely pathogenic 17 0 4 0 0
uncertain significance 4 4 0 27 8
likely benign 0 0 27 0 45
benign 0 0 8 45 0

All variants with conflicting interpretations #

Total variants: 96
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_003235.5(TG):c.6395C>T (p.Ser2132Leu) rs61741457 0.04126
NM_003235.5(TG):c.5907G>A (p.Pro1969=) rs17693031 0.03986
NM_003235.5(TG):c.2443G>A (p.Gly815Arg) rs16904774 0.03645
NM_003235.5(TG):c.3933G>A (p.Ala1311=) rs16904786 0.03224
NM_003235.5(TG):c.5186A>C (p.Asp1729Ala) rs61744749 0.02641
NM_003235.5(TG):c.5122A>G (p.Ile1708Val) rs61744679 0.02483
NM_003235.5(TG):c.1332C>T (p.Ile444=) rs61741629 0.02324
NM_003235.5(TG):c.6055+7A>G rs73353474 0.02313
NM_003235.5(TG):c.1821C>T (p.Thr607=) rs61742713 0.02018
NM_003235.5(TG):c.1543C>G (p.Gln515Glu) rs180222 0.01541
NM_003235.5(TG):c.353C>T (p.Pro118Leu) rs114322847 0.01381
NM_003235.5(TG):c.5370A>G (p.Ile1790Met) rs73710715 0.01335
NM_003235.5(TG):c.6272A>G (p.Asp2091Gly) rs61743198 0.01306
NM_003235.5(TG):c.1958G>A (p.Gly653Asp) rs2069548 0.01198
NM_003235.5(TG):c.4365C>T (p.Asp1455=) rs57453794 0.00987
NM_003235.5(TG):c.3187C>A (p.Leu1063Met) rs11992497 0.00903
NM_003235.5(TG):c.199G>A (p.Gly67Ser) rs116340633 0.00871
NM_003235.5(TG):c.2761+14T>C rs76286566 0.00834
NM_003235.5(TG):c.1890A>G (p.Gln630=) rs2228590 0.00831
NM_003235.5(TG):c.1434G>A (p.Val478=) rs116254142 0.00655
NM_003235.5(TG):c.7755-9T>G rs190979363 0.00473
NM_003235.5(TG):c.3313G>A (p.Val1105Ile) rs115670342 0.00416
NM_003235.5(TG):c.2561G>A (p.Arg854Gln) rs115361039 0.00408
NM_003235.5(TG):c.1269C>T (p.Arg423=) rs115916398 0.00385
NM_003235.5(TG):c.325A>G (p.Ile109Val) rs35301433 0.00350
NM_003235.5(TG):c.144C>T (p.Tyr48=) rs114436500 0.00349
NM_003235.5(TG):c.3129C>T (p.His1043=) rs112300885 0.00333
NM_003235.5(TG):c.4484T>C (p.Val1495Ala) rs61740825 0.00330
NM_003235.5(TG):c.7083G>T (p.Ala2361=) rs116723711 0.00239
NM_003235.5(TG):c.2610G>T (p.Gln870His) rs2229843 0.00229
NM_003235.5(TG):c.6200-7T>A rs79724982 0.00228
NM_003235.5(TG):c.7665C>T (p.Arg2555=) rs115139074 0.00214
NM_003235.5(TG):c.3583G>A (p.Gly1195Arg) rs138469414 0.00197
NM_003235.5(TG):c.3665C>T (p.Ser1222Leu) rs12549018 0.00195
NM_003235.5(TG):c.6181G>A (p.Gly2061Arg) rs115436575 0.00195
NM_003235.5(TG):c.3647C>T (p.Pro1216Leu) rs142335537 0.00182
NM_003235.5(TG):c.4529-18T>C rs181011156 0.00151
NM_003235.5(TG):c.6646A>G (p.Ile2216Val) rs138690529 0.00144
NM_003235.5(TG):c.3057C>T (p.Ser1019=) rs116032324 0.00139
NM_003235.5(TG):c.1567T>C (p.Ser523Pro) rs116062097 0.00135
NM_003235.5(TG):c.3999C>G (p.Ile1333Met) rs150728539 0.00129
NM_003235.5(TG):c.4537G>T (p.Asp1513Tyr) rs114305064 0.00128
NM_003235.5(TG):c.2980A>G (p.Ile994Val) rs111363334 0.00127
NM_003235.5(TG):c.5402-16A>T rs190112013 0.00116
NM_003235.5(TG):c.7640T>A (p.Leu2547Gln) rs2979042 0.00107
NM_003235.5(TG):c.7157G>A (p.Arg2386His) rs144905796 0.00098
NM_003235.5(TG):c.3983G>A (p.Arg1328His) rs141146573 0.00086
NM_003235.5(TG):c.4323G>A (p.Ser1441=) rs769654694 0.00079
NM_003235.5(TG):c.229G>A (p.Gly77Ser) rs142698837 0.00070
NM_003235.5(TG):c.455G>A (p.Arg152His) rs114781869 0.00059
NM_003235.5(TG):c.4481C>T (p.Pro1494Leu) rs146498231 0.00053
NM_003235.5(TG):c.3139+9G>A rs201582196 0.00046
NM_003235.5(TG):c.1573G>A (p.Gly525Arg) rs140232663 0.00043
NM_003235.5(TG):c.8026C>T (p.Arg2676Trp) rs114613744 0.00038
NM_003235.5(TG):c.4527C>T (p.His1509=) rs201216611 0.00037
NM_003235.5(TG):c.7753C>T (p.Arg2585Trp) rs114211101 0.00032
NM_003235.5(TG):c.1900G>A (p.Gly634Arg) rs116417639 0.00028
NM_003235.5(TG):c.60T>C (p.Asn20=) rs140030312 0.00024
NM_003235.5(TG):c.1020C>T (p.Asp340=) rs138114586 0.00020
NM_003235.5(TG):c.3848-8G>T rs192497923 0.00018
NM_003235.5(TG):c.4638C>T (p.Gly1546=) rs116663504 0.00018
NM_003235.5(TG):c.4604A>G (p.Asp1535Gly) rs762221625 0.00006
NM_003235.5(TG):c.2762-4C>T rs372101475 0.00004
NM_003235.5(TG):c.475C>T (p.Arg159Ter) rs759267330 0.00004
NM_003235.5(TG):c.6529C>T (p.Arg2177Cys) rs555719562 0.00004
NM_003235.5(TG):c.6565A>G (p.Ile2189Val) rs140792871 0.00004
NM_003235.5(TG):c.6695C>T (p.Pro2232Leu) rs201514086 0.00004
NM_003235.5(TG):c.6933T>C (p.Ser2311=) rs568446863 0.00004
NM_003235.5(TG):c.2311C>T (p.Gln771Ter) rs778743706 0.00003
NM_003235.5(TG):c.3847+1G>C rs748654543 0.00003
NM_003235.5(TG):c.5672dup (p.Trp1892fs) rs1470919968 0.00003
NM_003235.5(TG):c.6701C>A (p.Ala2234Asp) rs370991693 0.00003
NM_003235.5(TG):c.7123G>A (p.Gly2375Arg) rs137854434 0.00003
NM_003235.5(TG):c.5992C>T (p.Arg1998Ter) rs777075341 0.00001
NM_003235.5(TG):c.638+5G>A rs774274702 0.00001
NM_003235.5(TG):c.6517C>T (p.Arg2173Ter) rs762595592 0.00001
NM_003235.5(TG):c.6549del (p.Tyr2184fs) rs778316724 0.00001
NM_003235.5(TG):c.6725G>A (p.Arg2242His) rs2069566 0.00001
NM_003235.5(TG):c.85C>T (p.Gln29Ter) rs1554648860 0.00001
NM_003235.5(TG):c.115G>T (p.Glu39Ter)
NM_003235.5(TG):c.2443G>T (p.Gly815Ter) rs16904774
NM_003235.5(TG):c.2761+11G>T rs77660463
NM_003235.5(TG):c.2762-4del rs758239399
NM_003235.5(TG):c.2963G>A (p.Arg988His) rs16893332
NM_003235.5(TG):c.2963G>C (p.Arg988Pro) rs16893332
NM_003235.5(TG):c.3217+5G>A rs2132264436
NM_003235.5(TG):c.3231C>A (p.Cys1077Ter) rs142308887
NM_003235.5(TG):c.3749G>T (p.Arg1250Leu) rs114944116
NM_003235.5(TG):c.3871C>T (p.Gln1291Ter)
NM_003235.5(TG):c.4528+1G>A rs2490314665
NM_003235.5(TG):c.478+15G>A rs141561325
NM_003235.5(TG):c.5184C>A (p.Cys1728Ter) rs199599591
NM_003235.5(TG):c.5509_5518del (p.Lys1837fs) rs1554681801
NM_003235.5(TG):c.7588C>T (p.Arg2530Ter)
NM_003235.5(TG):c.7847A>T (p.Asn2616Ile) rs10091530
NM_003235.5(TG):c.8189-14C>A rs374177941

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