ClinVar Miner

Variants in gene MLH3 with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic) 		Variants with a confidence conflict
(e.g. benign vs likely benign) 		Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects) 		Variants with a clinically significant conflict
(e.g. benign vs pathogenic) 		Variants with any conflict
3051 199 0 38 54 0 16 98

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 0 14 0 0
likely pathogenic 0 0 3 0 0
uncertain significance 14 3 0 45 16
likely benign 0 0 45 0 38
benign 0 0 16 38 0

All variants with conflicting interpretations #

Total variants: 98
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_001040108.2(MLH3):c.*3148A>G rs108621 0.42508
NM_001040108.2(MLH3):c.2159A>G (p.Tyr720Cys) rs28756988 0.02978
NM_001040108.2(MLH3):c.666G>A (p.Lys222=) rs28756980 0.01977
NM_001040108.1(MLH3):c.-204G>A rs116839793 0.01976
NM_001040108.2(MLH3):c.444G>C (p.Val148=) rs11556091 0.01944
NM_001040108.2(MLH3):c.4242+13C>G rs77157930 0.01890
NM_001040108.2(MLH3):c.2533A>G (p.Ser845Gly) rs28756992 0.01483
NM_001040108.2(MLH3):c.691A>C (p.Lys231Gln) rs28756981 0.01278
NM_001040108.2(MLH3):c.1258G>A (p.Val420Ile) rs28756982 0.01142
NM_001040108.2(MLH3):c.2825C>T (p.Thr942Ile) rs17102999 0.01049
NM_001040108.2(MLH3):c.2896T>C (p.Ser966Pro) rs17782839 0.01041
NM_001040108.2(MLH3):c.3570+28A>T rs67547819 0.00949
NM_001040108.2(MLH3):c.8A>G (p.Lys3Arg) rs114829239 0.00849
NM_001040108.2(MLH3):c.1870G>C (p.Glu624Gln) rs28756986 0.00750
NM_001040108.2(MLH3):c.408T>C (p.Asp136=) rs61755655 0.00552
NM_001040108.2(MLH3):c.3217G>A (p.Asp1073Asn) rs28756993 0.00551
NM_001040108.2(MLH3):c.3987+15C>T rs117251698 0.00472
NM_001040108.2(MLH3):c.3315C>A (p.Asp1105Glu) rs28757008 0.00323
NM_001040108.2(MLH3):c.3987+7C>A rs28757028 0.00219
NM_001040108.2(MLH3):c.3644-13C>T rs189760727 0.00199
NM_001040108.2(MLH3):c.2425A>G (p.Met809Val) rs61752722 0.00197
NM_001040108.2(MLH3):c.2490T>G (p.Phe830Leu) rs114015611 0.00177
NM_001040108.2(MLH3):c.1939C>T (p.Arg647Cys) rs28756987 0.00171
NM_001040108.2(MLH3):c.-4T>G rs28756977 0.00168
NM_001040108.2(MLH3):c.1799G>A (p.Arg600Gln) rs28756984 0.00168
NM_001040108.2(MLH3):c.735C>T (p.Tyr245=) rs111782152 0.00162
NM_001040108.2(MLH3):c.2924A>G (p.Asn975Ser) rs141066164 0.00160
NM_001040108.2(MLH3):c.429G>A (p.Gly143=) rs138943686 0.00160
NM_001040108.2(MLH3):c.2167G>A (p.Val723Ile) rs28756989 0.00153
NM_001040108.2(MLH3):c.3488G>A (p.Gly1163Asp) rs28757011 0.00119
NM_001040108.2(MLH3):c.359T>C (p.Phe120Ser) rs28756979 0.00113
NM_001040108.2(MLH3):c.3746C>T (p.Ser1249Phe) rs139265757 0.00103
NM_001040108.2(MLH3):c.4351G>A (p.Glu1451Lys) rs28939071 0.00103
NM_001040108.2(MLH3):c.394G>A (p.Ala132Thr) rs148095325 0.00097
NM_001040108.2(MLH3):c.423C>T (p.Ser141=) rs142179277 0.00092
NM_001040108.2(MLH3):c.2670G>A (p.Met890Ile) rs147021156 0.00089
NM_001040108.2(MLH3):c.2838C>A (p.Ser946=) rs181990057 0.00073
NM_001040108.2(MLH3):c.1234A>G (p.Lys412Glu) rs61754769 0.00061
NM_001040108.2(MLH3):c.-3A>G rs146166860 0.00059
NM_001040108.2(MLH3):c.1637G>T (p.Arg546Ile) rs55725216 0.00048
NM_001040108.2(MLH3):c.2911G>A (p.Val971Ile) rs41555714 0.00048
NM_001040108.2(MLH3):c.902A>T (p.Glu301Val) rs77687901 0.00040
NM_001040108.2(MLH3):c.837C>T (p.Cys279=) rs149962294 0.00039
NM_001040108.2(MLH3):c.3344G>A (p.Arg1115Gln) rs78311619 0.00038
NM_001040108.2(MLH3):c.3440A>T (p.Asn1147Ile) rs142124529 0.00035
NM_001040108.2(MLH3):c.4011+15T>G rs139032600 0.00033
NM_001040108.2(MLH3):c.2180G>A (p.Ser727Asn) rs116526686 0.00029
NM_001040108.2(MLH3):c.1168T>A (p.Phe390Ile) rs61752721 0.00028
NM_001040108.2(MLH3):c.3280+14A>T rs142042839 0.00019
NM_001040108.2(MLH3):c.3563C>G (p.Ser1188Ter) rs193219754 0.00019
NM_001040108.2(MLH3):c.3137G>A (p.Arg1046Gln) rs201303087 0.00018
NM_001040108.2(MLH3):c.713A>C (p.Tyr238Ser) rs144707485 0.00016
NM_001040108.2(MLH3):c.3636C>T (p.Gly1212=) rs571755678 0.00010
NM_001040108.2(MLH3):c.2356G>A (p.Val786Ile) rs372089146 0.00008
NM_001040108.2(MLH3):c.2435G>C (p.Ser812Thr) rs763408801 0.00008
NM_001040108.2(MLH3):c.3576C>T (p.Leu1192=) rs376981545 0.00007
NM_001040108.2(MLH3):c.1651C>T (p.Pro551Ser) rs902755970 0.00006
NM_001040108.2(MLH3):c.2224C>T (p.Arg742Cys) rs774817891 0.00006
NM_001040108.2(MLH3):c.3312C>T (p.Ser1104=) rs149369905 0.00006
NM_001040108.2(MLH3):c.3716-4A>G rs777308221 0.00006
NM_001040108.2(MLH3):c.277C>G (p.Arg93Gly) rs28756978 0.00005
NM_001040108.2(MLH3):c.2373G>A (p.Leu791=) rs764724825 0.00004
NM_001040108.2(MLH3):c.3723C>T (p.Tyr1241=) rs145627040 0.00004
NM_001040108.2(MLH3):c.4032C>T (p.Gly1344=) rs565238806 0.00004
NM_001040108.2(MLH3):c.598C>T (p.Gln200Ter) rs1039843487 0.00004
NM_001040108.2(MLH3):c.911G>T (p.Gly304Val) rs540533901 0.00004
NM_001040108.2(MLH3):c.2941G>A (p.Gly981Ser) rs377337763 0.00003
NM_001040108.2(MLH3):c.1142G>A (p.Arg381His) rs751375245 0.00002
NM_001040108.2(MLH3):c.1798C>T (p.Arg600Ter) rs927878214 0.00002
NM_001040108.2(MLH3):c.3020A>G (p.Asn1007Ser) rs776639203 0.00002
NM_001040108.2(MLH3):c.3405C>T (p.Ser1135=) rs746155226 0.00002
NM_001040108.2(MLH3):c.4289G>A (p.Arg1430His) rs760305520 0.00002
NM_001040108.2(MLH3):c.1021del (p.Gln341fs) rs879779919 0.00001
NM_001040108.2(MLH3):c.1125T>C (p.Asp375=) rs781394261 0.00001
NM_001040108.2(MLH3):c.1306A>G (p.Asn436Asp) rs754824568 0.00001
NM_001040108.2(MLH3):c.1490T>C (p.Leu497Ser) rs1009026527 0.00001
NM_001040108.2(MLH3):c.3384T>C (p.Thr1128=) rs370951929 0.00001
NM_001040108.2(MLH3):c.3784C>T (p.Pro1262Ser) rs372912259 0.00001
NM_001040108.2(MLH3):c.3826T>C (p.Trp1276Arg) rs121908439 0.00001
NM_001040108.2(MLH3):c.3997C>T (p.Arg1333Ter) rs1255282773 0.00001
NM_001040108.2(MLH3):c.4239A>G (p.Lys1413=) rs975447813 0.00001
NM_001040108.2(MLH3):c.1301dup (p.Asn434fs) rs1212794587
NM_001040108.2(MLH3):c.149T>A (p.Phe50Tyr) rs148409389
NM_001040108.2(MLH3):c.1755dup (p.Glu586fs) rs751465048
NM_001040108.2(MLH3):c.1774A>G (p.Arg592Gly) rs2503287051
NM_001040108.2(MLH3):c.2021dup (p.Asn674fs) rs767782578
NM_001040108.2(MLH3):c.2221G>A (p.Val741Ile) rs28756990
NM_001040108.2(MLH3):c.2482G>T (p.Glu828Ter) rs587776622
NM_001040108.2(MLH3):c.2937del (p.Thr980fs) rs758226404
NM_001040108.2(MLH3):c.3132G>A (p.Trp1044Ter) rs772314175
NM_001040108.2(MLH3):c.3154del (p.Leu1052fs) rs745657036
NM_001040108.2(MLH3):c.3465+14A>G rs775972214
NM_001040108.2(MLH3):c.3570+29AT[10] rs145063005
NM_001040108.2(MLH3):c.3713T>C (p.Ile1238Thr) rs1363518429
NM_001040108.2(MLH3):c.3716-1G>A rs1243847782
NM_001040108.2(MLH3):c.3786G>T (p.Pro1262=) rs28757027
NM_001040108.2(MLH3):c.615del (p.Asp206fs) rs746171271
NM_001040108.2(MLH3):c.885del (p.His296fs) rs1431264077

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