ClinVar Miner

Variants in gene LRP2 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic) 		Variants with a confidence conflict
(e.g. benign vs likely benign) 		Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects) 		Variants with a clinically significant conflict
(e.g. benign vs pathogenic) 		Variants with any conflict
4437 433 0 134 105 0 5 220

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 10 2 0 0
likely pathogenic 10 0 4 0 0
uncertain significance 2 4 0 103 18
likely benign 0 0 103 0 124
benign 0 0 18 124 0

All variants with conflicting interpretations #

Total variants: 220
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_004525.3(LRP2):c.63G>C (p.Ala21=) rs1559014 0.99771
NM_004525.3(LRP2):c.79+15A>G rs1559013 0.98948
NM_004525.3(LRP2):c.12280A>G (p.Lys4094Glu) rs2075252 0.79497
NM_004525.3(LRP2):c.12628A>C (p.Ile4210Leu) rs4667591 0.61608
NM_004525.3(LRP2):c.2025C>T (p.Val675=) rs830994 0.61350
NM_004525.3(LRP2):c.13113C>T (p.Ile4371=) rs990626 0.59977
NM_004525.3(LRP2):c.2460A>G (p.Thr820=) rs2241190 0.54926
NM_004525.3(LRP2):c.3069A>G (p.Thr1023=) rs831043 0.53755
NM_004525.3(LRP2):c.3660A>G (p.Ala1220=) rs831042 0.50520
NM_004525.3(LRP2):c.10503G>A (p.Gln3501=) rs2229265 0.45057
NM_004525.3(LRP2):c.3054C>A (p.Thr1018=) rs2075249 0.42392
NM_004525.3(LRP2):c.4875T>C (p.Cys1625=) rs2229267 0.38438
NM_004525.3(LRP2):c.248A>G (p.Asn83Ser) rs2229263 0.32675
NM_004525.3(LRP2):c.639C>T (p.Asp213=) rs2229266 0.30270
NM_004525.3(LRP2):c.8614G>A (p.Ala2872Thr) rs2228171 0.25207
NM_004525.3(LRP2):c.5100C>T (p.Ser1700=) rs2302694 0.19156
NM_004525.3(LRP2):c.5859A>G (p.Arg1953=) rs11886219 0.15625
NM_004525.3(LRP2):c.11601T>C (p.Cys3867=) rs2229268 0.15380
NM_004525.3(LRP2):c.7626C>G (p.Arg2542=) rs13397109 0.12249
NM_004525.3(LRP2):c.2376T>C (p.Asp792=) rs33954745 0.08944
NM_004525.3(LRP2):c.428-8T>A rs761869255 0.05647
NM_004525.3(LRP2):c.6759T>C (p.Asp2253=) rs35114151 0.04805
NM_004525.3(LRP2):c.4236G>C (p.Arg1412=) rs34915742 0.04398
NM_004525.3(LRP2):c.4046-6T>C rs76714416 0.04151
NM_004525.3(LRP2):c.13155C>T (p.His4385=) rs16856476 0.04079
NM_004525.3(LRP2):c.3836A>C (p.Asp1279Ala) rs17848149 0.03848
NM_004525.3(LRP2):c.7894A>G (p.Asn2632Asp) rs17848169 0.02788
NM_004525.3(LRP2):c.428-9T>A rs1162568534 0.02580
NM_004525.3(LRP2):c.12151+4T>C rs17848192 0.02503
NM_004525.3(LRP2):c.2006G>A (p.Gly669Asp) rs34291900 0.02482
NM_004525.3(LRP2):c.6045C>T (p.Ala2015=) rs34834388 0.01962
NM_004525.3(LRP2):c.4344C>G (p.Ala1448=) rs35297090 0.01784
NM_004525.3(LRP2):c.11759-5T>G rs76488092 0.01424
NM_004525.3(LRP2):c.7253A>G (p.Glu2418Gly) rs61995915 0.01278
NM_004525.3(LRP2):c.3452C>T (p.Pro1151Leu) rs150552608 0.01270
NM_004525.3(LRP2):c.13250G>A (p.Gly4417Asp) rs41268685 0.01191
NM_004525.3(LRP2):c.13134C>G (p.Pro4378=) rs73970129 0.01063
NM_004525.3(LRP2):c.10804G>A (p.Ala3602Thr) rs144081819 0.01045
NM_004525.3(LRP2):c.5293G>A (p.Val1765Met) rs116456291 0.01031
NM_004525.3(LRP2):c.9033-8T>C rs140148483 0.01021
NM_004525.3(LRP2):c.5085G>A (p.Ser1695=) rs145384264 0.00999
NM_004525.3(LRP2):c.1172-8G>A rs115371758 0.00955
NM_004525.3(LRP2):c.1167T>G (p.Asp389Glu) rs111704488 0.00892
NM_004525.3(LRP2):c.11346C>T (p.Asn3782=) rs7598640 0.00882
NM_004525.3(LRP2):c.11996T>G (p.Val3999Gly) rs79723119 0.00834
NM_004525.3(LRP2):c.2175C>T (p.Thr725=) rs141180155 0.00820
NM_004525.3(LRP2):c.13803G>A (p.Met4601Ile) rs34564141 0.00790
NM_004525.3(LRP2):c.10403C>T (p.Pro3468Leu) rs143367996 0.00689
NM_004525.3(LRP2):c.923-6G>A rs144147038 0.00611
NM_004525.3(LRP2):c.11092G>A (p.Val3698Met) rs34355135 0.00561
NM_004525.3(LRP2):c.8892G>A (p.Arg2964=) rs149148763 0.00557
NM_004525.3(LRP2):c.3659C>T (p.Ala1220Val) rs144723964 0.00467
NM_004525.3(LRP2):c.9613A>G (p.Asn3205Asp) rs35734447 0.00421
NM_004525.3(LRP2):c.7917A>C (p.Gly2639=) rs144126440 0.00414
NM_004525.3(LRP2):c.13620+14C>G rs142018904 0.00384
NM_004525.3(LRP2):c.149C>G (p.Thr50Ser) rs114460450 0.00342
NM_004525.3(LRP2):c.6967C>T (p.Leu2323=) rs149367019 0.00326
NM_004525.3(LRP2):c.2933C>T (p.Thr978Met) rs114842875 0.00322
NM_004525.3(LRP2):c.403G>A (p.Asp135Asn) rs142594441 0.00316
NM_004525.3(LRP2):c.2456G>A (p.Arg819His) rs142080405 0.00306
NM_004525.3(LRP2):c.5538+10C>T rs115659204 0.00296
NM_004525.3(LRP2):c.1869C>T (p.Ala623=) rs148468966 0.00288
NM_004525.3(LRP2):c.10937G>A (p.Arg3646His) rs142549310 0.00281
NM_004525.3(LRP2):c.92C>T (p.Ala31Val) rs144829356 0.00280
NM_004525.3(LRP2):c.4924A>G (p.Ile1642Val) rs144737909 0.00275
NM_004525.3(LRP2):c.9282C>T (p.Cys3094=) rs34813328 0.00261
NM_004525.3(LRP2):c.2520A>G (p.Leu840=) rs114780253 0.00255
NM_004525.3(LRP2):c.1973A>G (p.Tyr658Cys) rs111360923 0.00248
NM_004525.3(LRP2):c.-5C>T rs373286009 0.00241
NM_004525.3(LRP2):c.5390A>G (p.Asn1797Ser) rs138070797 0.00233
NM_004525.3(LRP2):c.11663G>A (p.Arg3888His) rs77686710 0.00218
NM_004525.3(LRP2):c.12379C>A (p.Arg4127Ser) rs148356370 0.00217
NM_004525.3(LRP2):c.1346T>A (p.Phe449Tyr) rs139167787 0.00211
NM_004525.3(LRP2):c.2079C>T (p.Phe693=) rs145709922 0.00210
NM_004525.3(LRP2):c.769+9G>A rs148452352 0.00208
NM_004525.3(LRP2):c.12380G>A (p.Arg4127His) rs142934522 0.00196
NM_004525.3(LRP2):c.6850A>G (p.Thr2284Ala) rs35413340 0.00196
NM_004525.3(LRP2):c.13685T>C (p.Val4562Ala) rs142245618 0.00192
NM_004525.3(LRP2):c.2513+14T>C rs201785482 0.00192
NM_004525.3(LRP2):c.10170-15T>G rs144579935 0.00190
NM_004525.3(LRP2):c.10030G>A (p.Ala3344Thr) rs137983840 0.00185
NM_004525.3(LRP2):c.10233C>T (p.Phe3411=) rs139363553 0.00183
NM_004525.3(LRP2):c.3122A>G (p.Asn1041Ser) rs143028579 0.00170
NM_004525.3(LRP2):c.4351G>T (p.Val1451Phe) rs146289506 0.00164
NM_004525.3(LRP2):c.9914G>A (p.Arg3305His) rs3213760 0.00161
NM_004525.3(LRP2):c.6473A>C (p.Asn2158Thr) rs34052957 0.00157
NM_004525.3(LRP2):c.12725A>G (p.Asp4242Gly) rs35942532 0.00156
NM_004525.3(LRP2):c.9477G>A (p.Met3159Ile) rs144322413 0.00152
NM_004525.3(LRP2):c.6954C>T (p.Asp2318=) rs34223099 0.00148
NM_004525.3(LRP2):c.9147C>T (p.Phe3049=) rs146115458 0.00146
NM_004525.3(LRP2):c.13935C>T (p.Thr4645=) rs150373759 0.00144
NM_004525.3(LRP2):c.7406A>G (p.Asp2469Gly) rs116507519 0.00143
NM_004525.3(LRP2):c.2178G>T (p.Leu726Phe) rs144451000 0.00139
NM_004525.3(LRP2):c.2908+18G>A rs182125868 0.00136
NM_004525.3(LRP2):c.13902C>G (p.Thr4634=) rs112043518 0.00132
NM_004525.3(LRP2):c.5209C>T (p.Leu1737Phe) rs149469954 0.00126
NM_004525.3(LRP2):c.6267G>A (p.Pro2089=) rs2228169 0.00126
NM_004525.3(LRP2):c.13921A>T (p.Thr4641Ser) rs79179577 0.00123
NM_004525.3(LRP2):c.3110G>A (p.Arg1037Lys) rs147058423 0.00123
NM_004525.3(LRP2):c.3100A>G (p.Lys1034Glu) rs150395163 0.00120
NM_004525.3(LRP2):c.391A>G (p.Arg131Gly) rs34592807 0.00119
NM_004525.3(LRP2):c.170C>T (p.Ala57Val) rs115350461 0.00111
NM_004525.3(LRP2):c.2603C>G (p.Thr868Ser) rs150752263 0.00100
NM_004525.3(LRP2):c.4831C>T (p.Leu1611=) rs151079411 0.00091
NM_004525.3(LRP2):c.6858T>A (p.Phe2286Leu) rs140918583 0.00089
NM_004525.3(LRP2):c.6176C>T (p.Ser2059Phe) rs148299415 0.00088
NM_004525.3(LRP2):c.10165A>G (p.Ile3389Val) rs140272085 0.00087
NM_004525.3(LRP2):c.9311G>A (p.Ser3104Asn) rs139523655 0.00084
NM_004525.3(LRP2):c.987G>A (p.Ala329=) rs141751667 0.00084
NM_004525.3(LRP2):c.9650A>G (p.Tyr3217Cys) rs143150497 0.00083
NM_004525.3(LRP2):c.6160G>A (p.Asp2054Asn) rs138269726 0.00078
NM_004525.3(LRP2):c.299G>A (p.Arg100His) rs35642533 0.00075
NM_004525.3(LRP2):c.3311A>G (p.His1104Arg) rs144906000 0.00073
NM_004525.3(LRP2):c.1176C>T (p.Gly392=) rs369145798 0.00070
NM_004525.3(LRP2):c.6938C>T (p.Pro2313Leu) rs73035708 0.00069
NM_004525.3(LRP2):c.6256A>T (p.Thr2086Ser) rs146149181 0.00067
NM_004525.3(LRP2):c.4803C>T (p.Cys1601=) rs141068435 0.00065
NM_004525.3(LRP2):c.7747G>A (p.Val2583Met) rs145201961 0.00063
NM_004525.3(LRP2):c.11264-14C>G rs377424162 0.00062
NM_004525.3(LRP2):c.891T>C (p.Asp297=) rs112343092 0.00062
NM_004525.3(LRP2):c.9234C>T (p.His3078=) rs116975392 0.00059
NM_004525.3(LRP2):c.3364A>G (p.Ile1122Val) rs149853330 0.00056
NM_004525.3(LRP2):c.1189A>G (p.Ile397Val) rs140575982 0.00049
NM_004525.3(LRP2):c.13610A>C (p.Gln4537Pro) rs188918037 0.00049
NM_004525.3(LRP2):c.7007G>A (p.Arg2336Gln) rs147287428 0.00049
NM_004525.3(LRP2):c.7866C>T (p.Asp2622=) rs139514301 0.00045
NM_004525.3(LRP2):c.8901C>G (p.Pro2967=) rs145179638 0.00045
NM_004525.3(LRP2):c.2320+9G>A rs368933798 0.00044
NM_004525.3(LRP2):c.3128A>G (p.Tyr1043Cys) rs201299366 0.00043
NM_004525.3(LRP2):c.6553C>T (p.Leu2185Phe) rs143884041 0.00043
NM_004525.3(LRP2):c.12421G>A (p.Val4141Ile) rs150382715 0.00041
NM_004525.3(LRP2):c.6048C>T (p.Ala2016=) rs144449508 0.00040
NM_004525.3(LRP2):c.9363C>T (p.Gly3121=) rs146783211 0.00038
NM_004525.3(LRP2):c.11288A>T (p.Glu3763Val) rs200475391 0.00036
NM_004525.3(LRP2):c.11322G>A (p.Ser3774=) rs141727314 0.00034
NM_004525.3(LRP2):c.2511C>T (p.Ala837=) rs375313914 0.00034
NM_004525.3(LRP2):c.8177G>C (p.Gly2726Ala) rs144594832 0.00034
NM_004525.3(LRP2):c.3551-9C>A rs373882047 0.00032
NM_004525.3(LRP2):c.1731G>A (p.Arg577=) rs142698246 0.00031
NM_004525.3(LRP2):c.10880G>T (p.Ser3627Ile) rs138660534 0.00027
NM_004525.3(LRP2):c.8505T>C (p.Cys2835=) rs140925226 0.00027
NM_004525.3(LRP2):c.5107C>T (p.Pro1703Ser) rs141260047 0.00024
NM_004525.3(LRP2):c.2321-3T>C rs529050791 0.00023
NM_004525.3(LRP2):c.12958A>G (p.Ile4320Val) rs141452561 0.00021
NM_004525.3(LRP2):c.230A>T (p.Glu77Val) rs200113428 0.00021
NM_004525.3(LRP2):c.39C>T (p.Leu13=) rs529649802 0.00021
NM_004525.3(LRP2):c.6130G>A (p.Ala2044Thr) rs142266106 0.00020
NM_004525.3(LRP2):c.11478G>A (p.Ala3826=) rs150464677 0.00019
NM_004525.3(LRP2):c.13359C>T (p.Ser4453=) rs202161925 0.00019
NM_004525.3(LRP2):c.8073C>T (p.His2691=) rs146772976 0.00018
NM_004525.3(LRP2):c.2210C>T (p.Ser737Leu) rs201860953 0.00017
NM_004525.3(LRP2):c.8514C>T (p.Arg2838=) rs145154135 0.00017
NM_004525.3(LRP2):c.10661G>A (p.Arg3554Gln) rs139257219 0.00016
NM_004525.3(LRP2):c.12687T>C (p.Gly4229=) rs140195786 0.00016
NM_004525.3(LRP2):c.5155G>C (p.Gly1719Arg) rs144054579 0.00016
NM_004525.3(LRP2):c.8132G>A (p.Arg2711His) rs190037522 0.00015
NM_004525.3(LRP2):c.12296-7T>A rs200755164 0.00013
NM_004525.3(LRP2):c.5553C>T (p.His1851=) rs369998522 0.00013
NM_004525.3(LRP2):c.12756C>T (p.Asp4252=) rs201793817 0.00012
NM_004525.3(LRP2):c.10536C>T (p.Cys3512=) rs531013104 0.00011
NM_004525.3(LRP2):c.5370A>G (p.Gln1790=) rs201155152 0.00011
NM_004525.3(LRP2):c.8169C>T (p.Asn2723=) rs200369596 0.00011
NM_004525.3(LRP2):c.8112C>A (p.Ser2704=) rs148473513 0.00010
NM_004525.3(LRP2):c.9066C>T (p.Ser3022=) rs374380173 0.00010
NM_004525.3(LRP2):c.10906C>T (p.Arg3636Trp) rs747833963 0.00009
NM_004525.3(LRP2):c.12296-4G>A rs375166826 0.00009
NM_004525.3(LRP2):c.6106G>A (p.Val2036Ile) rs34041086 0.00009
NM_004525.3(LRP2):c.7284T>G (p.Ser2428Arg) rs373362950 0.00009
NM_004525.3(LRP2):c.7586A>G (p.His2529Arg) rs139696516 0.00009
NM_004525.3(LRP2):c.11335G>A (p.Asp3779Asn) rs199583537 0.00008
NM_004525.3(LRP2):c.5120C>T (p.Ser1707Phe) rs745788682 0.00008
NM_004525.3(LRP2):c.11244C>T (p.Asn3748=) rs542010522 0.00007
NM_004525.3(LRP2):c.1425C>T (p.Asp475=) rs186484839 0.00007
NM_004525.3(LRP2):c.3285C>T (p.Gly1095=) rs986671553 0.00007
NM_004525.3(LRP2):c.8882C>T (p.Pro2961Leu) rs780122177 0.00007
NM_004525.3(LRP2):c.1330G>A (p.Val444Met) rs148503556 0.00006
NM_004525.3(LRP2):c.630C>T (p.Asp210=) rs368336310 0.00006
NM_004525.3(LRP2):c.8300G>A (p.Gly2767Asp) rs138382534 0.00006
NM_004525.3(LRP2):c.10704G>A (p.Pro3568=) rs756473581 0.00005
NM_004525.3(LRP2):c.2813G>A (p.Arg938Gln) rs372927481 0.00005
NM_004525.3(LRP2):c.3495G>A (p.Ser1165=) rs186494101 0.00005
NM_004525.3(LRP2):c.5367G>A (p.Glu1789=) rs528249827 0.00005
NM_004525.3(LRP2):c.770-12T>C rs138572086 0.00005
NM_004525.3(LRP2):c.8228C>T (p.Pro2743Leu) rs545645633 0.00005
NM_004525.3(LRP2):c.8624G>A (p.Arg2875His) rs369195059 0.00005
NM_004525.3(LRP2):c.13002C>T (p.Cys4334=) rs774133574 0.00003
NM_004525.3(LRP2):c.13138C>G (p.Pro4380Ala) rs765875054 0.00003
NM_004525.3(LRP2):c.13753C>T (p.Arg4585Ter) rs202057289 0.00003
NM_004525.3(LRP2):c.9128G>A (p.Arg3043His) rs143078432 0.00003
NM_004525.3(LRP2):c.6470-4A>G rs373350854 0.00002
NM_004525.3(LRP2):c.10660C>T (p.Arg3554Ter) rs768458485 0.00001
NM_004525.3(LRP2):c.1773-3C>T rs752242118 0.00001
NM_004525.3(LRP2):c.2599A>G (p.Thr867Ala) rs143822500 0.00001
NM_004525.3(LRP2):c.2639+1G>A rs746752313 0.00001
NM_004525.3(LRP2):c.317G>A (p.Ser106Asn) rs759417883 0.00001
NM_004525.3(LRP2):c.3573A>G (p.Gln1191=) rs750430784 0.00001
NM_004525.3(LRP2):c.3667+1G>A rs752197557 0.00001
NM_004525.3(LRP2):c.5867T>G (p.Leu1956Arg) rs756470766 0.00001
NM_004525.3(LRP2):c.6283C>T (p.Arg2095Ter) rs753549113 0.00001
NM_004525.3(LRP2):c.863G>A (p.Gly288Glu) rs147110349 0.00001
NM_004525.3(LRP2):c.9342C>T (p.Cys3114=) rs199803029 0.00001
NM_004525.3(LRP2):c.9706C>T (p.Arg3236Ter) rs1310470715 0.00001
NM_004525.3(LRP2):c.9993A>G (p.Gln3331=) rs1188846190 0.00001
NM_004525.3(LRP2):c.11568G>A (p.Pro3856=) rs745949029
NM_004525.3(LRP2):c.12125G>A (p.Arg4042His) rs199874294
NM_004525.3(LRP2):c.13139del (p.Pro4380fs) rs80338754
NM_004525.3(LRP2):c.13139dup (p.Cys4381fs) rs80338754
NM_004525.3(LRP2):c.13519-40CT[9] rs138614485
NM_004525.3(LRP2):c.13680G>T (p.Glu4560Asp) rs192849943
NM_004525.3(LRP2):c.169G>T (p.Ala57Ser) rs147295930
NM_004525.3(LRP2):c.3932G>A (p.Arg1311His) rs140748929
NM_004525.3(LRP2):c.402C>A (p.Pro134=) rs34104660
NM_004525.3(LRP2):c.428-10_428-8del rs370823033
NM_004525.3(LRP2):c.428-11_428-8del rs370823033
NM_004525.3(LRP2):c.428-9_428-8del rs370823033
NM_004525.3(LRP2):c.5648+7A>C rs775694684
NM_004525.3(LRP2):c.7564T>C (p.Tyr2522His) rs80338747
NM_004525.3(LRP2):c.775G>C (p.Gly259Arg) rs34693334
NM_004525.3(LRP2):c.832C>T (p.Arg278Ter) rs1358532875
NM_004525.3(LRP2):c.8699-8C>T rs145301652

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