ClinVar Miner

Variants in gene GRIN2B with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
1646 93 0 64 25 0 7 89

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 20 2 0 0
likely pathogenic 20 0 6 0 0
uncertain significance 2 6 0 21 10
likely benign 0 0 21 0 44
benign 0 0 10 44 0

All variants with conflicting interpretations #

Total variants: 89
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_000834.5(GRIN2B):c.366C>G (p.Pro122=) rs7301328 0.41972
NM_000834.5(GRIN2B):c.3534C>T (p.His1178=) rs1806191 0.39095
NM_000834.5(GRIN2B):c.1665C>T (p.Ser555=) rs1805482 0.26553
NM_000834.5(GRIN2B):c.2664C>T (p.Thr888=) rs1806201 0.24515
NM_000834.5(GRIN2B):c.4197T>C (p.His1399=) rs1805247 0.16667
NM_000834.5(GRIN2B):c.2514C>T (p.Cys838=) rs3026160 0.08178
NM_000834.5(GRIN2B):c.15G>A (p.Ala5=) rs34315573 0.03193
NM_000834.5(GRIN2B):c.870C>T (p.Pro290=) rs1124894 0.02647
NM_000834.5(GRIN2B):c.504C>A (p.Ile168=) rs36031537 0.01733
NM_000834.5(GRIN2B):c.2691C>T (p.Asn897=) rs35125534 0.01050
NM_000834.5(GRIN2B):c.3498C>T (p.Ser1166=) rs45600931 0.00523
NM_000834.5(GRIN2B):c.3552C>T (p.Gly1184=) rs141886903 0.00206
NM_000834.5(GRIN2B):c.3117C>T (p.Tyr1039=) rs147762014 0.00118
NM_000834.5(GRIN2B):c.4240G>T (p.Ala1414Ser) rs140744818 0.00078
NM_000834.5(GRIN2B):c.1569C>T (p.Val523=) rs148573953 0.00073
NM_000834.5(GRIN2B):c.228C>T (p.Thr76=) rs77299791 0.00070
NM_000834.5(GRIN2B):c.1780+8C>T rs199986080 0.00064
NM_000834.5(GRIN2B):c.3747C>T (p.Gly1249=) rs138771137 0.00063
NM_000834.5(GRIN2B):c.4101C>T (p.Pro1367=) rs112932810 0.00046
NM_000834.5(GRIN2B):c.1851C>T (p.Ser617=) rs147373250 0.00045
NM_000834.5(GRIN2B):c.812C>T (p.Ala271Val) rs138098032 0.00041
NM_000834.5(GRIN2B):c.3389G>A (p.Arg1130Gln) rs148625092 0.00038
NM_000834.5(GRIN2B):c.3807A>T (p.Pro1269=) rs78765966 0.00035
NM_000834.5(GRIN2B):c.2628G>A (p.Ala876=) rs199710029 0.00033
NM_000834.5(GRIN2B):c.4113C>T (p.Tyr1371=) rs146792012 0.00030
NM_000834.5(GRIN2B):c.2931C>G (p.Asp977Glu) rs147956755 0.00029
NM_000834.5(GRIN2B):c.3799G>T (p.Ala1267Ser) rs141844705 0.00029
NM_000834.5(GRIN2B):c.2703G>A (p.Leu901=) rs145005918 0.00026
NM_000834.5(GRIN2B):c.1356C>T (p.Tyr452=) rs142935139 0.00023
NM_000834.5(GRIN2B):c.3549G>A (p.Thr1183=) rs201568782 0.00021
NM_000834.5(GRIN2B):c.2481G>A (p.Ala827=) rs189384622 0.00015
NM_000834.5(GRIN2B):c.291G>A (p.Val97=) rs202223470 0.00013
NM_000834.5(GRIN2B):c.3076G>A (p.Gly1026Ser) rs201963596 0.00011
NM_000834.5(GRIN2B):c.3837T>G (p.Thr1279=) rs1806200 0.00009
NM_000834.5(GRIN2B):c.3957G>A (p.Pro1319=) rs141730031 0.00009
NM_000834.5(GRIN2B):c.4311C>T (p.Ala1437=) rs112265127 0.00009
NM_000834.5(GRIN2B):c.513C>T (p.Ile171=) rs3026183 0.00009
NM_000834.5(GRIN2B):c.140A>G (p.Glu47Gly) rs199526748 0.00008
NM_000834.5(GRIN2B):c.3493G>A (p.Asp1165Asn) rs769857006 0.00008
NM_000834.5(GRIN2B):c.3047G>A (p.Arg1016Lys) rs141109968 0.00007
NM_000834.5(GRIN2B):c.52G>A (p.Val18Ile) rs201094029 0.00007
NM_000834.5(GRIN2B):c.3818C>A (p.Thr1273Lys) rs531747728 0.00006
NM_000834.5(GRIN2B):c.3812C>T (p.Ala1271Val) rs372379846 0.00004
NM_000834.5(GRIN2B):c.3993G>A (p.Met1331Ile) rs200035225 0.00004
NM_000834.5(GRIN2B):c.61G>A (p.Val21Met) rs79046967 0.00004
NM_000834.5(GRIN2B):c.1125G>A (p.Arg375=) rs200126922 0.00003
NM_000834.5(GRIN2B):c.275G>A (p.Arg92Gln) rs201966022 0.00003
NM_000834.5(GRIN2B):c.2845T>C (p.Tyr949His) rs201982602 0.00003
NM_000834.5(GRIN2B):c.3981G>A (p.Lys1327=) rs201670483 0.00003
NM_000834.5(GRIN2B):c.4077C>T (p.Ala1359=) rs375217280 0.00003
NM_000834.5(GRIN2B):c.4105G>A (p.Gly1369Ser) rs371190262 0.00003
NM_000834.5(GRIN2B):c.3964G>A (p.Val1322Ile) rs200255226 0.00002
NM_000834.5(GRIN2B):c.1555C>T (p.Arg519Ter) rs774592932 0.00001
NM_000834.5(GRIN2B):c.2011-8C>G rs774971411 0.00001
NM_000834.5(GRIN2B):c.2627C>T (p.Ala876Val) rs1458368988 0.00001
NM_000834.5(GRIN2B):c.381C>T (p.His127=) rs200608452 0.00001
NM_000834.5(GRIN2B):c.4049C>T (p.Ala1350Val) rs763372245 0.00001
NM_000834.5(GRIN2B):c.4108G>A (p.Gly1370Arg) rs754738111 0.00001
NM_000834.5(GRIN2B):c.1177C>T (p.Arg393Ter) rs1555112396
NM_000834.5(GRIN2B):c.1306T>C (p.Cys436Arg) rs1565478152
NM_000834.5(GRIN2B):c.1367G>A (p.Cys456Tyr) rs397514555
NM_000834.5(GRIN2B):c.1547A>G (p.Asn516Ser) rs886041295
NM_000834.5(GRIN2B):c.1556G>A (p.Arg519Gln) rs2497598118
NM_000834.5(GRIN2B):c.1619G>A (p.Arg540His) rs672601378
NM_000834.5(GRIN2B):c.1658C>T (p.Pro553Leu) rs397514556
NM_000834.5(GRIN2B):c.1672G>A (p.Val558Ile) rs1057519004
NM_000834.5(GRIN2B):c.1721TCTTTG[1] (p.574VF[1]) rs1555111511
NM_000834.5(GRIN2B):c.1806C>T (p.Ile602=) rs1805522
NM_000834.5(GRIN2B):c.1820G>C (p.Trp607Ser) rs1591638805
NM_000834.5(GRIN2B):c.1946A>G (p.Asn649Ser) rs879253945
NM_000834.5(GRIN2B):c.2002G>A (p.Asp668Asn) rs876661151
NM_000834.5(GRIN2B):c.2044C>T (p.Arg682Cys) rs387906636
NM_000834.5(GRIN2B):c.2065G>A (p.Gly689Ser) rs869312868
NM_000834.5(GRIN2B):c.2084T>C (p.Ile695Thr) rs876661219
NM_000834.5(GRIN2B):c.2116A>G (p.Met706Val) rs1057518988
NM_000834.5(GRIN2B):c.2202A>G (p.Ala734=) rs148185805
NM_000834.5(GRIN2B):c.2252T>C (p.Ile751Thr) rs876661055
NM_000834.5(GRIN2B):c.2459G>A (p.Gly820Glu) rs797044849
NM_000834.5(GRIN2B):c.2459G>C (p.Gly820Ala) rs797044849
NM_000834.5(GRIN2B):c.2471T>G (p.Met824Arg) rs1565455878
NM_000834.5(GRIN2B):c.2477G>A (p.Gly826Glu) rs1064794979
NM_000834.5(GRIN2B):c.2515G>A (p.Glu839Lys) rs1085307547
NM_000834.5(GRIN2B):c.2539C>T (p.Arg847Ter) rs879253931
NM_000834.5(GRIN2B):c.3799G>A (p.Ala1267Thr) rs141844705
NM_000834.5(GRIN2B):c.4307G>C (p.Gly1436Ala) rs1565452616
NM_000834.5(GRIN2B):c.4309G>A (p.Ala1437Thr) rs797045608
NM_000834.5(GRIN2B):c.465C>A (p.Ser155=) rs115189840
NM_000834.5(GRIN2B):c.895A>G (p.Ile299Val) rs760488868
NM_000834.5(GRIN2B):c.99dup (p.Ser34fs) rs398122823

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