ClinVar Miner

Variants in gene DOCK8 with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
2735 299 0 46 72 1 5 113

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign protective other
pathogenic 0 5 2 0 0 0 0
likely pathogenic 5 0 2 0 1 0 0
uncertain significance 3 3 0 64 14 1 1
likely benign 1 1 64 0 41 1 1
benign 0 1 13 40 0 0 0

All variants with conflicting interpretations #

Total variants: 113
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_203447.4(DOCK8):c.65C>T (p.Ala22Val) rs506121 0.32420
NM_203447.4(DOCK8):c.1238A>G (p.Asn413Ser) rs10970979 0.24995
NM_203447.4(DOCK8):c.1790C>T (p.Ala597Val) rs17673268 0.07509
NM_203447.4(DOCK8):c.5908G>C (p.Ala1970Pro) rs34908836 0.07318
NM_203447.4(DOCK8):c.3230G>A (p.Ser1077Asn) rs34627722 0.05757
NM_203447.4(DOCK8):c.3208A>G (p.Asn1070Asp) rs73382631 0.03284
NM_203447.4(DOCK8):c.709G>A (p.Glu237Lys) rs11789099 0.02275
NM_203447.4(DOCK8):c.952G>A (p.Ala318Thr) rs35482838 0.02136
NM_203447.4(DOCK8):c.3565A>G (p.Ile1189Val) rs77399114 0.02082
NM_203447.4(DOCK8):c.3840+3A>G rs16938572 0.00806
NM_203447.4(DOCK8):c.3573C>T (p.Ser1191=) rs13285348 0.00471
NM_203447.4(DOCK8):c.3701-17C>T rs376111035 0.00409
NM_203447.4(DOCK8):c.3022C>T (p.Arg1008Trp) rs16937932 0.00387
NM_203447.4(DOCK8):c.1017G>A (p.Pro339=) rs35746964 0.00360
NM_203447.4(DOCK8):c.4019A>G (p.Tyr1340Cys) rs116920018 0.00274
NM_203447.4(DOCK8):c.2310G>A (p.Glu770=) rs116175117 0.00217
NM_203447.4(DOCK8):c.1582C>A (p.Leu528Met) rs146250176 0.00213
NM_203447.4(DOCK8):c.6201A>G (p.Glu2067=) rs145573166 0.00210
NM_203447.4(DOCK8):c.528+7C>A rs114833839 0.00207
NM_203447.4(DOCK8):c.4024-4C>T rs111306749 0.00196
NM_203447.4(DOCK8):c.380G>A (p.Arg127His) rs150742426 0.00189
NM_203447.4(DOCK8):c.4158C>T (p.Asn1386=) rs77803650 0.00186
NM_203447.4(DOCK8):c.3606T>C (p.Cys1202=) rs143919622 0.00175
NM_203447.4(DOCK8):c.663C>A (p.Asp221Glu) rs139391329 0.00171
NM_203447.4(DOCK8):c.3460C>T (p.Arg1154Cys) rs34390308 0.00170
NM_203447.4(DOCK8):c.452G>A (p.Arg151Gln) rs149918318 0.00133
NM_203447.4(DOCK8):c.3234+8T>C rs112290938 0.00132
NM_203447.4(DOCK8):c.550G>A (p.Val184Met) rs143461644 0.00129
NM_203447.4(DOCK8):c.5010G>A (p.Ala1670=) rs142208336 0.00128
NM_203447.4(DOCK8):c.378C>G (p.Ile126Met) rs141175202 0.00124
NM_203447.4(DOCK8):c.4724G>A (p.Arg1575Lys) rs141252560 0.00121
NM_203447.4(DOCK8):c.3813A>G (p.Lys1271=) rs75411647 0.00115
NM_203447.4(DOCK8):c.679G>A (p.Glu227Lys) rs76276364 0.00096
NM_203447.4(DOCK8):c.1881T>C (p.Phe627=) rs140134223 0.00095
NM_203447.4(DOCK8):c.580G>A (p.Val194Ile) rs141210649 0.00092
NM_203447.4(DOCK8):c.3841-11C>T rs372829200 0.00089
NM_203447.4(DOCK8):c.4588C>G (p.Leu1530Val) rs536373496 0.00084
NM_203447.4(DOCK8):c.3988C>G (p.Leu1330Val) rs148081681 0.00076
NM_203447.4(DOCK8):c.1422+17C>T rs200839477 0.00071
NM_203447.4(DOCK8):c.541C>G (p.His181Asp) rs200684000 0.00067
NM_203447.4(DOCK8):c.494C>T (p.Ser165Leu) rs146490788 0.00061
NM_203447.4(DOCK8):c.5962-8C>T rs749575443 0.00061
NM_203447.4(DOCK8):c.3023G>A (p.Arg1008Gln) rs145844320 0.00060
NM_203447.4(DOCK8):c.3263C>T (p.Thr1088Met) rs149065013 0.00060
NM_203447.4(DOCK8):c.2971-4G>A rs186097329 0.00057
NM_203447.4(DOCK8):c.5962-9T>C rs1324502895 0.00057
NM_203447.4(DOCK8):c.4887-16C>T rs200781199 0.00056
NM_203447.4(DOCK8):c.986C>T (p.Ala329Val) rs75352090 0.00056
NM_203447.4(DOCK8):c.5155G>A (p.Ala1719Thr) rs144279637 0.00055
NM_203447.4(DOCK8):c.3312G>C (p.Glu1104Asp) rs138810908 0.00054
NM_203447.4(DOCK8):c.3058A>G (p.Ile1020Val) rs151094543 0.00046
NM_203447.4(DOCK8):c.5355+6C>T rs188141951 0.00046
NM_203447.4(DOCK8):c.54-1G>T rs192864327 0.00036
NM_203447.4(DOCK8):c.5223+4A>G rs117109271 0.00027
NM_203447.4(DOCK8):c.3519C>T (p.Ala1173=) rs144299704 0.00026
NM_203447.4(DOCK8):c.5892C>T (p.Asn1964=) rs138617736 0.00023
NM_203447.4(DOCK8):c.5818-13G>A rs368826292 0.00022
NM_203447.4(DOCK8):c.2275G>A (p.Val759Met) rs148693111 0.00021
NM_203447.4(DOCK8):c.3220C>A (p.His1074Asn) rs150298985 0.00019
NM_203447.4(DOCK8):c.4241+12G>A rs371073556 0.00019
NM_203447.4(DOCK8):c.5491-7T>A rs184867151 0.00019
NM_203447.4(DOCK8):c.53+10C>T rs763565243 0.00015
NM_203447.4(DOCK8):c.5139C>T (p.Asp1713=) rs568641163 0.00013
NM_203447.4(DOCK8):c.470C>T (p.Thr157Met) rs575314722 0.00011
NM_203447.4(DOCK8):c.3234+2T>C rs756871628 0.00010
NM_203447.4(DOCK8):c.53+11C>T rs764626266 0.00010
NM_203447.4(DOCK8):c.1036G>A (p.Val346Ile) rs148994877 0.00009
NM_203447.4(DOCK8):c.1979C>A (p.Ala660Asp) rs550289472 0.00009
NM_203447.4(DOCK8):c.3079G>A (p.Val1027Ile) rs199782622 0.00009
NM_203447.4(DOCK8):c.6064A>G (p.Met2022Val) rs143458628 0.00009
NM_203447.4(DOCK8):c.6087G>C (p.Glu2029Asp) rs371596862 0.00009
NM_203447.4(DOCK8):c.6120G>A (p.Arg2040=) rs150524921 0.00009
NM_203447.4(DOCK8):c.3543A>G (p.Val1181=) rs753242273 0.00008
NM_203447.4(DOCK8):c.1391C>A (p.Ser464Tyr) rs531279290 0.00007
NM_203447.4(DOCK8):c.1797+13A>C rs776147775 0.00006
NM_203447.4(DOCK8):c.2779A>G (p.Ile927Val) rs759239515 0.00006
NM_203447.4(DOCK8):c.4346C>T (p.Ser1449Leu) rs370123223 0.00006
NM_203447.4(DOCK8):c.1868+6T>C rs777072262 0.00005
NM_203447.4(DOCK8):c.2646G>A (p.Thr882=) rs373515697 0.00005
NM_203447.4(DOCK8):c.1098G>A (p.Thr366=) rs139297216 0.00004
NM_203447.4(DOCK8):c.2971-5C>T rs373718659 0.00004
NM_203447.4(DOCK8):c.3734C>T (p.Ser1245Leu) rs373318465 0.00004
NM_203447.4(DOCK8):c.1656A>G (p.Val552=) rs150595667 0.00003
NM_203447.4(DOCK8):c.2937C>G (p.Val979=) rs751748445 0.00003
NM_203447.4(DOCK8):c.3270T>C (p.Ile1090=) rs377297446 0.00002
NM_203447.4(DOCK8):c.4024-6G>C rs555906969 0.00002
NM_203447.4(DOCK8):c.5620G>A (p.Glu1874Lys) rs779199376 0.00002
NM_203447.4(DOCK8):c.1357G>T (p.Glu453Ter) rs113203757 0.00001
NM_203447.4(DOCK8):c.3531-10G>C rs760907119 0.00001
NM_203447.4(DOCK8):c.4241+19T>G rs2056303175 0.00001
NM_203447.4(DOCK8):c.4497G>A (p.Glu1499=) rs886063957 0.00001
NM_203447.4(DOCK8):c.4785+8G>A rs759399965 0.00001
NM_203447.4(DOCK8):c.529-10T>C rs757276569 0.00001
NM_203447.4(DOCK8):c.5481T>C (p.His1827=) rs1554708887 0.00001
NM_203447.4(DOCK8):c.5904T>A (p.Pro1968=) rs182402358 0.00001
NM_203447.4(DOCK8):c.828-15C>G rs773615177 0.00001
GRCh37/hg19 9p24.3(chr9:209753-246900)x1
NM_203447.4(DOCK8):c.1044+13G>T rs754374567
NM_203447.4(DOCK8):c.1782T>C (p.Ala594=) rs748721463
NM_203447.4(DOCK8):c.2017A>T (p.Ile673Phe) rs372858877
NM_203447.4(DOCK8):c.2440+13_2440+22del rs769837178
NM_203447.4(DOCK8):c.2444A>C (p.Asn815Thr) rs141451302
NM_203447.4(DOCK8):c.2946T>C (p.Tyr982=) rs762327114
NM_203447.4(DOCK8):c.2986C>T (p.Gln996Ter)
NM_203447.4(DOCK8):c.3175dup (p.Leu1059fs)
NM_203447.4(DOCK8):c.3195G>A (p.Arg1065=) rs781062154
NM_203447.4(DOCK8):c.3234+15del rs375864618
NM_203447.4(DOCK8):c.3612A>T (p.Lys1204Asn) rs758993681
NM_203447.4(DOCK8):c.5205C>T (p.Ala1735=) rs150682688
NM_203447.4(DOCK8):c.5962-36_5962-21del rs757203330
NM_203447.4(DOCK8):c.6022C>T (p.Arg2008Ter) rs1418593569
NM_203447.4(DOCK8):c.742-15T>G rs111627162
Single allele

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