ClinVar Miner

Variants in gene DICER1 with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic) 		Variants with a confidence conflict
(e.g. benign vs likely benign) 		Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects) 		Variants with a clinically significant conflict
(e.g. benign vs pathogenic) 		Variants with any conflict
6952 488 0 121 117 0 22 242

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 43 10 0 0
likely pathogenic 43 0 14 0 0
uncertain significance 10 14 0 113 14
likely benign 0 0 113 0 78
benign 0 0 14 78 0

All variants with conflicting interpretations #

Total variants: 242
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_177438.3(DICER1):c.4206+9G>T rs1778057 0.26377
NM_177438.3(DICER1):c.1907+105C>T rs2275182 0.21959
NM_177438.3(DICER1):c.4206+11del rs58202892 0.21617
NM_177438.3(DICER1):c.4206+9_4206+17del rs772457274 0.01738
NM_177438.3(DICER1):c.2997T>G (p.Leu999=) rs12018992 0.01637
NM_177438.3(DICER1):c.4206+9_4206+13del rs745445238 0.01449
NM_177438.3(DICER1):c.-45-4405C>T rs140969547 0.01032
NM_177438.3(DICER1):c.4206+9del rs368080354 0.01007
NM_177438.3(DICER1):c.1935G>A (p.Pro645=) rs61751177 0.00958
NM_177438.3(DICER1):c.2370G>A (p.Arg790=) rs112712209 0.00732
NM_177438.3(DICER1):c.4206+9_4206+15del rs199508452 0.00691
NM_177438.3(DICER1):c.4206+17del rs746189044 0.00689
NM_177438.3(DICER1):c.4206+11G>T rs774504706 0.00670
NM_177438.3(DICER1):c.4206+9_4206+27del rs775736832 0.00586
NM_177438.3(DICER1):c.5095+13C>T rs116247322 0.00577
NM_177438.3(DICER1):c.5241G>A (p.Ser1747=) rs114861074 0.00539
NM_177438.3(DICER1):c.1377-4T>G rs192490028 0.00240
NM_177438.3(DICER1):c.2557A>G (p.Ile853Val) rs61729795 0.00232
NM_177438.3(DICER1):c.485G>A (p.Gly162Asp) rs142815547 0.00202
NM_177438.3(DICER1):c.4206+9_4206+21del rs746597527 0.00185
NM_177438.3(DICER1):c.3972G>A (p.Lys1324=) rs45562437 0.00174
NM_177438.3(DICER1):c.2115T>C (p.Ile705=) rs140087741 0.00171
NM_177438.3(DICER1):c.1825G>T (p.Asp609Tyr) rs114947750 0.00167
NM_177438.3(DICER1):c.20A>G (p.Gln7Arg) rs117358479 0.00165
NM_177438.3(DICER1):c.4515T>C (p.Ser1505=) rs141308332 0.00164
NM_177438.3(DICER1):c.1753-43G>A rs74899136 0.00160
NM_177438.3(DICER1):c.4891T>G (p.Ser1631Ala) rs145551486 0.00128
NM_177438.3(DICER1):c.1908-4A>G rs112284114 0.00123
NM_177438.3(DICER1):c.5145C>T (p.Leu1715=) rs139500905 0.00121
NM_177438.3(DICER1):c.3213A>G (p.Arg1071=) rs148959399 0.00112
NM_177438.3(DICER1):c.4910C>T (p.Ser1637Leu) rs140875148 0.00108
NM_177438.3(DICER1):c.4014G>A (p.Ala1338=) rs143454689 0.00099
NM_177438.3(DICER1):c.2614G>A (p.Ala872Thr) rs149242330 0.00074
NM_177438.3(DICER1):c.3428T>C (p.Leu1143Pro) rs139786661 0.00070
NM_177438.3(DICER1):c.59C>T (p.Ala20Val) rs147660793 0.00070
NM_177438.3(DICER1):c.924C>T (p.Ala308=) rs142397473 0.00070
NM_177438.3(DICER1):c.5203C>T (p.Leu1735=) rs188609628 0.00059
NM_177438.3(DICER1):c.1233A>G (p.Ser411=) rs111595160 0.00051
NM_177438.3(DICER1):c.4206+11_4206+13del rs752585711 0.00045
NM_177438.3(DICER1):c.438+11T>C rs376038413 0.00044
NM_177438.3(DICER1):c.3269+14G>A rs201906274 0.00042
NM_177438.3(DICER1):c.2650+13del rs528577189 0.00033
NM_177438.3(DICER1):c.5337G>A (p.Lys1779=) rs111630745 0.00033
NM_177438.3(DICER1):c.884C>G (p.Ser295Cys) rs548231008 0.00032
NM_177438.3(DICER1):c.1124C>G (p.Pro375Arg) rs148758903 0.00027
NM_177438.3(DICER1):c.4773C>T (p.Leu1591=) rs138308365 0.00021
NM_177438.3(DICER1):c.4901T>C (p.Leu1634Ser) rs149723645 0.00021
NM_177438.3(DICER1):c.5364+20A>T rs150893725 0.00021
NM_177438.3(DICER1):c.4923T>G (p.Cys1641Trp) rs587778231 0.00019
NM_177438.3(DICER1):c.366G>A (p.Gly122=) rs368741914 0.00018
NM_177438.3(DICER1):c.4819C>T (p.Arg1607Trp) rs189119295 0.00018
NM_177438.3(DICER1):c.4207-3C>T rs376041812 0.00017
NM_177438.3(DICER1):c.3553G>A (p.Ala1185Thr) rs150514959 0.00016
NM_177438.3(DICER1):c.3820A>C (p.Arg1274=) rs142193936 0.00013
NM_177438.3(DICER1):c.4647C>T (p.His1549=) rs201415999 0.00013
NM_177438.3(DICER1):c.1543C>T (p.Leu515=) rs148218787 0.00012
NM_177438.3(DICER1):c.4802A>T (p.Lys1601Met) rs181018393 0.00012
NM_177438.3(DICER1):c.4616C>T (p.Thr1539Met) rs747901058 0.00011
NM_177438.3(DICER1):c.4804G>A (p.Ala1602Thr) rs145669719 0.00011
NM_177438.3(DICER1):c.3475G>C (p.Glu1159Gln) rs145693584 0.00010
NM_177438.3(DICER1):c.3773T>C (p.Met1258Thr) rs144095207 0.00010
NM_177438.3(DICER1):c.439-7A>T rs376762569 0.00010
NM_177438.3(DICER1):c.4870G>C (p.Ala1624Pro) rs372967646 0.00010
NM_177438.3(DICER1):c.5527+7T>A rs375239471 0.00009
NM_177438.3(DICER1):c.1692G>A (p.Ala564=) rs143117334 0.00008
NM_177438.3(DICER1):c.179C>T (p.Thr60Ile) rs587778228 0.00007
NM_177438.3(DICER1):c.2898A>G (p.Glu966=) rs375772460 0.00007
NM_177438.3(DICER1):c.3939G>A (p.Glu1313=) rs191567701 0.00007
NM_177438.3(DICER1):c.4050+8A>G rs746668314 0.00007
NM_177438.3(DICER1):c.1953T>C (p.Pro651=) rs199678028 0.00006
NM_177438.3(DICER1):c.2720T>C (p.Ile907Thr) rs200408568 0.00006
NM_177438.3(DICER1):c.3462A>C (p.Arg1154Ser) rs192822778 0.00006
NM_177438.3(DICER1):c.5276A>G (p.Lys1759Arg) rs144259142 0.00006
NM_177438.3(DICER1):c.5738A>G (p.Lys1913Arg) rs752116341 0.00006
NM_177438.3(DICER1):c.77C>T (p.Pro26Leu) rs201358110 0.00006
NM_177438.3(DICER1):c.3479C>A (p.Ser1160Tyr) rs774583162 0.00005
NM_177438.3(DICER1):c.1410G>C (p.Glu470Asp) rs774271782 0.00004
NM_177438.3(DICER1):c.1801A>G (p.Ile601Val) rs564224919 0.00004
NM_177438.3(DICER1):c.2033C>T (p.Ser678Phe) rs544623004 0.00004
NM_177438.3(DICER1):c.2658C>T (p.Asp886=) rs771049445 0.00004
NM_177438.3(DICER1):c.2951A>G (p.Asn984Ser) rs750932552 0.00004
NM_177438.3(DICER1):c.3811C>T (p.Leu1271Phe) rs1249975103 0.00004
NM_177438.3(DICER1):c.4051-4A>G rs755235399 0.00004
NM_177438.3(DICER1):c.4554T>A (p.Val1518=) rs752773026 0.00004
NM_177438.3(DICER1):c.4889G>A (p.Arg1630His) rs368343829 0.00004
NM_177438.3(DICER1):c.897G>A (p.Ser299=) rs201842071 0.00004
NM_177438.3(DICER1):c.1329C>T (p.Cys443=) rs776143079 0.00003
NM_177438.3(DICER1):c.1381A>G (p.Ile461Val) rs141163928 0.00003
NM_177438.3(DICER1):c.1583T>C (p.Ile528Thr) rs143099538 0.00003
NM_177438.3(DICER1):c.1795A>G (p.Thr599Ala) rs766492523 0.00003
NM_177438.3(DICER1):c.1883A>G (p.Asn628Ser) rs756051157 0.00003
NM_177438.3(DICER1):c.2133T>C (p.His711=) rs878855248 0.00003
NM_177438.3(DICER1):c.2553G>A (p.Gln851=) rs373715574 0.00003
NM_177438.3(DICER1):c.3210A>G (p.Leu1070=) rs547156371 0.00003
NM_177438.3(DICER1):c.3823A>G (p.Met1275Val) rs751764482 0.00003
NM_177438.3(DICER1):c.4894T>C (p.Ser1632Pro) rs545392797 0.00003
NM_177438.3(DICER1):c.1423A>T (p.Ser475Cys) rs1060503594 0.00002
NM_177438.3(DICER1):c.184G>A (p.Val62Ile) rs746671039 0.00002
NM_177438.3(DICER1):c.255C>G (p.Ile85Met) rs763422772 0.00002
NM_177438.3(DICER1):c.3334A>G (p.Asn1112Asp) rs587778229 0.00002
NM_177438.3(DICER1):c.354T>C (p.Asp118=) rs538838304 0.00002
NM_177438.3(DICER1):c.3640A>G (p.Thr1214Ala) rs776023608 0.00002
NM_177438.3(DICER1):c.3728T>C (p.Leu1243Pro) rs561584807 0.00002
NM_177438.3(DICER1):c.4199A>G (p.Asp1400Gly) rs139536688 0.00002
NM_177438.3(DICER1):c.4407T>C (p.Leu1469=) rs540502223 0.00002
NM_177438.3(DICER1):c.4449G>A (p.Met1483Ile) rs1454569806 0.00002
NM_177438.3(DICER1):c.4475T>C (p.Met1492Thr) rs370947079 0.00002
NM_177438.3(DICER1):c.4740G>T (p.Gln1580His) rs369465519 0.00002
NM_177438.3(DICER1):c.4888C>T (p.Arg1630Cys) rs549532374 0.00002
NM_177438.3(DICER1):c.5516G>A (p.Arg1839Gln) rs587778233 0.00002
NM_177438.3(DICER1):c.773G>T (p.Gly258Val) rs188327838 0.00002
NM_177438.3(DICER1):c.996C>T (p.Tyr332=) rs757094384 0.00002
NM_177438.3(DICER1):c.1080A>G (p.Glu360=) rs886050943 0.00001
NM_177438.3(DICER1):c.1140G>C (p.Leu380=) rs745464699 0.00001
NM_177438.3(DICER1):c.128C>T (p.Thr43Met) rs367797765 0.00001
NM_177438.3(DICER1):c.132A>G (p.Pro44=) rs1595468557 0.00001
NM_177438.3(DICER1):c.141T>C (p.Tyr47=) rs1313430297 0.00001
NM_177438.3(DICER1):c.1430A>G (p.Asn477Ser) rs1060503630 0.00001
NM_177438.3(DICER1):c.1449C>T (p.Gly483=) rs569346627 0.00001
NM_177438.3(DICER1):c.159A>G (p.Glu53=) rs2140289208 0.00001
NM_177438.3(DICER1):c.1631G>A (p.Arg544Gln) rs143533680 0.00001
NM_177438.3(DICER1):c.1681A>G (p.Ile561Val) rs147493562 0.00001
NM_177438.3(DICER1):c.1802T>C (p.Ile601Thr) rs760966585 0.00001
NM_177438.3(DICER1):c.192A>T (p.Leu64Phe) rs1231822339 0.00001
NM_177438.3(DICER1):c.2496G>C (p.Lys832Asn) rs769292296 0.00001
NM_177438.3(DICER1):c.3162C>T (p.Leu1054=) rs1060504987 0.00001
NM_177438.3(DICER1):c.3329T>G (p.Ile1110Ser) rs759760077 0.00001
NM_177438.3(DICER1):c.3459C>T (p.Cys1153=) rs1300692476 0.00001
NM_177438.3(DICER1):c.3474C>T (p.Ser1158=) rs368984998 0.00001
NM_177438.3(DICER1):c.3805C>G (p.Gln1269Glu) rs1277796753 0.00001
NM_177438.3(DICER1):c.3987A>G (p.Thr1329=) rs373810197 0.00001
NM_177438.3(DICER1):c.406G>C (p.Glu136Gln) rs768445477 0.00001
NM_177438.3(DICER1):c.4104C>A (p.Arg1368=) rs779443466 0.00001
NM_177438.3(DICER1):c.4189T>C (p.Trp1397Arg) rs762677393 0.00001
NM_177438.3(DICER1):c.4251C>T (p.Tyr1417=) rs763063055 0.00001
NM_177438.3(DICER1):c.4283T>A (p.Met1428Lys) rs996633792 0.00001
NM_177438.3(DICER1):c.4412C>T (p.Pro1471Leu) rs1060503657 0.00001
NM_177438.3(DICER1):c.4911G>A (p.Ser1637=) rs1447821588 0.00001
NM_177438.3(DICER1):c.4945A>G (p.Met1649Val) rs146715213 0.00001
NM_177438.3(DICER1):c.5010A>G (p.Glu1670=) rs886050940 0.00001
NM_177438.3(DICER1):c.5187G>A (p.Pro1729=) rs765113010 0.00001
NM_177438.3(DICER1):c.5217G>C (p.Leu1739=) rs774703353 0.00001
NM_177438.3(DICER1):c.5365-9C>T rs778669119 0.00001
NM_177438.3(DICER1):c.5529A>G (p.Glu1843=) rs768311617 0.00001
NM_177438.3(DICER1):c.5623G>A (p.Asp1875Asn) rs745601023 0.00001
NM_177438.3(DICER1):c.5626G>A (p.Gly1876Arg) rs770962059 0.00001
NM_177438.3(DICER1):c.5652A>G (p.Val1884=) rs780084290 0.00001
NM_177438.3(DICER1):c.574-7_574-5del rs753080447 0.00001
NM_177438.3(DICER1):c.5762A>G (p.Asn1921Ser) rs764747360 0.00001
NM_177438.3(DICER1):c.742T>A (p.Ser248Thr) rs759633210 0.00001
NM_177438.3(DICER1):c.854A>G (p.Asn285Ser) rs748847398 0.00001
NM_177438.3(DICER1):c.1089C>T (p.Phe363=) rs878855239
NM_177438.3(DICER1):c.1174C>T (p.Arg392Ter) rs1131691211
NM_177438.3(DICER1):c.1230G>T (p.Val410=) rs1481644631
NM_177438.3(DICER1):c.145-22dup rs558991368
NM_177438.3(DICER1):c.145-4C>T rs1595466756
NM_177438.3(DICER1):c.1509+16A>G rs201947254
NM_177438.3(DICER1):c.1509G>C (p.Glu503Asp) rs1595414866
NM_177438.3(DICER1):c.1510-4del rs546524688
NM_177438.3(DICER1):c.1598del (p.Leu533fs) rs2543033749
NM_177438.3(DICER1):c.1642C>T (p.Gln548Ter) rs2140124358
NM_177438.3(DICER1):c.1752+213A>G rs2543019173
NM_177438.3(DICER1):c.1797T>C (p.Thr599=) rs761971773
NM_177438.3(DICER1):c.1907+3A>T rs759764582
NM_177438.3(DICER1):c.2040+54dup rs141723381
NM_177438.3(DICER1):c.2166T>G (p.Tyr722Ter) rs1595391320
NM_177438.3(DICER1):c.2191G>A (p.Glu731Lys) rs869025262
NM_177438.3(DICER1):c.2233C>T (p.Arg745Ter) rs1060503584
NM_177438.3(DICER1):c.2236A>G (p.Arg746Gly) rs886037686
NM_177438.3(DICER1):c.2256+5G>A rs1595390864
NM_177438.3(DICER1):c.2256+5G>C rs1595390864
NM_177438.3(DICER1):c.2257-2A>G rs2140034081
NM_177438.3(DICER1):c.238G>T (p.Glu80Ter) rs1595466234
NM_177438.3(DICER1):c.2461C>T (p.Arg821Cys) rs1891611876
NM_177438.3(DICER1):c.2516C>T (p.Ser839Phe) rs387906934
NM_177438.3(DICER1):c.2521C>T (p.Gln841Ter) rs2542841694
NM_177438.3(DICER1):c.2551C>T (p.Gln851Ter) rs2542840500
NM_177438.3(DICER1):c.2642T>C (p.Leu881Pro) rs1595380007
NM_177438.3(DICER1):c.2650+1G>C
NM_177438.3(DICER1):c.2651-14T>G rs753857234
NM_177438.3(DICER1):c.265_266del (p.Phe89fs) rs1894040158
NM_177438.3(DICER1):c.2698dup (p.Ile900fs) rs2140020024
NM_177438.3(DICER1):c.2752A>G (p.Thr918Ala) rs377326167
NM_177438.3(DICER1):c.2916T>C (p.Tyr972=) rs1488644936
NM_177438.3(DICER1):c.2987+1G>A rs1555370248
NM_177438.3(DICER1):c.3094-8_3094-5del rs770904411
NM_177438.3(DICER1):c.3111C>G (p.Leu1037=) rs1488681878
NM_177438.3(DICER1):c.3111_3112del (p.Ala1039fs)
NM_177438.3(DICER1):c.3151G>C (p.Ala1051Pro) rs1595371059
NM_177438.3(DICER1):c.3269+1G>A rs1595370466
NM_177438.3(DICER1):c.3270-1G>C rs2139972425
NM_177438.3(DICER1):c.3279_3282del (p.Asn1093fs) rs2542723228
NM_177438.3(DICER1):c.3304_3311delinsT (p.Ile1102fs) rs1891190597
NM_177438.3(DICER1):c.3353dup (p.Asn1118fs) rs2542719254
NM_177438.3(DICER1):c.3546A>G (p.Gln1182=) rs1566768449
NM_177438.3(DICER1):c.3690G>A (p.Gln1230=) rs1555369473
NM_177438.3(DICER1):c.3990T>A (p.Tyr1330Ter)
NM_177438.3(DICER1):c.4102dup (p.Arg1368fs) rs1890722878
NM_177438.3(DICER1):c.4206+3_4206+5del rs2542597073
NM_177438.3(DICER1):c.4206+7_4206+8dup rs1555368535
NM_177438.3(DICER1):c.4206+8_4206+9insTTTGTG rs763704682
NM_177438.3(DICER1):c.4206+9GT[13] rs71838494
NM_177438.3(DICER1):c.4206+9GT[19] rs71838494
NM_177438.3(DICER1):c.4206+9GT[21] rs71838494
NM_177438.3(DICER1):c.4254GGA[2] (p.Glu1420del) rs544960260
NM_177438.3(DICER1):c.4405_4406del (p.Leu1469fs) rs1064795904
NM_177438.3(DICER1):c.4458dup (p.Ser1487fs) rs1131691197
NM_177438.3(DICER1):c.4469dup (p.Gly1490_Ser1491insTer)
NM_177438.3(DICER1):c.4506C>T (p.Asp1502=) rs1595341062
NM_177438.3(DICER1):c.4638C>G (p.Tyr1546Ter) rs773822569
NM_177438.3(DICER1):c.4748T>G (p.Leu1583Arg) rs137852976
NM_177438.3(DICER1):c.4762del (p.Gly1587_Leu1588insTer) rs1566754840
NM_177438.3(DICER1):c.4795C>T (p.Arg1599Trp) rs587778230
NM_177438.3(DICER1):c.4806C>T (p.Ala1602=) rs1890302137
NM_177438.3(DICER1):c.4874C>A (p.Ser1625Tyr) rs864622653
NM_177438.3(DICER1):c.4889G>T (p.Arg1630Leu) rs368343829
NM_177438.3(DICER1):c.5096-12G>A rs1566750865
NM_177438.3(DICER1):c.5123G>A (p.Gly1708Glu) rs886037724
NM_177438.3(DICER1):c.5126A>G (p.Asp1709Gly) rs1555366979
NM_177438.3(DICER1):c.5138A>T (p.Asp1713Val) rs1595331224
NM_177438.3(DICER1):c.5365-4A>G rs754838493
NM_177438.3(DICER1):c.5425G>A (p.Gly1809Arg) rs1595314951
NM_177438.3(DICER1):c.5425G>C (p.Gly1809Arg) rs1595314951
NM_177438.3(DICER1):c.5428G>C (p.Asp1810His) rs775912475
NM_177438.3(DICER1):c.5428G>T (p.Asp1810Tyr) rs775912475
NM_177438.3(DICER1):c.5438A>C (p.Glu1813Ala) rs1889806272
NM_177438.3(DICER1):c.5438A>G (p.Glu1813Gly) rs1889806272
NM_177438.3(DICER1):c.5441C>T (p.Ser1814Leu) rs1060503625
NM_177438.3(DICER1):c.5452G>A (p.Ala1818Thr) rs1889802883
NM_177438.3(DICER1):c.5465A>G (p.Asp1822Gly) rs886037729
NM_177438.3(DICER1):c.5465A>T (p.Asp1822Val) rs886037729
NM_177438.3(DICER1):c.5574T>G (p.Leu1858=)
NM_177438.3(DICER1):c.5656G>A (p.Gly1886Arg) rs1566744851
NM_177438.3(DICER1):c.590dup (p.Ser198fs)
NM_177438.3(DICER1):c.734+3A>T rs377208116
NM_177438.3(DICER1):c.734+4T>A rs866993296
NM_177438.3(DICER1):c.735-1_741delinsA rs886037731
NM_177438.3(DICER1):c.745C>T (p.Gln249Ter) rs886037732
NM_177438.3(DICER1):c.832C>T (p.Leu278Phe) rs768248216
NM_177438.3(DICER1):c.904-1G>C rs1566803555
NM_177438.3(DICER1):c.904-5del rs769549511
NM_177438.3(DICER1):c.936del (p.Leu313fs)

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