ClinVar Miner

Variants in gene BAG3 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
1132 171 0 44 56 0 3 98

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 9 0 0 0
likely pathogenic 9 0 3 0 0
uncertain significance 0 3 0 55 6
likely benign 0 0 55 0 35
benign 0 0 6 35 0

All variants with conflicting interpretations #

Total variants: 98
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_004281.4(BAG3):c.451T>C (p.Cys151Arg) rs2234962 0.14532
NM_004281.4(BAG3):c.231G>A (p.Pro77=) rs143752613 0.00441
NM_004281.4(BAG3):c.-294A>C rs544280047 0.00385
NM_004281.4(BAG3):c.249C>A (p.His83Gln) rs151331972 0.00344
NM_004281.4(BAG3):c.606G>T (p.Pro202=) rs74157690 0.00341
NM_004281.4(BAG3):c.181-9T>A rs139232658 0.00317
NM_004281.4(BAG3):c.187C>G (p.Pro63Ala) rs144041999 0.00311
NM_004281.4(BAG3):c.1138C>T (p.Pro380Ser) rs144692954 0.00310
NM_004281.4(BAG3):c.-293T>A rs557535632 0.00284
NM_004281.4(BAG3):c.463G>A (p.Ala155Thr) rs61756328 0.00239
NM_004281.4(BAG3):c.-17G>A rs200388926 0.00218
NM_004281.4(BAG3):c.25A>G (p.Met9Val) rs137965903 0.00175
NM_004281.4(BAG3):c.1587C>T (p.Ala529=) rs149358702 0.00144
NM_004281.4(BAG3):c.549C>G (p.Ser183=) rs112929734 0.00141
NM_004281.4(BAG3):c.1436C>T (p.Ala479Val) rs34656239 0.00097
NM_004281.4(BAG3):c.1503C>A (p.Val501=) rs147277075 0.00089
NM_004281.4(BAG3):c.280A>T (p.Ile94Phe) rs145393807 0.00075
NM_004281.4(BAG3):c.870C>G (p.Pro290=) rs140737221 0.00055
NM_004281.4(BAG3):c.855G>A (p.Thr285=) rs147259596 0.00048
NM_004281.4(BAG3):c.888C>T (p.His296=) rs139399890 0.00037
NM_004281.3(BAG3):c.772C>T (p.Arg258Trp) rs117671123 0.00036
NM_004281.4(BAG3):c.821C>T (p.Ser274Leu) rs143919208 0.00035
NM_004281.4(BAG3):c.230C>T (p.Pro77Leu) rs141355480 0.00030
NM_004281.4(BAG3):c.771C>T (p.Pro257=) rs200212999 0.00027
NM_004281.4(BAG3):c.898G>A (p.Asp300Asn) rs78439745 0.00026
NM_004281.4(BAG3):c.1240G>A (p.Glu414Lys) rs117749531 0.00024
NM_004281.4(BAG3):c.1674G>A (p.Ala558=) rs142981190 0.00021
NM_004281.4(BAG3):c.653G>A (p.Arg218Gln) rs201638005 0.00018
NM_004281.4(BAG3):c.96G>T (p.Pro32=) rs372083121 0.00017
NM_004281.4(BAG3):c.1588G>A (p.Val530Met) rs144678100 0.00016
NM_004281.4(BAG3):c.1634C>G (p.Pro545Arg) rs759348679 0.00014
NM_004281.4(BAG3):c.1029C>A (p.Arg343=) rs117972572 0.00013
NM_004281.4(BAG3):c.415C>T (p.Arg139Trp) rs556465096 0.00011
NM_004281.4(BAG3):c.1321A>G (p.Asn441Asp) rs201181493 0.00009
NM_004281.4(BAG3):c.554C>T (p.Ser185Leu) rs730880054 0.00009
NM_004281.4(BAG3):c.-4C>T rs727502894 0.00007
NM_004281.4(BAG3):c.181-15C>T rs397516882 0.00007
NM_004281.4(BAG3):c.211C>T (p.Arg71Trp) rs387906874 0.00007
NM_004281.4(BAG3):c.470C>T (p.Ala157Val) rs541080567 0.00007
NM_004281.4(BAG3):c.574G>A (p.Gly192Ser) rs201487919 0.00007
NM_004281.4(BAG3):c.827G>A (p.Arg276Gln) rs372970842 0.00007
NM_004281.4(BAG3):c.892G>A (p.Val298Met) rs150048651 0.00007
NM_004281.4(BAG3):c.1166G>A (p.Ser389Asn) rs140251789 0.00006
NM_004281.4(BAG3):c.1523A>G (p.Tyr508Cys) rs747583925 0.00006
NM_004281.4(BAG3):c.167C>G (p.Ser56Cys) rs777100532 0.00006
NM_004281.4(BAG3):c.400T>A (p.Ser134Thr) rs375257731 0.00006
NM_004281.4(BAG3):c.487C>T (p.Pro163Ser) rs746956979 0.00006
NM_004281.4(BAG3):c.652C>T (p.Arg218Trp) rs397514506 0.00006
NM_004281.4(BAG3):c.693G>A (p.Thr231=) rs144034433 0.00006
NM_004281.4(BAG3):c.785C>T (p.Ala262Val) rs397516883 0.00006
NM_004281.4(BAG3):c.133C>T (p.Arg45Cys) rs747820097 0.00005
NM_004281.4(BAG3):c.872C>T (p.Ser291Leu) rs368866313 0.00005
NM_004281.4(BAG3):c.34G>A (p.Val12Met) rs367917821 0.00004
NM_004281.4(BAG3):c.627G>A (p.Pro209=) rs188555685 0.00004
NM_004281.4(BAG3):c.679C>G (p.Gln227Glu) rs149517238 0.00004
NM_004281.4(BAG3):c.483G>A (p.Gln161=) rs758279156 0.00003
NM_004281.4(BAG3):c.509G>A (p.Arg170Gln) rs140904592 0.00003
NM_004281.4(BAG3):c.781C>T (p.Arg261Trp) rs548032105 0.00003
NM_004281.4(BAG3):c.926G>A (p.Arg309Gln) rs774137001 0.00003
NM_004281.4(BAG3):c.1411G>A (p.Glu471Lys) rs778496291 0.00002
NM_004281.4(BAG3):c.386C>T (p.Ala129Val) rs876657747 0.00002
NM_004281.4(BAG3):c.897C>T (p.Val299=) rs763915884 0.00002
NM_004281.4(BAG3):c.983T>C (p.Val328Ala) rs765627299 0.00002
NM_004281.4(BAG3):c.1179A>G (p.Glu393=) rs780963692 0.00001
NM_004281.4(BAG3):c.1184G>A (p.Arg395Lys) rs111787446 0.00001
NM_004281.4(BAG3):c.1202C>G (p.Ala401Gly) rs775153939 0.00001
NM_004281.4(BAG3):c.1418G>A (p.Arg473Gln) rs150156178 0.00001
NM_004281.4(BAG3):c.1447G>A (p.Gly483Ser) rs570294713 0.00001
NM_004281.4(BAG3):c.1571T>C (p.Ile524Thr) rs752390475 0.00001
NM_004281.4(BAG3):c.1651C>A (p.Gln551Lys) rs577455773 0.00001
NM_004281.4(BAG3):c.367C>T (p.Arg123Ter) rs387906875 0.00001
NM_004281.4(BAG3):c.465A>G (p.Ala155=) rs775151738 0.00001
NM_004281.4(BAG3):c.67C>T (p.Pro23Ser) rs747846089 0.00001
NM_004281.4(BAG3):c.910-2A>C rs762944997 0.00001
NM_004281.4(BAG3):c.988C>T (p.Pro330Ser) rs762376423 0.00001
NM_004281.4(BAG3):c.997C>T (p.Pro333Ser) rs1393181351 0.00001
NM_004281.4(BAG3):c.1131_1134del (p.Ser377fs) rs2494023044
NM_004281.4(BAG3):c.1174A>G (p.Thr392Ala) rs2134068984
NM_004281.4(BAG3):c.1257dup (p.Pro420fs) rs2134069115
NM_004281.4(BAG3):c.1430G>A (p.Arg477His) rs387906876
NM_004281.4(BAG3):c.1541A>G (p.Asn514Ser) rs1564776999
NM_004281.4(BAG3):c.1543C>T (p.Leu515Phe) rs2494024470
NM_004281.4(BAG3):c.1554T>A (p.Asp518Glu) rs139125612
NM_004281.4(BAG3):c.212G>A (p.Arg71Gln) rs35434411
NM_004281.4(BAG3):c.212G>T (p.Arg71Leu) rs35434411
NM_004281.4(BAG3):c.361C>T (p.Arg121Ter) rs2134063421
NM_004281.4(BAG3):c.460G>A (p.Val154Met) rs376198104
NM_004281.4(BAG3):c.467C>G (p.Ala156Gly) rs572038196
NM_004281.4(BAG3):c.468GGC[4] (p.Ala160dup) rs139438727
NM_004281.4(BAG3):c.49G>C (p.Gly17Arg) rs727502895
NM_004281.4(BAG3):c.534C>G (p.Asp178Glu) rs1847160690
NM_004281.4(BAG3):c.612G>A (p.Gly204=) rs2134065088
NM_004281.4(BAG3):c.625C>T (p.Pro209Ser) rs1589630141
NM_004281.4(BAG3):c.699C>A (p.Tyr233Ter) rs876661342
NM_004281.4(BAG3):c.72dup (p.Gly25fs) rs727502897
NM_004281.4(BAG3):c.751C>T (p.Gln251Ter) rs1343231277
NM_004281.4(BAG3):c.77G>A (p.Trp26Ter) rs1554875409
NM_004281.4(BAG3):c.782G>A (p.Arg261Gln) rs746454994

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