Variants from Foulkes Cancer Genetics LDI, Lady Davis Institute for Medical Research

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
345	30	95	44	18	531

Gene and significance breakdown #

Total genes and gene combinations: 5

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Gene or gene combination	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
DICER1	249	23	36	25	1	333
BRCA2	44	3	40	8	8	103
BRCA1	42	4	17	11	6	80
BRCA1, LOC126862571	10	0	2	0	2	14
BRCA1, LOC111589215	0	0	0	0	1	1

Condition and significance breakdown #

Total conditions: 6

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Condition	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
DICER1-related tumor predisposition	242	17	1	0	0	260
Breast and/or ovarian cancer	96	7	59	15	17	194
not specified	7	4	35	25	1	71
Breast-ovarian cancer, familial, susceptibility to, 1	0	0	0	2	0	2
Breast-ovarian cancer, familial, susceptibility to, 2	0	0	0	2	0	2
Pleuropulmonary blastoma	0	2	0	0	0	2

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