ClinVar Miner

Variants studied for GM1 gangliosidosis

Included ClinVar conditions (9):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
201 171 244 510 33 30 1051

Gene and significance breakdown #

Total genes and gene combinations: 3
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
GLB1 195 165 229 480 30 28 993
GLB1, LOC129936434, TMPPE 6 6 14 30 3 2 57
GLB1, LOC129936434 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 46
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 179 67 157 498 26 0 927
Counsyl 9 41 34 3 0 0 87
Fulgent Genetics, Fulgent Genetics 27 38 5 0 0 0 70
Illumina Laboratory Services, Illumina 3 2 36 9 7 0 57
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 23 15 0 0 0 0 38
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 7 8 5 0 0 0 20
OMIM 20 0 0 0 0 0 20
GenomeConnect - GM1 0 0 0 0 0 19 19
Pars Genome Lab 0 0 0 3 12 0 15
Neuberg Centre For Genomic Medicine, NCGM 6 4 5 0 0 0 14
Kasturba Medical College, Manipal, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India 9 2 1 0 0 0 12
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 7 2 3 0 0 0 12
Baylor Genetics 6 1 2 0 0 0 9
Genome-Nilou Lab 1 0 4 1 3 0 9
3billion 3 2 2 1 0 0 8
Mendelics 5 1 1 0 0 0 7
GeneReviews 0 0 0 0 0 6 6
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 2 0 4 0 0 0 6
Laboratory of Molecular Genetics MedGen 0 0 0 0 0 6 6
Dubai Health Genomic Medicine Center, Dubai Health 1 3 0 0 0 0 4
First Genomix Gene Laboratory, Genetic Diagnostics Department 3 1 0 0 0 0 4
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 4 0 0 0 0 0 4
CENTOGENE GmbH and LLC - Guiding Precision Medicine 3 0 0 0 0 0 3
Department of Pathology and Laboratory Medicine, Sinai Health System 1 0 2 0 0 0 3
Juno Genomics, Hangzhou Juno Genomics, Inc 2 1 0 0 0 0 3
Laboratory of Medical Genetics, National & Kapodistrian University of Athens 2 1 0 0 0 0 3
Unidad de Diagnostico y Tratamiento de Errores Congenitos del Metabolismo. Hospital Clínico Universitário de Santiago de Compostela 3 0 0 0 0 0 3
Department of Genetics, Rouen University Hospital, Normandy Center for Genomic and Personalized Medicine 2 0 0 0 0 0 2
Genetics and Genomic Medicine Centre, NeuroGen Healthcare, NeuroGen Healthcare 2 0 0 0 0 0 2
Genomic Research Center, Shahid Beheshti University of Medical Sciences 1 1 0 0 0 0 2
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 2 0 0 0 0 0 2
Institute of Human Genetics Munich, TUM University Hospital 2 0 0 0 0 0 2
MGZ Medical Genetics Center 1 1 0 0 0 0 2
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 2 0 0 0 0 0 2
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 0 1 0 0 0 0 1
Biological Sciences, International Islamic University, Islamabad 1 0 0 0 0 0 1
Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences 0 1 0 0 0 0 1
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 1 0 0 0 0 1
Department of Human Genetics, Hannover Medical School 0 1 0 0 0 0 1
Department of Medical Genetics, All India Institute of Medical Sciences, Bhopal 0 1 0 0 0 0 1
Division of Human Genetics, Children's Hospital of Philadelphia 0 1 0 0 0 0 1
Dr. Faghihi's Medical Genetic Center 1 0 0 0 0 0 1
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 1 0 0 0 0 0 1
Myelin Disorders Clinic-Children's Medical Center/Medical Genetics Lab-Tarbiat Modares University, Children's Medical Center, Pediatrics Center of Excellence, 0 0 1 0 0 0 1
Service de Génétique Médicale, Centre Hospitalier Universitaire de Nice-Université Côte d'Azur 0 1 0 0 0 0 1
UCLA Clinical Genomics Center, UCLA 1 0 0 0 0 0 1

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