ClinVar Miner

Variants in gene WRN

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
310 221 1995 1302 171 98 3821

Condition and significance breakdown #

Total conditions: 39
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Werner syndrome 307 211 1946 1210 102 15 3650
not provided 13 10 82 111 90 3 286
Inborn genetic diseases 0 0 132 14 0 0 146
not specified 1 0 22 30 29 43 92
WRN-related disorder 1 1 23 30 3 0 58
Wiskott-Aldrich syndrome 0 0 0 6 23 0 29
Ovarian cancer 0 4 0 0 9 1 14
Familial cancer of breast 0 0 0 0 0 7 7
Sarcoma 0 0 0 0 0 7 7
Gastric cancer 0 0 0 0 0 6 6
Malignant tumor of esophagus 0 0 0 0 0 6 6
Acute myeloid leukemia 0 0 0 0 0 5 5
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 5 5
Cervical cancer 0 0 0 0 0 4 4
Lung cancer 0 0 0 0 0 4 4
Melanoma 0 0 0 0 0 4 4
Thymoma 0 0 0 0 0 4 4
Colon adenocarcinoma 0 0 0 0 0 3 3
Colorectal cancer 0 0 0 0 0 3 3
Ovarian serous cystadenocarcinoma 0 0 0 0 0 3 3
Uterine carcinosarcoma 0 0 0 0 0 3 3
Chronic lymphocytic leukemia/small lymphocytic lymphoma 0 0 0 0 0 2 2
Clear cell carcinoma of kidney 0 0 0 0 0 2 2
Familial pancreatic carcinoma 0 0 0 0 0 2 2
Hepatocellular carcinoma 0 0 0 0 0 2 2
Nonpapillary renal cell carcinoma 0 0 0 0 0 2 2
Cholangiocarcinoma 0 0 0 0 0 1 1
Familial prostate cancer 0 0 0 0 0 1 1
Glioma susceptibility 1 0 0 0 0 0 1 1
Hereditary cancer 0 0 0 1 0 0 1
Lymphoma 0 0 0 0 0 1 1
Malignant tumor of breast 0 0 0 0 1 0 1
Malignant tumor of urinary bladder 0 0 0 0 0 1 1
Medulloblastoma 0 1 0 0 0 0 1
Papillary renal cell carcinoma type 1 0 0 0 0 0 1 1
Progressive pulmonary failure 0 1 0 0 0 0 1
Squamous cell lung carcinoma 0 0 0 0 0 1 1
Type 2 diabetes mellitus; Short stature; Cataract; Convex nasal ridge; Mask-like facies; Decreased body weight 0 1 0 0 0 0 1
Uterine corpus endometrial carcinoma 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 58
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 285 104 1860 1194 85 0 3528
GeneDx 2 1 30 49 85 0 167
Baylor Genetics 31 96 21 0 0 0 148
Ambry Genetics 0 0 132 14 0 0 146
Illumina Laboratory Services, Illumina 1 3 86 12 18 0 120
Fulgent Genetics, Fulgent Genetics 12 24 78 0 1 0 115
PreventionGenetics, part of Exact Sciences 1 1 23 30 19 0 74
CeGaT Center for Human Genetics Tuebingen 5 7 7 50 0 0 69
Breakthrough Genomics, Breakthrough Genomics 0 0 7 18 41 0 66
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 45 45
ITMI 0 0 0 0 0 43 43
Mayo Clinic Laboratories, Mayo Clinic 0 1 10 10 19 0 40
Genome-Nilou Lab 0 0 0 0 38 0 38
Eurofins Ntd Llc (ga) 2 0 22 6 6 0 36
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 6 32 0 36
Genetic Services Laboratory, University of Chicago 1 0 8 20 2 0 31
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 6 5 12 4 2 0 29
Revvity Omics, Revvity 4 3 18 0 0 0 25
Department of Pathology and Laboratory Medicine, Sinai Health System 0 3 10 4 0 0 17
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 2 0 14 0 1 0 17
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 4 0 0 9 0 13
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 1 0 2 9 0 0 12
Genome Diagnostics Laboratory, Amsterdam University Medical Center 2 0 1 7 1 0 11
OMIM 10 0 0 0 0 0 10
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 9 9
Mendelics 1 1 2 2 3 0 9
Dasa 2 0 2 2 1 0 7
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 1 6 0 7
GeneReviews 0 0 0 0 0 7 7
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 1 0 0 0 6 0 7
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 2 1 1 1 0 6
3billion 2 1 0 2 0 0 5
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 0 3 0 0 0 0 3
Institute of Human Genetics, University of Leipzig Medical Center 2 0 1 0 0 0 3
Laboratory of Genetics, Children's Clinical University Hospital Latvia 0 0 0 3 0 0 3
ARUP Laboratories, Cytogenetics and Genomic Microarray, ARUP Laboratories 1 0 1 0 0 0 2
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 0 2 0 0 0 2
Centre for Mendelian Genomics, University Medical Centre Ljubljana 1 1 1 0 0 0 2
Clinical Genetics Laboratory, Skane University Hospital Lund 1 1 0 0 0 0 2
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 2 0 0 0 0 0 2
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 1 1 0 0 2
Medical and Scientific Branch, Hong Kong Genome Institute 1 1 0 0 0 0 2
Molecular Genetics Laboratory, BC Children's and BC Women's Hospitals 1 0 0 0 1 0 2
Neuberg Centre For Genomic Medicine, NCGM 1 0 1 0 0 0 2
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 0 1 0 0 0 0 1
Center for Individualized Medicine, Mayo Clinic 0 1 0 0 0 0 1
Center of Medical Genetics and Primary Health Care 0 0 0 0 1 0 1
Clinical Genetics Unit, University Hospital Principe de Asturias 1 0 0 0 0 0 1
Department of Medical Genetics, Gazi University 0 1 0 0 0 0 1
Division of Genomic Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University 1 0 0 0 0 0 1
First Genomix Gene Laboratory, Genetic Diagnostics Department 1 0 0 0 0 0 1
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 0 1 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Institute of Human Genetics Munich, TUM University Hospital 1 0 0 0 0 0 1
OLLIN Analises Genomicas, OLLIN 0 1 0 0 0 0 1
SNPedia 0 0 0 0 0 1 1
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 1 0 0 0 0 1
UNC Molecular Genetics Laboratory, University of North Carolina at Chapel Hill 0 1 0 0 0 0 1

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