ClinVar Miner

Variants in gene WNK1

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
64 21 1404 828 196 43 2364

Condition and significance breakdown #

Total conditions: 36
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Neuropathy, hereditary sensory and autonomic, type 2A; Pseudohypoaldosteronism type 2C 38 13 1188 718 66 2 1987
not provided 5 4 172 137 110 1 410
Inborn genetic diseases 6 0 201 41 0 0 248
Pseudohypoaldosteronism type 2C 1 4 86 16 102 1 209
not specified 0 0 32 37 54 0 116
Neuropathy, hereditary sensory and autonomic, type 2A 26 3 12 0 21 4 62
WNK1-related disorder 0 0 14 19 2 0 35
Malignant tumor of urinary bladder 0 0 0 0 0 6 6
Charcot-Marie-Tooth disease 0 0 5 0 0 0 5
Malignant tumor of esophagus 0 0 0 0 0 5 5
Acute myeloid leukemia 0 0 0 0 0 4 4
Familial cancer of breast 0 0 0 0 0 4 4
Sarcoma 0 0 0 0 0 4 4
Cervical cancer 0 0 0 0 0 3 3
Clear cell carcinoma of kidney 0 0 0 0 0 3 3
Ovarian serous cystadenocarcinoma 0 0 0 0 0 3 3
Uterine corpus endometrial carcinoma 0 0 0 0 0 3 3
Hepatocellular carcinoma 0 0 0 0 0 2 2
Papillary renal cell carcinoma type 1 0 0 0 0 0 2 2
Variant of unknown significance 0 0 2 0 0 0 2
Cholangiocarcinoma 0 0 0 0 0 1 1
Colon adenocarcinoma 0 0 0 0 0 1 1
Gastric cancer 0 0 0 0 0 1 1
Hereditary motor and sensory neuropathy 0 0 1 0 0 0 1
Hereditary neuropathy or pain disorder 1 0 0 0 0 0 1
Lung cancer 0 0 0 0 0 1 1
Malignant lymphoma, large B-cell, diffuse 0 0 0 0 0 1 1
Melanoma 0 0 0 0 0 1 1
Nonpapillary renal cell carcinoma 0 0 0 0 0 1 1
Peripheral neuropathy 0 0 1 0 0 0 1
See cases 0 0 1 0 0 0 1
Squamous cell carcinoma of the head and neck 0 0 0 0 0 1 1
Squamous cell lung carcinoma 0 0 0 0 0 1 1
Thymoma 0 0 0 0 0 1 1
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 1 1
Uterine carcinosarcoma 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 54
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 38 11 1048 709 68 0 1874
Fulgent Genetics, Fulgent Genetics 1 3 320 61 6 0 391
Ambry Genetics 6 0 201 41 0 0 248
GeneDx 3 2 57 57 90 0 209
Illumina Laboratory Services, Illumina 0 0 79 16 102 0 197
Mayo Clinic Laboratories, Mayo Clinic 0 0 51 24 40 0 115
Breakthrough Genomics, Breakthrough Genomics 0 0 8 37 54 0 99
CeGaT Center for Human Genetics Tuebingen 0 0 40 45 1 0 86
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 21 21 16 0 58
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 1 0 25 31 0 0 57
PreventionGenetics, part of Exact Sciences 0 0 14 19 17 0 50
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 35 35
Clinical Genetics, Academic Medical Center 0 0 1 7 23 0 31
Athena Diagnostics 0 0 3 0 21 0 24
Eurofins Ntd Llc (ga) 0 0 12 2 6 0 20
Genome-Nilou Lab 0 0 0 0 18 0 18
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 16 1 0 0 17
Institute of Human Genetics, University Hospital Jena 16 0 0 0 0 0 16
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 1 0 1 0 14 0 16
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 0 7 6 0 13
OMIM 10 0 2 0 0 0 12
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 0 9 0 9
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 1 6 1 0 8
Baylor Genetics 0 1 6 0 0 0 7
Revvity Omics, Revvity 0 1 6 0 0 0 7
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 2 1 3 0 0 6
GeneReviews 0 0 0 0 0 5 5
Inherited Neuropathy Consortium 0 0 5 0 0 0 5
Laboratory of Genetics, Children's Clinical University Hospital Latvia 1 0 0 1 3 0 5
Gharavi Laboratory, Columbia University 0 0 4 0 0 0 4
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 3 3
Genomic Research Center, Shahid Beheshti University of Medical Sciences 1 0 2 0 0 0 3
Johns Hopkins Genomics, Johns Hopkins University 0 0 2 0 0 0 2
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 1 1 0 0 0 0 2
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 0 1 0 0 0 1
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 1 0 0 0 1
Clinical Laboratory Sciences Program (CLSP), King Saud bin Abdulaziz University for Health Sciences (KSAU-HS) 0 1 0 0 0 0 1
Department of Neurology, Hospital Garcia de Orta 1 0 0 0 0 0 1
Department of Pediatrics, GMC Srinagar, Government Medical College Srinagar 0 1 0 0 0 0 1
First Genomix Gene Laboratory, Genetic Diagnostics Department 0 1 0 0 0 0 1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 0 0 0 0 1 0 1
Kariminejad - Najmabadi Pathology & Genetics Center 1 0 0 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 1 0 0 0 1
MVZ Dr. Eberhard & Partner Dortmund 0 0 1 0 0 0 1
MVZ Martinsried, Medicover Genetics 0 0 1 0 0 0 1
MVZ Medizinische Genetik Mainz 0 0 1 0 0 0 1
Mendelics 1 0 0 0 0 0 1
Molecular Neuropsychiatry & Development Lab, Centre for Addiction and Mental Health 1 0 0 0 0 0 1
NHS Central & South Genomic Laboratory Hub 1 0 0 0 0 0 1
Neuberg Centre For Genomic Medicine, NCGM 0 0 1 0 0 0 1
OLLIN Analises Genomicas, OLLIN 1 0 0 0 0 0 1
Precision Medicine Center, Zhengzhou University 0 1 0 0 0 0 1
Solve-RD Consortium 0 1 0 0 0 0 1
Variantyx, Inc. 1 0 0 0 0 0 1

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