ClinVar Miner

Variants in gene TG

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
171 108 658 1213 179 47 2160

Condition and significance breakdown #

Total conditions: 35
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
not provided 140 47 105 1166 179 0 1563
Inborn genetic diseases 0 0 375 33 0 0 408
Iodotyrosyl coupling defect 31 10 227 26 26 0 315
not specified 0 0 52 37 18 0 105
Iodotyrosyl coupling defect; Autoimmune thyroid disease, susceptibility to, 3 13 46 16 1 0 0 76
TG-related disorder 11 7 14 29 7 0 68
Congenital hypothyroidism 10 5 5 2 1 1 24
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 19 19
Autoimmune thyroid disease, susceptibility to, 3 5 1 1 0 0 0 7
Acute myeloid leukemia 0 0 0 0 0 5 5
Ovarian serous cystadenocarcinoma 0 0 0 0 0 5 5
Cervical cancer 0 0 0 0 0 4 4
Familial papillary thyroid carcinoma with renal papillary neoplasia 0 0 4 0 0 0 4
Hepatocellular carcinoma 0 0 0 0 0 4 4
Lung cancer 0 0 0 0 0 4 4
Familial cancer of breast 0 0 0 0 0 3 3
Nonpapillary renal cell carcinoma 0 0 0 0 0 3 3
Thymoma 0 0 0 0 0 3 3
Uterine corpus endometrial carcinoma 0 0 0 0 0 3 3
Clear cell carcinoma of kidney 0 0 0 0 0 2 2
Colon adenocarcinoma 0 0 0 0 0 2 2
Gastric cancer 0 0 0 0 0 2 2
Malignant lymphoma, large B-cell, diffuse 0 0 0 0 0 2 2
Ovarian cancer 0 0 0 0 0 2 2
Sarcoma 0 0 0 0 0 2 2
Chronic lymphocytic leukemia/small lymphocytic lymphoma 0 0 0 0 0 1 1
Familial pancreatic carcinoma 0 0 0 0 0 1 1
Hereditary breast ovarian cancer syndrome 0 0 1 0 0 0 1
Hypothyroidism 0 1 0 0 0 0 1
Malignant tumor of esophagus 0 0 0 0 0 1 1
Malignant tumor of urinary bladder 0 0 0 0 0 1 1
Premature ovarian failure 0 0 1 0 0 0 1
Prostate cancer 0 0 1 0 0 0 1
See cases 0 0 1 0 0 0 1
Uterine carcinosarcoma 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 58
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 134 34 2 1119 123 0 1412
Ambry Genetics 0 0 375 33 0 0 408
Illumina Laboratory Services, Illumina 1 0 192 25 20 0 238
GeneDx 14 11 66 2 62 0 155
Breakthrough Genomics, Breakthrough Genomics 0 0 10 29 59 0 98
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 10 5 48 27 1 0 91
CeGaT Center for Human Genetics Tuebingen 2 2 25 42 5 0 76
Fulgent Genetics, Fulgent Genetics 13 46 16 1 0 0 76
PreventionGenetics, part of Exact Sciences 2 2 14 34 20 0 72
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 46 46
Revvity Omics, Revvity 2 1 23 0 0 0 26
Clinical Genetics, Academic Medical Center 1 0 2 8 9 0 20
OMIM 18 0 1 0 0 0 19
Genome-Nilou Lab 0 0 0 0 15 0 15
Baylor Genetics 3 0 10 0 0 0 13
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 1 2 8 2 0 13
Genetic Services Laboratory, University of Chicago 2 0 6 3 1 0 12
Polak associated Lab, IMAGINE Institute 6 4 0 1 1 0 12
Cambridge Genomics Laboratory, East Genomic Laboratory Hub, NHS Genomic Medicine Service 4 1 5 1 0 0 11
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 0 8 0 9
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 1 3 3 0 0 8
3billion 3 1 2 0 0 0 6
Department of Pathology and Laboratory Medicine, Sinai Health System 1 1 4 0 0 0 6
Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University, Chulalongkorn University 0 0 4 0 0 0 4
First Genomix Gene Laboratory, Genetic Diagnostics Department 1 3 0 0 0 0 4
Genetics and Molecular Pathology, SA Pathology 1 2 1 0 0 0 4
Dasa 3 0 0 0 0 0 3
Eurofins Ntd Llc (ga) 2 0 1 0 0 0 3
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 2 0 1 0 0 0 3
Mendelics 0 0 2 0 1 0 3
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 2 0 0 0 2
Department of Pediatrics, Division of Medical Genetics, Faculty of Medicine Ramathibodi Hospital, Mahidol University 1 1 0 0 0 0 2
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 1 1 0 0 0 0 2
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 2 0 0 0 2
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 0 0 1 1 0 0 2
Juno Genomics, Hangzhou Juno Genomics, Inc 2 0 0 0 0 0 2
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 1 0 1 0 0 0 2
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 0 1 0 0 0 0 1
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 0 1 0 0 0 1
Center for Precision Medicine, Vanderbilt University Medical Center 1 0 0 0 0 0 1
Centre of Medical Genetics, University Hospital Muenster 0 0 1 0 0 0 1
Clinical Biomedical Laboratory, Shriners Hospital For Children - Canada 0 1 0 0 0 0 1
Clinical Genomics Laboratory, Washington University in St. Louis 0 0 1 0 0 0 1
Daryl Scott Lab, Baylor College of Medicine 1 0 0 0 0 0 1
Division of Human Genetics, Children's Hospital of Philadelphia 1 0 0 0 0 0 1
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 0 1 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Institute of Human Genetics, University of Wuerzburg 0 1 0 0 0 0 1
Istanbul Faculty of Medicine, Istanbul University 0 0 1 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 1 0 0 0 1
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 1 0 0 0 1
Medical and Scientific Branch, Hong Kong Genome Institute 1 0 0 0 0 0 1
Molecular Oncology Research Center, Barretos Cancer Hospital 0 0 1 0 0 0 1
Pediatric Genetics Division, Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg 1 0 0 0 0 0 1
Science for Life laboratory, Karolinska Institutet 0 0 1 0 0 0 1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 0 1 0 0 0 1
Weiss Lab, University of Miami 1 0 0 0 0 0 1
Yale Center for Mendelian Genomics, Yale University 0 1 0 0 0 0 1

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