ClinVar Miner

Variants in gene TET2

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign other not provided total
166 33 1150 592 40 1 70 1976

Condition and significance breakdown #

Total conditions: 36
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Condition pathogenic likely pathogenic uncertain significance likely benign benign other not provided total
not specified 0 0 739 426 22 0 43 1211
not provided 142 17 449 256 38 0 0 886
TET2-related disorder 0 2 12 21 4 0 0 39
EBV-positive nodal T- and NK-cell lymphoma 19 0 0 0 0 0 0 19
Immunodeficiency 75 4 1 12 0 0 0 0 17
Acute myeloid leukemia 0 1 0 0 0 0 5 6
Cervical cancer 0 0 0 0 0 0 6 6
Colon adenocarcinoma 0 0 0 0 0 0 5 5
Myelodysplastic syndrome; Immunodeficiency 75 0 3 2 0 0 0 0 5
Neoplasm 0 4 1 0 0 0 0 5
Colorectal cancer 0 0 0 0 0 0 4 4
Myelodysplastic syndrome 1 1 2 0 0 0 0 4
Nonpapillary renal cell carcinoma 0 0 0 0 0 0 4 4
Ovarian serous cystadenocarcinoma 0 0 0 0 0 0 4 4
Angioimmunoblastic T-cell lymphoma 0 0 3 0 0 0 0 3
Familial cancer of breast 0 0 1 0 0 0 2 3
Thymoma 0 0 0 0 0 0 3 3
Atypical chronic myeloid leukemia, BCR-ABL1 negative 1 0 1 0 0 0 0 2
Chronic myeloid leukemia 0 0 2 0 0 0 0 2
Hepatocellular carcinoma 0 0 0 0 0 0 2 2
Lung cancer 0 0 0 0 0 0 2 2
Malignant tumor of esophagus 0 0 0 0 0 0 2 2
Multiple myeloma 0 2 0 0 0 0 0 2
Sarcoma 0 0 0 0 0 0 2 2
Uterine corpus endometrial carcinoma 0 0 0 0 0 0 2 2
Adrenocortical carcinoma, hereditary 0 0 0 0 0 0 1 1
Cholangiocarcinoma 0 0 0 0 0 0 1 1
Clonal hematopoiesis 1 0 0 0 0 0 0 1
IDH-wildtype glioblastoma 0 1 0 0 0 0 0 1
Malignant lymphoma, large B-cell, diffuse 0 0 0 0 0 0 1 1
Malignant tumor of urinary bladder 0 0 0 0 0 0 1 1
Nasopharyngeal carcinoma 0 1 0 0 0 0 0 1
Nephroblastoma 0 0 0 0 0 1 0 1
Squamous cell carcinoma 0 0 1 0 0 0 0 1
Third degree atrioventricular block 1 0 0 0 0 0 0 1
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 41
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign other not provided total
Ambry Genetics 0 0 725 419 0 0 0 1144
Labcorp Genetics (formerly Invitae), Labcorp 140 8 410 237 34 0 0 829
GeneDx 0 0 36 1 6 0 0 43
ITMI 0 0 0 0 0 0 43 43
CeGaT Center for Human Genetics Tuebingen 3 5 14 18 2 0 0 42
PreventionGenetics, part of Exact Sciences 0 2 12 21 4 0 0 39
Genetic Services Laboratory, University of Chicago 0 0 17 8 7 0 0 32
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 0 27 27
Mayo Clinic Laboratories, Mayo Clinic 0 1 6 3 17 0 0 27
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 1 4 8 13 0 0 26
Department of Clinical Pathology, School of Medicine, Fujita Health University 19 0 0 0 0 0 0 19
Breakthrough Genomics, Breakthrough Genomics 0 0 1 2 10 0 0 13
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 5 2 0 0 0 0 7
Baylor Genetics 0 0 5 0 0 0 0 5
Revvity Omics, Revvity 0 0 4 0 0 0 0 4
Unidad de Genómica Garrahan, Hospital de Pediatría Garrahan 0 0 0 0 4 0 0 4
Fulgent Genetics, Fulgent Genetics 0 2 1 0 0 0 0 3
Molecular Diagnostics Laboratory, University of Rochester Medical Center 0 0 3 0 0 0 0 3
Department of Pathology and Laboratory Medicine, Sinai Health System 0 1 1 0 0 0 0 2
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 0 2 0 0 0 0 0 2
Institute of Human Genetics, University of Leipzig Medical Center 2 0 0 0 0 0 0 2
Institute of Laboratory Medicine, Hospital Wels-Grieskirchen 1 0 1 0 0 0 0 2
Mendelics 1 0 1 0 0 0 0 2
New York Genome Center 0 0 2 0 0 0 0 2
OMIM 2 0 0 0 0 0 0 2
Oncology Lab, University of Education 0 0 2 0 0 0 0 2
Xiao lab, Department of Pathology, Memorial Sloan Kettering Cancer Center 0 2 0 0 0 0 0 2
AiLife Diagnostics, AiLife Diagnostics 0 0 1 0 0 0 0 1
Center for Human Genetics, University of Leuven 1 0 0 0 0 0 0 1
Centre for Clinical Genetics and Genomic Diagnostics, Zealand University Hospital 0 1 0 0 0 0 0 1
Department of Legal Medicine, University of Toyama 1 0 0 0 0 0 0 1
Diagnostic Genetics, Severance Hospital, Yonsei University College of Medicine 0 1 0 0 0 0 0 1
Donald Williams Parsons Laboratory, Baylor College of Medicine 0 0 0 0 0 1 0 1
Faculty of Pharmacy, Medical University of Gdansk 0 0 1 0 0 0 0 1
Institute of Human Genetics, University of Wuerzburg 0 0 1 0 0 0 0 1
Laboratory of Genetics, Children's Clinical University Hospital Latvia 0 0 0 1 0 0 0 1
Liquid Biopsy and Cancer Interception Group, Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research 0 0 1 0 0 0 0 1
Molecular Diagnostics Division, Virginia Commonwealth University 0 1 0 0 0 0 0 1
Molecular Genetics, Sadra Medical Genetics Laboratory 0 1 0 0 0 0 0 1
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 1 0 0 0 0 1
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 0 0 1 0 0 0 0 1

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