ClinVar Miner

Variants in gene RAD51C

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Minimum submission review status: Collection method:
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Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
284 235 1119 820 475 22 2198

Condition and significance breakdown #

Total conditions: 40
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Fanconi anemia complementation group O 179 66 835 438 18 0 1515
Hereditary cancer-predisposing syndrome 101 102 578 510 202 0 1301
Breast-ovarian cancer, familial, susceptibility to, 3 125 130 196 144 260 4 774
not provided 41 38 230 75 25 1 371
not specified 2 0 94 136 22 0 239
Breast-ovarian cancer, familial, susceptibility to, 3; Fanconi anemia complementation group O 17 16 87 22 1 3 143
Hereditary breast ovarian cancer syndrome 26 25 31 13 5 0 92
RAD51C-related disorder 11 1 19 13 2 0 46
Familial ovarian cancer 2 7 28 3 0 0 40
Breast and/or ovarian cancer 3 5 11 8 8 0 35
Malignant tumor of breast 2 0 8 3 4 0 17
Ovarian neoplasm 9 2 3 0 0 0 14
Gastric cancer 11 0 0 0 0 0 11
RAD51C-related cancer predisposition 9 2 0 0 0 0 11
Inherited ovarian cancer (without breast cancer) 2 5 1 0 0 0 8
Ovarian serous cystadenocarcinoma 0 0 0 0 0 6 6
Inherited breast cancer and ovarian cancer 2 1 1 1 0 0 5
Breast-ovarian cancer, familial, susceptibility to, 1 3 0 1 0 0 0 4
Hereditary cancer 0 1 0 3 0 0 4
Ovarian cancer 0 3 0 0 1 0 4
Uterine corpus endometrial carcinoma 0 0 0 0 0 4 4
Breast carcinoma 3 0 0 0 0 0 3
Familial cancer of breast 0 0 2 1 0 0 3
Carcinoma of colon 0 0 2 0 0 0 2
Hereditary site-specific ovarian cancer syndrome 2 0 0 0 0 0 2
Breast-ovarian cancer, familial, susceptibility to, 2 0 1 0 0 0 0 1
Childhood neoplasm 0 0 1 0 0 0 1
Diffuse midline glioma, H3 K27M-mutant 0 1 0 0 0 0 1
Endometrial carcinoma 1 0 0 0 0 0 1
Familial ovarian carcinoma 0 1 0 0 0 0 1
Glioma susceptibility 1 0 0 0 0 0 1 1
Hepatocellular carcinoma 0 0 0 0 0 1 1
Long QT syndrome 0 1 0 0 0 0 1
Microcephaly 0 0 1 0 0 0 1
Neoplasm 0 1 0 0 0 0 1
Premature ovarian failure 0 1 0 0 0 0 1
Premature ovarian insufficiency 0 0 1 0 0 0 1
Sarcoma 0 0 0 0 0 1 1
Thymoma 0 0 0 0 0 1 1
Uterine corpus cancer 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 112
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 178 57 823 428 16 0 1502
Ambry Genetics 90 91 360 399 196 0 1136
Myriad Genetics, Inc. 92 96 12 123 257 0 580
Color Diagnostics, LLC DBA Color Health 41 26 301 181 8 0 557
GeneDx 22 29 181 91 31 0 354
Baylor Genetics 26 39 140 0 0 0 205
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 23 11 76 24 8 0 142
Quest Diagnostics Nichols Institute San Juan Capistrano 12 5 81 18 7 0 123
Fulgent Genetics, Fulgent Genetics 11 11 73 12 0 0 107
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 7 3 25 44 7 0 86
Department of Pathology and Laboratory Medicine, Sinai Health System 13 8 42 17 6 0 86
Sema4, Sema4 8 2 44 17 4 0 75
Counsyl 9 6 27 13 5 0 59
PreventionGenetics, part of Exact Sciences 8 2 23 21 5 0 59
Leiden Open Variation Database 18 3 17 11 0 0 49
Mendelics 2 7 21 13 3 0 46
CeGaT Center for Human Genetics Tuebingen 7 5 4 25 2 0 43
Hereditary Cancer Group, L’Institut d'Investigació Biomèdica de Bellvitge 11 9 17 3 0 0 40
Molecular Pathology, Peter Maccallum Cancer Centre 2 7 28 3 0 0 40
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario 1 4 11 8 8 0 32
German Consortium for Hereditary Breast and Ovarian Cancer, University Hospital Cologne 6 14 6 3 1 0 30
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 1 15 0 9 0 25
Institute for Biomarker Research, Medical Diagnostic Laboratories, L.L.C. 2 2 7 12 1 0 24
Genetic Services Laboratory, University of Chicago 1 1 10 4 4 0 20
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 3 1 10 4 0 0 18
Institute of Human Genetics, University of Leipzig Medical Center 9 3 5 1 0 0 18
Molecular Diagnostics Laboratory, Catalan Institute of Oncology 1 4 7 4 1 0 17
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 14 14
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 2 1 1 5 5 0 14
University of Washington Department of Laboratory Medicine, University of Washington 0 1 1 11 0 0 13
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 1 0 1 2 8 0 12
Breakthrough Genomics, Breakthrough Genomics 0 0 1 6 5 0 12
Illumina Laboratory Services, Illumina 1 0 8 3 2 0 12
Clinical Genetics Laboratory, Department of Pathology, Netherlands Cancer Institute 1 0 1 5 4 0 11
Laboratory for Genotyping Development, RIKEN 11 0 0 0 0 0 11
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 2 0 8 0 0 0 10
Mayo Clinic Laboratories, Mayo Clinic 0 0 3 5 1 0 9
Revvity Omics, Revvity 5 3 1 0 0 0 9
BRCAlab, Lund University 8 0 0 0 0 0 8
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 1 4 3 0 0 0 8
GeneKor MSA 1 1 3 1 2 0 8
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 5 3 0 0 0 0 8
OMIM 8 0 0 0 0 0 8
True Health Diagnostics 0 0 2 5 0 0 7
Genesis Genomics 5 1 0 0 0 0 6
Genetics and Molecular Pathology, SA Pathology 1 0 4 1 0 0 6
Genomics and Molecular Medicine Service, East Genomic Laboratory Hub, NHS Genomic Medicine Service 0 4 2 0 0 0 6
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 1 5 0 0 0 0 6
MGZ Medical Genetics Center 2 2 2 0 0 0 6
Cambridge Genomics Laboratory, East Genomic Laboratory Hub, NHS Genomic Medicine Service 1 2 1 1 0 0 5
Cancer Genomics Group, Japanese Foundation For Cancer Research 0 1 4 0 0 0 5
Centre for Mendelian Genomics, University Medical Centre Ljubljana 4 0 1 0 0 0 5
Department of Molecular Diagnostics, Institute of Oncology Ljubljana 2 1 2 0 0 0 5
Genetics Laboratory, Great Ormond Street Hospital NHS Foundation Trust, North Thames Genomic Laboratory Hub 2 3 0 0 0 0 5
Neuberg Centre For Genomic Medicine, NCGM 0 0 5 0 0 0 5
CZECANCA consortium 2 2 0 0 0 0 4
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 3 1 0 4
Eurofins Ntd Llc (ga) 0 0 2 0 2 0 4
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 1 3 0 4
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 4 4
GenomeConnect, ClinGen 0 0 0 0 0 4 4
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 1 2 1 0 0 0 4
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 4 0 0 4
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 3 0 0 1 0 4
Clinical Genetics Laboratory, Skane University Hospital Lund 3 0 0 0 0 0 3
Department of Human Genetics, Hannover Medical School 2 1 0 0 0 0 3
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 2 0 0 1 0 0 3
Division of Medical Genetics, University of Washington 0 1 2 0 0 0 3
Juno Genomics, Hangzhou Juno Genomics, Inc 2 1 0 0 0 0 3
Medical Genetics Laboratory, Umraniye Training and Research Hospital, University of Health Sciences 3 0 0 0 0 0 3
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 3 0 0 0 0 0 3
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 3 0 0 0 0 0 3
ARUP Laboratories, Cytogenetics and Genomic Microarray, ARUP Laboratories 2 0 0 0 0 0 2
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 2 0 0 0 2
Daryl Scott Lab, Baylor College of Medicine 0 0 2 0 0 0 2
Dasa 1 0 0 1 0 0 2
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 0 1 1 0 0 0 2
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 0 0 0 2 0 2
Hereditary Cancer Laboratory, Hospital Universitario 12 de Octubre 0 0 1 1 0 0 2
Institute of Human Genetics, FAU Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg 1 1 0 0 0 0 2
Institute of Immunology and Genetics Kaiserslautern 1 0 1 0 0 0 2
King Laboratory, University of Washington 2 0 0 0 0 0 2
Laboratoire de Biologie et Génétique du Cancer, Centre François Baclesse 2 0 0 0 0 0 2
Laboratorio de I+D, Fundación Centro Médico de Asturias 0 0 0 0 2 0 2
Liquid Biopsy and Cancer Interception Group, Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research 2 0 0 0 0 0 2
Medical and Scientific Branch, Hong Kong Genome Institute 2 0 0 0 0 0 2
Praxis Für Humangenetik, Biosciencia MVZ Labor Saar 1 0 1 0 0 0 2
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 0 1 0 0 1
Clinical Genetics and Genomics, Karolinska University Hospital 1 0 0 0 0 0 1
Department of Genomics, ADN Uruguay 1 0 0 0 0 0 1
Department of Pediatrics, Samsung Medical Center, Samsung Medical Center 0 0 1 0 0 0 1
Dipartimento Di Medicina Di Precisione, Università Degli Studi Della Campania Luigi Vanvitelli 0 1 0 0 0 0 1
Division of Human Genetics, Children's Hospital of Philadelphia 1 0 0 0 0 0 1
EVOGEN 0 1 0 0 0 0 1
Genetics and Personalized Medicine Clinic, Tartu University Hospital 0 1 0 0 0 0 1
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 0 0 1 0 1
Genome-Nilou Lab 0 0 0 0 1 0 1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 0 0 0 0 1 0 1
Genomics Laboratory, Virgen de la Arrixaca University Clinical Hospital 0 0 1 0 0 0 1
Human Genetics Bochum, Ruhr University Bochum 0 1 0 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 1 0 0 0 1
Laboratory of Genetics, Children's Clinical University Hospital Latvia 1 0 0 0 0 0 1
Lifecell International Pvt. Ltd 0 1 0 0 0 0 1
MVZ Praenatalmedizin und Genetik Nuernberg 0 0 0 1 0 0 1
Medical Cytogenetics and Molecular Genetics Laboratory, IRCCS Istituto Auxologico Italiano 0 1 0 0 0 0 1
Molecular Oncology Research Center, Barretos Cancer Hospital 1 0 0 0 0 0 1
NHS Central & South Genomic Laboratory Hub 1 0 0 0 0 0 1
OLLIN Analises Genomicas, OLLIN 0 0 1 0 0 0 1
Reproductive Development, Murdoch Childrens Research Institute 0 0 1 0 0 0 1
Swisher Lab, University of Washington 0 1 0 0 0 0 1
UNC Molecular Genetics Laboratory, University of North Carolina at Chapel Hill 1 0 0 0 0 0 1
Variantyx, Inc. 0 1 0 0 0 0 1

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