ClinVar Miner

Variants in gene MYO15A

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
507 385 1376 1896 232 34 3843

Condition and significance breakdown #

Total conditions: 40
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
not provided 300 113 677 1841 228 0 2908
Autosomal recessive nonsyndromic hearing loss 3 258 267 384 23 43 5 896
Inborn genetic diseases 7 1 543 32 0 0 583
not specified 0 2 168 159 81 0 388
MYO15A-related disorder 6 10 17 56 8 0 97
Rare genetic deafness 27 20 2 0 0 0 49
Hearing impairment 8 9 10 0 0 0 27
Nonsyndromic genetic hearing loss 5 4 0 6 2 0 17
Monogenic hearing loss 6 3 4 0 0 0 13
Hearing loss, autosomal recessive 3 9 0 0 0 0 12
Childhood onset hearing loss 0 1 5 0 0 0 6
Ear malformation 2 4 0 0 0 0 6
Ovarian serous cystadenocarcinoma 0 0 0 0 0 6 6
Gastric cancer 0 0 0 0 0 4 4
Congenital sensorineural hearing impairment 1 1 1 0 0 0 3
Uterine carcinosarcoma 0 0 0 0 0 3 3
Acute myeloid leukemia 0 0 0 0 0 2 2
Hepatocellular carcinoma 0 0 0 0 0 2 2
Intellectual disability 2 0 0 0 0 0 2
Lung cancer 0 0 0 0 0 2 2
Papillary renal cell carcinoma type 1 0 0 0 0 0 2 2
Thymoma 0 0 0 0 0 2 2
Alport syndrome 0 0 1 0 0 0 1
Autosomal recessive nonsyndromic hearing loss 9 0 1 0 0 0 0 1
Carney complex, type 1 1 0 0 0 0 0 1
Cervical cancer 0 0 0 0 0 1 1
Cholangiocarcinoma 0 0 0 0 0 1 1
Congenital portosystemic shunt 0 0 1 0 0 0 1
Deafness, with smith-magenis syndrome 1 0 0 0 0 0 1
Familial cancer of breast 0 0 0 0 0 1 1
Malignant lymphoma, large B-cell, diffuse 0 0 0 0 0 1 1
Malignant tumor of esophagus 0 0 0 0 0 1 1
Melanoma 0 0 0 0 0 1 1
Mesothelioma 0 0 0 0 0 1 1
Nonsyndromic genetic hearing loss; Rare genetic deafness 1 0 0 0 0 0 1
Sarcoma 0 0 0 0 0 1 1
Sensorineural hearing loss disorder 1 0 0 0 0 0 1
Squamous cell lung carcinoma 0 0 0 0 0 1 1
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 1 1
Uterine corpus endometrial carcinoma 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 115
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 273 56 244 1725 154 0 2452
GeneDx 53 47 409 158 131 0 798
Ambry Genetics 7 1 543 32 0 0 583
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 28 21 117 113 69 0 348
Illumina Laboratory Services, Illumina 3 3 244 11 24 0 285
CeGaT Center for Human Genetics Tuebingen 15 8 50 74 5 0 152
Institute of Rare Diseases, West China Hospital, Sichuan University 60 91 0 0 0 0 151
PreventionGenetics, part of Exact Sciences 6 10 17 63 33 0 129
Breakthrough Genomics, Breakthrough Genomics 1 0 9 37 71 0 118
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 25 11 49 21 12 0 118
Molecular Diagnosis Center for Deafness 53 21 28 0 1 0 103
Eurofins Ntd Llc (ga) 6 1 52 8 19 0 86
Fulgent Genetics, Fulgent Genetics 14 48 23 0 1 0 86
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 3 23 6 19 0 51
Mayo Clinic Laboratories, Mayo Clinic 0 3 7 2 27 0 39
Department of Pathology and Laboratory Medicine, Sinai Health System 1 4 24 2 0 0 31
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 29 29
Athena Diagnostics 1 1 12 6 8 0 28
Deafness Molecular Diagnostic Center, Chinese PLA General Hospital 12 6 8 0 0 0 26
3billion 7 7 11 0 0 0 25
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, Iran University of Medical Sciences 19 6 0 0 0 0 25
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 4 2 3 1 15 0 25
Juno Genomics, Hangzhou Juno Genomics, Inc 6 9 8 0 0 0 23
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 9 12 1 0 0 0 22
Revvity Omics, Revvity 4 3 12 1 0 0 20
Department of Otolaryngology – Head & Neck Surgery, Cochlear Implant Center 3 5 11 0 0 0 19
Laboratory of Prof. Karen Avraham, Tel Aviv University 18 1 0 0 0 0 19
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 5 2 4 2 5 0 18
Genome-Nilou Lab 0 0 0 0 18 0 18
National Institute on Deafness and Communication Disorders, National Institutes of Health 9 2 6 0 0 0 17
ClinGen Hearing Loss Variant Curation Expert Panel 5 4 0 5 2 0 16
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 0 15 0 15
Baylor Genetics 0 0 13 0 0 0 13
Genetic Testing Center for Deafness, Department of Otolaryngology Head & Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital 5 6 2 0 0 0 13
Genetics Laboratory, Great Ormond Street Hospital NHS Foundation Trust, North Thames Genomic Laboratory Hub 6 3 4 0 0 0 13
Genetics Research Center, University of Social Welfare and Rehabilitation Sciences 6 6 1 0 0 0 13
OMIM 13 0 0 0 0 0 13
Center for Statistical Genetics, Columbia University 10 2 0 0 0 0 12
Division of Human Genetics, Children's Hospital of Philadelphia 4 1 5 0 0 1 11
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 1 6 3 0 0 11
Neuberg Centre For Genomic Medicine, NCGM 0 3 7 0 0 0 10
Cambridge Genomics Laboratory, East Genomic Laboratory Hub, NHS Genomic Medicine Service 7 2 0 0 0 0 9
WangQJ Lab, Chinese People's Liberation Army General Hospital 1 2 6 0 0 0 9
Hereditary Deafness Genetic Testing Group, The First Affiliated Hospital of Zhengzhou University 0 8 0 0 0 0 8
Laboratory of Genetics, Children's Clinical University Hospital Latvia 2 0 0 2 4 0 8
Variantyx, Inc. 4 4 0 0 0 0 8
Wonkam Laboratory, Johns Hopkins University 5 1 1 1 0 0 8
Institute of Human Genetics, University of Leipzig Medical Center 3 2 1 1 0 0 7
Clinical Genetics Laboratory, Skane University Hospital Lund 1 3 2 0 0 0 6
First Genomix Gene Laboratory, Genetic Diagnostics Department 4 2 0 0 0 0 6
Kariminejad - Najmabadi Pathology & Genetics Center 2 4 0 0 0 0 6
King Laboratory, University of Washington 3 3 0 0 0 0 6
MVZ Martinsried, Medicover Genetics 4 1 1 0 0 0 6
Mendelics 2 0 2 2 0 0 6
University of Washington Center for Mendelian Genomics, University of Washington 0 6 0 0 0 0 6
Daryl Scott Lab, Baylor College of Medicine 0 0 5 0 0 0 5
Human Genetics Bochum, Ruhr University Bochum 1 4 0 0 0 0 5
Centre for Mendelian Genomics, University Medical Centre Ljubljana 1 2 1 0 0 0 4
GenomeConnect, ClinGen 0 0 0 0 0 4 4
Hereditary Research Laboratory, Bethlehem University 4 0 0 0 0 0 4
Bioscientia Institut fuer Medizinische Diagnostik GmbH, Sonic Healthcare 2 0 1 0 0 0 3
Department of Human Genetics, Hannover Medical School 0 3 0 0 0 0 3
Dubai Health Genomic Medicine Center, Dubai Health 0 0 3 0 0 0 3
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 1 0 2 0 0 0 3
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 1 1 0 1 0 3
Laboratory of Human Genetics, Universidade de São Paulo 2 1 0 0 0 0 3
Laboratory of Molecular Genetics, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine 3 0 0 0 0 0 3
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 0 1 1 0 0 0 2
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 0 2 0 0 2
Clinical Genetics Laboratory, University Hospital Schleswig-Holstein 2 0 0 0 0 0 2
Dasa 2 0 0 0 0 0 2
Department of Genetics, Sultan Qaboos University Hospital 2 0 0 0 0 0 2
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 1 0 1 0 0 0 2
Genetic Services Laboratory, University of Chicago 1 1 0 0 0 0 2
Genetics Laboratory, Department of Biology, Semnan University 2 0 0 0 0 0 2
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 0 0 2 0 0 0 2
Hereditary Hearing Loss Research Unit, University of Madras 1 1 0 0 0 0 2
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 2 0 0 0 2
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 1 1 0 0 0 2
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 1 1 0 0 0 2
Laboratory of Genetic Epidemiology, Research Centre for Medical Genetics 0 2 0 0 0 0 2
Laboratory of Molecular, Cellular and Translation Genetics in Otolaryngology/ Lim32-hcfmusp, University of Sao Paulo School of Medicine Clinics Hospital 2 0 0 0 0 0 2
MVZ Medizinische Genetik Mainz 1 0 1 0 0 0 2
Neurogenetic Laboratory, Second Faculty of Medicine, Charles University 0 1 1 0 0 0 2
Pittsburgh Clinical Genomics Laboratory, University of Pittsburgh Medical Center 0 1 1 0 0 0 2
Shenzhen Maternity and Child Healthcare Hospital, Institute of Maternal and Child Medicine Research 2 0 0 0 0 0 2
The Shared Resource Centre "Genome", Research Centre for Medical Genetics 1 1 0 0 0 0 2
Yale Center for Mendelian Genomics, Yale University 0 2 0 0 0 0 2
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 0 1 1 0 0 0 2
Center for Personalized Medicine, Children's Hospital Los Angeles 0 0 1 0 0 0 1
Center of Genomic medicine, Geneva, University Hospital of Geneva 1 0 0 0 0 0 1
Clinical Genetics and Genomics, Karolinska University Hospital 0 1 0 0 0 0 1
Clinical Genomics, G42 Labs 1 0 0 0 0 0 1
Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences 0 0 1 0 0 0 1
Department of Pediatrics, Division of Medical Genetics, Faculty of Medicine Ramathibodi Hospital, Mahidol University 0 1 0 0 0 0 1
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University 0 0 1 0 0 0 1
Dr.Nikuei Genetic Center 1 0 0 0 0 0 1
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 0 1 0 0 0 0 1
Genetics and Genomic Medicine Centre, NeuroGen Healthcare, NeuroGen Healthcare 0 1 0 0 0 0 1
Institute of Human Genetics, University of Goettingen 0 1 0 0 0 0 1
Institute of Human Genetics, University of Wuerzburg 0 0 1 0 0 0 1
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 1 0 0 0 0 0 1
Intergen Genetics and Rare Diseases Diagnosis Center 1 0 0 0 0 0 1
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 1 0 0 1
Laboratory of Dr. Barbara Vona, University Medical Center Göttingen 1 0 0 0 0 0 1
Laboratory of Molecular Genetics, National Institutes of Health 0 1 0 0 0 0 1
Lifecell International Pvt. Ltd 0 1 0 0 0 0 1
Medical Molecular Genetics Department, National Research Center 0 1 0 0 0 0 1
Medical and Scientific Branch, Hong Kong Genome Institute 1 0 0 0 0 0 1
Molecular Genetics Laboratory, BC Children's and BC Women's Hospitals 0 1 0 0 0 0 1
Molecular Genetics, Royal Melbourne Hospital 0 0 0 1 0 0 1
Payam Genetics Center, General Welfare Department of North Khorasan Province 1 0 0 0 0 0 1
Santos-Cortez Lab, University of Colorado School of Medicine 0 1 0 0 0 0 1
The Genetic Institute, Ha'emek Medical Center 1 0 0 0 0 0 1
UAEU Genomics Laboratory, United Arab Emirates University 0 1 0 0 0 0 1

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