ClinVar Miner

Variants in gene MSH3

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
474 228 2671 1547 101 45 4721

Condition and significance breakdown #

Total conditions: 30
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
not provided 310 105 2069 1248 96 0 3739
Hereditary cancer-predisposing syndrome 224 55 1750 706 11 0 2710
Endometrial carcinoma 7 98 331 3 0 0 439
Familial adenomatous polyposis 4 237 68 73 25 2 9 402
not specified 2 0 85 137 19 0 230
Endometrial carcinoma; Familial adenomatous polyposis 4 4 9 76 9 1 0 98
MSH3-related disorder 3 3 49 39 2 0 96
Ovarian serous cystadenocarcinoma 0 0 0 0 0 6 6
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 6 6
Diffuse midline glioma, H3 K27-altered 0 0 3 0 0 0 3
Gastric cancer 0 0 0 0 0 3 3
Nonpapillary renal cell carcinoma 0 0 0 0 0 3 3
Cervical cancer 0 0 0 0 0 2 2
Clear cell carcinoma of kidney 0 0 0 0 0 2 2
Familial cancer of breast 0 0 0 0 0 2 2
Hepatocellular carcinoma 0 0 0 0 0 2 2
Lung cancer 0 0 0 0 0 2 2
Malignant tumor of esophagus 0 0 0 0 0 2 2
Neoplasm 0 2 0 0 0 0 2
Ovarian cancer 0 0 0 0 0 2 2
Familial prostate cancer 0 0 0 0 0 1 1
Hereditary cancer 0 0 0 1 0 0 1
Lymphoma 0 0 0 0 0 1 1
Malignant tumor of urinary bladder 0 0 0 0 0 1 1
Papillary renal cell carcinoma type 1 0 0 0 0 0 1 1
Sarcoma 0 0 0 0 0 1 1
Squamous cell carcinoma of the head and neck 0 0 0 0 0 1 1
Thymoma 0 0 0 0 0 1 1
Uterine carcinosarcoma 0 0 0 0 0 1 1
Uterine corpus endometrial carcinoma 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 50
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 309 70 1996 1227 36 0 3638
Ambry Genetics 224 50 1706 704 5 0 2689
Baylor Genetics 7 98 330 0 0 0 435
Myriad Genetics, Inc. 233 58 0 2 0 0 293
GeneDx 2 13 191 6 65 0 277
Quest Diagnostics Nichols Institute San Juan Capistrano 2 16 182 40 15 0 255
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 1 9 79 132 4 0 225
Sema4, Sema4 0 8 125 38 3 0 174
Department of Pathology and Laboratory Medicine, Sinai Health System 5 2 62 35 3 0 107
PreventionGenetics, part of Exact Sciences 3 3 49 39 2 0 96
Fulgent Genetics, Fulgent Genetics 2 9 48 2 0 0 61
CeGaT Center for Human Genetics Tuebingen 6 4 7 34 1 0 52
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 1 3 34 0 0 0 38
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 36 36
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 1 1 9 9 7 0 27
Mayo Clinic Laboratories, Mayo Clinic 0 0 8 5 5 0 18
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 2 0 13 1 0 0 16
Breakthrough Genomics, Breakthrough Genomics 0 0 7 7 0 0 14
Genetic Services Laboratory, University of Chicago 0 2 5 4 2 0 13
GeneKor MSA 0 0 0 0 9 0 9
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 8 8
Dasa 1 1 1 2 1 0 6
Mendelics 0 1 3 1 0 0 5
MGZ Medical Genetics Center 1 1 2 0 0 0 4
OMIM 4 0 0 0 0 0 4
Revvity Omics, Revvity 0 1 3 0 0 0 4
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 1 1 1 0 0 3
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 3 0 0 0 3
Laboratory of Medical Genetics Unit, Bambino Gesù Children's Hospital 0 0 3 0 0 0 3
ARUP Laboratories, Cytogenetics and Genomic Microarray, ARUP Laboratories 2 0 0 0 0 0 2
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 2 0 0 2
Department of Human Genetics, Hannover Medical School 0 0 2 0 0 0 2
Laboratory of Genetics, Children's Clinical University Hospital Latvia 0 0 0 2 0 0 2
OLLIN Analises Genomicas, OLLIN 0 1 1 0 0 0 2
Bionano Laboratories 0 0 1 0 0 0 1
CENTOGENE GmbH and LLC - Guiding Precision Medicine 1 0 0 0 0 0 1
Clinical Genetics Laboratory, Department of Pathology, Netherlands Cancer Institute 0 0 0 1 0 0 1
Clinical Genetics, Academic Medical Center 0 0 0 1 0 0 1
Department of Pediatrics, Memorial Sloan Kettering Cancer Center 0 1 0 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 0 1 0 0 0 0 1
First Genomix Gene Laboratory, Genetic Diagnostics Department 0 1 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Helix 0 0 1 0 0 0 1
Institute for Biomarker Research, Medical Diagnostic Laboratories, L.L.C. 0 0 0 0 1 0 1
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 0 0 1 0 0 0 1
Johns Hopkins Genomics, Johns Hopkins University 0 0 1 0 0 0 1
Juno Genomics, Hangzhou Juno Genomics, Inc 0 1 0 0 0 0 1
Neuberg Centre For Genomic Medicine, NCGM 0 0 1 0 0 0 1
Oncological Genetic Counseling Clinic, "Carlo Poma" Hospital 0 0 1 0 0 0 1
Praxis Für Humangenetik, Biosciencia MVZ Labor Saar 1 0 0 0 0 0 1

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