ClinVar Miner

Variants in gene MRE11

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Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
127 138 1427 798 110 1 23 55 2459

Condition and significance breakdown #

Total conditions: 37
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Condition pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
Hereditary cancer-predisposing syndrome 71 43 1167 498 15 0 0 0 1775
Ataxia-telangiectasia-like disorder 72 32 525 419 26 0 0 1 1074
Ataxia-telangiectasia-like disorder 1 21 89 239 21 35 0 0 1 378
not provided 14 15 156 80 70 0 0 18 332
not specified 0 0 47 26 31 0 0 0 95
Hereditary breast ovarian cancer syndrome 2 5 15 21 11 0 0 0 54
MRE11-related disorder 1 1 15 12 4 0 0 0 33
Malignant tumor of urinary bladder 0 0 0 0 0 0 23 3 26
Ovarian serous cystadenocarcinoma 0 0 0 0 0 0 0 9 9
Ovarian cancer 0 1 0 0 4 0 0 0 5
Uterine corpus endometrial carcinoma 0 0 0 0 0 0 0 5 5
Acute myeloid leukemia 0 0 0 0 0 0 0 4 4
Cervical cancer 0 0 0 0 0 0 0 4 4
Malignant tumor of esophagus 0 0 0 0 0 0 0 4 4
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 0 0 3 3
Breast carcinoma 1 1 0 0 0 0 0 0 2
Dystonic disorder; Depression; Parkinsonian disorder; Dementia 0 0 2 0 0 0 0 0 2
Familial cancer of breast 0 0 0 0 0 0 0 2 2
Gastric cancer 0 0 0 0 0 0 0 2 2
Hepatocellular carcinoma 0 0 0 0 0 0 0 2 2
Lung cancer 0 0 0 0 0 0 0 2 2
See cases 0 0 2 0 0 0 0 0 2
Thymoma 0 0 0 0 0 0 0 2 2
Uterine carcinosarcoma 0 0 0 0 0 0 0 2 2
Colon adenocarcinoma 0 0 0 0 0 0 0 1 1
Colonic neoplasm 1 0 0 0 0 0 0 0 1
Eccrine porocarcinoma 0 0 1 0 0 0 0 0 1
Hereditary cancer 0 0 0 1 0 0 0 0 1
Lymphoma 0 0 0 0 0 0 0 1 1
Malignant lymphoma, large B-cell, diffuse 0 0 0 0 0 0 0 1 1
Neoplasm 0 1 0 0 0 0 0 0 1
Ovarian neoplasm 0 0 1 0 0 0 0 0 1
Premature ovarian insufficiency 0 0 1 0 0 0 0 0 1
Renal transitional cell carcinoma 1 0 0 0 0 0 0 0 1
Sarcoma 0 0 0 0 0 0 0 1 1
Squamous cell lung carcinoma 0 0 0 0 0 0 0 1 1
Triple-negative breast cancer 0 0 0 0 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 73
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign association other not provided total
Ambry Genetics 69 43 1148 484 8 0 0 0 1752
Labcorp Genetics (formerly Invitae), Labcorp 72 32 530 421 26 0 0 0 1079
Baylor Genetics 7 66 103 0 0 0 0 0 176
GeneDx 7 3 43 42 64 0 0 0 159
Illumina Laboratory Services, Illumina 0 1 95 7 18 0 0 0 121
Quest Diagnostics Nichols Institute San Juan Capistrano 1 3 80 9 14 0 0 0 107
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 3 3 43 14 26 0 0 0 89
Athena Diagnostics 2 4 47 15 16 0 0 0 84
Fulgent Genetics, Fulgent Genetics 1 14 51 0 0 0 0 0 66
CeGaT Center for Human Genetics Tuebingen 9 5 6 25 4 0 0 0 49
Sema4, Sema4 0 0 24 19 5 0 0 0 48
PreventionGenetics, part of Exact Sciences 1 1 15 12 10 0 0 0 39
Breakthrough Genomics, Breakthrough Genomics 0 0 2 9 26 0 0 0 37
Dr. Peter K. Rogan Lab, Western University 0 1 0 0 0 0 0 35 36
National Health Laboratory Service, Universitas Academic Hospital and University of the Free State 0 0 3 21 11 0 0 0 35
Revvity Omics, Revvity 8 5 21 0 0 0 0 0 34
Counsyl 1 2 6 9 9 0 0 0 27
Gray Institute for Radiation Oncology & Biology, University of Oxford 0 0 0 0 0 0 23 0 23
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 9 6 6 0 0 0 21
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 1 19 0 0 0 20
Harris Lab, University of Minnesota 0 0 0 0 0 0 0 18 18
GeneKor MSA 0 0 13 0 4 0 0 0 17
Cancer Genomics Group, Japanese Foundation For Cancer Research 1 1 10 0 0 0 0 0 12
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 2 6 3 0 0 0 11
Mayo Clinic Laboratories, Mayo Clinic 0 0 4 0 7 0 0 0 11
University of Washington Department of Laboratory Medicine, University of Washington 0 0 3 8 0 0 0 0 11
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 1 9 0 0 0 0 0 10
Eurofins Ntd Llc (ga) 1 0 1 3 4 0 0 0 9
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 0 7 1 0 0 0 8
Department of Pathology and Laboratory Medicine, Sinai Health System 1 1 4 0 0 0 0 0 6
OMIM 6 0 0 0 0 0 0 0 6
Genesis Genomics 2 3 0 0 0 0 0 0 5
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 1 1 3 0 0 0 5
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 1 0 0 4 0 0 0 5
Institute of Human Genetics Munich, TUM University Hospital 1 3 0 0 0 0 0 0 4
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 1 3 0 0 0 0 4
Medical Genetics Laboratory, Umraniye Training and Research Hospital, University of Health Sciences 3 1 0 0 0 0 0 0 4
Mendelics 2 1 0 1 0 0 0 0 4
Neuberg Centre For Genomic Medicine, NCGM 1 0 3 0 0 0 0 0 4
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 3 0 0 0 0 0 3
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 3 0 0 0 0 0 3
Genetic Services Laboratory, University of Chicago 0 0 0 3 0 0 0 0 3
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 1 0 1 0 0 0 0 0 2
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 1 1 0 0 0 0 0 2
Dasa 1 0 1 0 0 0 0 0 2
First Genomix Gene Laboratory, Genetic Diagnostics Department 2 0 0 0 0 0 0 0 2
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 2 0 0 0 0 0 2
New York Genome Center 1 1 0 0 0 0 0 0 2
Undiagnosed Diseases Network, NIH 1 1 0 0 0 0 0 0 2
Variantyx, Inc. 0 2 0 0 0 0 0 0 2
3billion 1 0 0 0 0 0 0 0 1
Anatomical Molecular Laboratory, Singapore General Hospital 0 0 1 0 0 0 0 0 1
Department of Genomics, ADN Uruguay 0 1 0 0 0 0 0 0 1
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 0 0 0 0 0 1
Dubai Health Genomic Medicine Center, Dubai Health 0 0 1 0 0 0 0 0 1
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 1 0 0 0 0 0 0 0 1
Genetics and Genomic Medicine Centre, NeuroGen Healthcare, NeuroGen Healthcare 0 1 0 0 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 0 1 1
GenomeConnect, ClinGen 0 0 0 0 0 0 0 1 1
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 0 0 0 0 0 0 0 1
German Consortium for Hereditary Breast and Ovarian Cancer, University Hospital Cologne 0 0 1 0 0 0 0 0 1
Human Genome Lab, NIMHANS, National Institute of Mental Health and Neuro Sciences 0 1 0 0 0 0 0 0 1
Institute of Human Genetics, University Hospital of Duesseldorf 0 1 0 0 0 0 0 0 1
Juno Genomics, Hangzhou Juno Genomics, Inc 0 0 1 0 0 0 0 0 1
Laboratorio de I+D, Fundación Centro Médico de Asturias 0 0 0 1 0 0 0 0 1
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 0 0 1 0 0 0 1
Lifecell International Pvt. Ltd 1 0 0 0 0 0 0 0 1
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 0 1 0 0 0 0 0 0 1
Molecular Oncology Laboratory, Centre Jean Perrin 0 0 0 0 0 1 0 0 1
Molecular Oncology Research Center, Barretos Cancer Hospital 0 0 1 0 0 0 0 0 1
Praxis Für Humangenetik, Biosciencia MVZ Labor Saar 0 0 1 0 0 0 0 0 1
Reproductive Development, Murdoch Childrens Research Institute 0 0 1 0 0 0 0 0 1
UCLA Clinical Genomics Center, UCLA 0 1 0 0 0 0 0 0 1

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