ClinVar Miner

Variants in gene LAMA4

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Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
1 3 1308 840 212 40 2184

Condition and significance breakdown #

Total conditions: 40
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Dilated cardiomyopathy 1JJ 1 2 836 493 88 1 1386
Cardiovascular phenotype 0 0 731 406 10 0 1147
not provided 0 1 273 167 106 1 537
not specified 0 0 76 138 91 3 262
Cardiomyopathy 0 0 28 20 22 0 68
LAMA4-related disorder 0 0 19 31 4 0 54
Primary dilated cardiomyopathy 0 0 7 1 0 0 8
Ovarian serous cystadenocarcinoma 0 0 0 0 0 7 7
Primary familial hypertrophic cardiomyopathy 0 0 7 0 0 0 7
Cervical cancer 0 0 0 0 0 5 5
Lung cancer 0 0 0 0 0 4 4
Melanoma 0 0 0 0 0 4 4
Arrhythmogenic right ventricular cardiomyopathy 0 0 3 0 0 0 3
Nonpapillary renal cell carcinoma 0 0 0 0 0 3 3
Familial cancer of breast 0 0 0 0 0 2 2
Gastric cancer 0 0 0 0 0 2 2
Papillary renal cell carcinoma type 1 0 0 0 0 0 2 2
Uterine corpus endometrial carcinoma 0 0 0 0 0 2 2
Wolff-Parkinson-White pattern 0 0 2 0 0 0 2
Brugada syndrome 0 0 1 0 0 0 1
Brugada syndrome 9 0 0 1 0 0 0 1
Cardiomyopathy; Hypertrophic cardiomyopathy 0 0 0 0 1 0 1
Catecholaminergic polymorphic ventricular tachycardia 1 0 0 1 0 0 0 1
Dilated cardiomyopathy 1S 0 0 0 1 0 0 1
Dilated cardiomyopathy 3B 0 0 1 0 0 0 1
Familial atrial fibrillation 0 0 1 0 0 0 1
Familial pancreatic carcinoma 0 0 0 0 0 1 1
Hypertrophic cardiomyopathy 1 0 0 1 0 0 0 1
Hypertrophic cardiomyopathy; Ventricular tachycardia 0 0 0 1 0 0 1
Inborn genetic diseases 0 0 1 0 0 0 1
Left ventricular noncompaction cardiomyopathy 0 0 1 0 0 0 1
Malignant lymphoma, large B-cell, diffuse 0 0 0 0 0 1 1
Malignant tumor of esophagus 0 0 0 0 0 1 1
Malignant tumor of urinary bladder 0 0 0 0 0 1 1
Ovarian cancer 0 0 0 0 0 1 1
Premature ventricular contraction 0 0 0 1 0 0 1
Primary dilated cardiomyopathy; Long QT syndrome 0 0 0 1 0 0 1
Spinocerebellar ataxia type 19/22 0 0 1 0 0 0 1
Squamous cell carcinoma of the head and neck 0 0 0 0 0 1 1
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 56
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 0 0 808 473 83 0 1364
Ambry Genetics 0 0 732 406 10 0 1148
GeneDx 0 1 210 155 159 0 525
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 50 59 38 3 150
Fulgent Genetics, Fulgent Genetics 0 0 106 19 2 0 127
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 0 0 24 45 52 0 121
Clinical Genetics, Academic Medical Center 0 0 10 7 62 0 79
PreventionGenetics, part of Exact Sciences 0 0 19 31 18 0 68
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario 0 0 27 17 22 0 66
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 8 36 22 0 66
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 8 30 12 0 50
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 8 24 16 0 48
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 0 0 4 22 19 0 45
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 8 12 21 0 41
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 0 0 21 6 10 0 37
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 35 35
CeGaT Center for Human Genetics Tuebingen 0 0 8 11 6 0 25
Breakthrough Genomics, Breakthrough Genomics 0 0 3 21 0 0 24
AiLife Diagnostics, AiLife Diagnostics 0 0 15 0 0 0 15
Blueprint Genetics 0 0 12 0 0 0 12
Genome-Nilou Lab 0 0 0 0 12 0 12
Stanford Center for Inherited Cardiovascular Disease, Stanford University 0 0 11 0 0 0 11
Mayo Clinic Laboratories, Mayo Clinic 0 0 10 0 0 0 10
Center for Advanced Laboratory Medicine, UC San Diego Health, University of California San Diego 0 0 2 6 1 0 9
Revvity Omics, Revvity 0 0 8 0 0 0 8
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 6 0 0 0 6
Clinical Genomics Laboratory, Stanford Medicine 0 0 5 0 0 0 5
Eurofins Ntd Llc (ga) 0 0 3 1 1 0 5
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 2 3 0 0 0 5
Neuberg Centre For Genomic Medicine, NCGM 0 0 5 0 0 0 5
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 3 0 0 0 3
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 3 0 0 0 3
Clinical Molecular Genetics Laboratory, Johns Hopkins All Children's Hospital 0 0 3 0 0 0 3
Institute of Human Genetics, University of Leipzig Medical Center 0 0 2 0 1 0 3
Klaassen Lab, Charite University Medicine Berlin 0 0 3 0 0 0 3
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 0 0 3 0 0 0 3
Baylor Genetics 0 0 2 0 0 0 2
Clinical Genetics Laboratory, Skane University Hospital Lund 0 0 2 0 0 0 2
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 2 0 0 0 2
Agnes Ginges Centre for Molecular Cardiology, Centenary Institute 0 0 1 0 0 0 1
Centre for Medical Genetics, Mumbai 0 0 0 1 0 0 1
Daryl Scott Lab, Baylor College of Medicine 0 0 1 0 0 0 1
Genetics and Genomics Program, Sidra Medicine 0 0 0 1 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 1 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 1 0 0 0 1
Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen 0 0 0 1 0 0 1
Institute of Human Genetics, University of Wuerzburg 0 0 1 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 1 0 0 0 1
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 1 0 0 1
Mendelics 0 0 0 0 1 0 1
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease, Montreal Heart Institute 0 0 1 0 0 0 1
New York Genome Center 0 0 1 0 0 0 1
OMIM 1 0 0 0 0 0 1
Petrovsky National Research Centre of Surgery, The Federal Agency for Scientific Organizations 0 0 1 0 0 0 1
Phosphorus, Inc. 0 0 1 0 0 0 1

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