ClinVar Miner

Variants in gene HOXB13

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Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
7 2 1589 384 240 2 1 1929

Condition and significance breakdown #

Total conditions: 13
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Condition pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
not provided 1 1 745 291 12 2 0 1033
Hereditary cancer-predisposing syndrome 0 2 603 277 4 0 0 885
Prostate cancer, hereditary, 1 0 0 762 0 0 0 0 762
Prostate cancer, hereditary, 9 1 2 47 27 232 0 1 294
HOXB13-related disorder 1 0 23 16 0 0 0 40
not specified 0 0 7 4 13 0 0 21
Gastric cancer 6 0 0 0 0 0 0 6
Prostate cancer 0 0 3 2 0 0 0 5
Familial prostate cancer 1 1 0 0 0 0 0 2
Breast and/or ovarian cancer 0 1 0 0 0 0 0 1
Carcinoma of pancreas 0 1 0 0 0 0 0 1
HOXB13-Related Cancer Predisposition 1 0 0 0 0 0 0 1
Prostate cancer susceptibility 1 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 46
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
Labcorp Genetics (formerly Invitae), Labcorp 0 0 717 285 7 2 0 1011
Ambry Genetics 0 2 601 275 4 0 0 882
Laboratory of Virology, Microbiology, Quality and Medical Biotechnologies, Faculty of Sciences and Techniques - Mohammedia, Hassan II University of Casablanca 0 0 762 0 0 0 0 762
Myriad Genetics, Inc. 0 0 0 17 231 0 0 248
GeneDx 1 0 128 10 8 0 0 147
Quest Diagnostics Nichols Institute San Juan Capistrano 1 0 52 7 10 0 0 70
PreventionGenetics, part of Exact Sciences 1 0 23 16 0 0 0 40
Department of Pathology and Laboratory Medicine, Sinai Health System 1 0 26 11 1 0 0 39
Fulgent Genetics, Fulgent Genetics 0 2 21 0 0 0 0 23
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 1 1 5 2 8 0 0 17
Sema4, Sema4 0 0 5 9 0 0 0 14
CeGaT Center for Human Genetics Tuebingen 0 1 0 7 2 0 0 10
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 2 4 0 0 6
Laboratory for Genotyping Development, RIKEN 6 0 0 0 0 0 0 6
Molecular Pathology, Peter Maccallum Cancer Centre 0 0 6 0 0 0 0 6
Breakthrough Genomics, Breakthrough Genomics 0 0 0 1 4 0 0 5
Mayo Clinic Laboratories, Mayo Clinic 1 0 1 1 2 0 0 5
Genetic Services Laboratory, University of Chicago 0 0 1 2 0 0 0 3
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 1 2 0 0 0 0 3
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 1 2 0 0 0 0 3
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 1 0 0 1 0 0 2
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 1 1 0 0 0 0 2
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 1 0 1 0 0 0 0 2
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 1 1 0 0 0 0 0 2
Revvity Omics, Revvity 0 0 2 0 0 0 0 2
Baylor Genetics 0 1 0 0 0 0 0 1
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario 0 1 0 0 0 0 0 1
CZECANCA consortium 0 1 0 0 0 0 0 1
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 1 0 0 0 0 0 1
Clinical Genetics Laboratory, University Hospital Schleswig-Holstein 0 0 1 0 0 0 0 1
Dasa 1 0 0 0 0 0 0 1
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 0 1 0 0 0 0 0 1
Department of Pediatric Oncology, Hematology and Clinical Immunology, University Clinics Duesseldorf 0 0 1 0 0 0 0 1
Genetics and Molecular Pathology, SA Pathology 1 0 0 0 0 0 0 1
Genome Diagnostics Laboratory, Amsterdam University Medical Center 1 0 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 0 1 1
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 1 0 0 0 0 0 0 1
Illumina Laboratory Services, Illumina 1 0 0 0 0 0 0 1
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 0 1 0 0 0 0 0 1
MGZ Medical Genetics Center 0 1 0 0 0 0 0 1
Mendelics 1 0 0 0 0 0 0 1
OMIM 1 0 0 0 0 0 0 1
Otogenetics 1 0 0 0 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 1 0 0 0 0 0 0 1
Unidad de Genética Molecular HGU Elche, Hospital General Universitario de Elche 0 0 1 0 0 0 0 1
University of Washington Department of Laboratory Medicine, University of Washington 1 0 0 0 0 0 0 1

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