ClinVar Miner

Variants in gene FLCN

Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
424 127 1456 1140 427 49 2941

Condition and significance breakdown #

Total conditions: 41
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Birt-Hogg-Dube syndrome 323 51 1012 764 71 9 2169
Hereditary cancer-predisposing syndrome 179 33 806 582 58 0 1631
Birt-Hogg-Dube syndrome 1 40 9 62 174 297 0 569
not provided 122 43 253 119 66 0 557
not specified 5 0 56 118 32 19 205
FLCN-related disorder 11 3 37 64 4 0 119
Familial spontaneous pneumothorax 12 1 59 13 23 0 108
Familial spontaneous pneumothorax; Nonpapillary renal cell carcinoma; Colorectal cancer; Birt-Hogg-Dube syndrome 1 10 5 81 3 2 0 101
Birt-Hogg-Dube syndrome; Familial spontaneous pneumothorax; 17p11.2 microduplication syndrome; Nonpapillary renal cell carcinoma; Colorectal cancer 5 2 52 26 2 0 87
Ovarian cancer 0 4 0 0 8 0 12
Pneumothorax - familial 5 5 0 0 0 0 10
Ovarian serous cystadenocarcinoma 0 0 0 0 0 9 9
Birt-Hogg-Dube syndrome; Familial spontaneous pneumothorax; 17p11.2 microduplication syndrome; Carcinoma of colon; Nonpapillary renal cell carcinoma 1 1 4 0 0 0 6
Multiple monogenic benign skin tumours 2 1 1 0 0 0 4
Cervical cancer 0 0 0 0 0 3 3
Familial spontaneous pneumothorax; 17p11.2 microduplication syndrome; Nonpapillary renal cell carcinoma; Colorectal cancer; Birt-Hogg-Dube syndrome 1 0 0 1 1 1 0 3
Sarcoma 0 0 0 0 0 3 3
Uterine corpus endometrial carcinoma 0 0 0 0 0 3 3
17p11.2 microduplication syndrome 1 0 1 0 0 0 2
Acute myeloid leukemia 0 0 0 0 0 2 2
Carcinoma of colon 2 0 0 0 0 0 2
Familial cancer of breast 0 0 0 0 0 2 2
Lung cancer 0 0 0 0 0 2 2
Malignant tumor of esophagus 0 0 0 0 0 2 2
Neoplasm 2 0 0 0 0 0 2
See cases 0 1 1 0 0 0 2
Chromophobe renal cell carcinoma 1 0 0 0 0 0 1
Colon adenocarcinoma 0 0 0 0 0 1 1
Exstrophy-epispadias complex 0 0 1 0 0 0 1
Gastric cancer 0 0 0 0 0 1 1
Hepatoblastoma 0 0 1 0 0 0 1
Hepatocellular carcinoma 0 0 0 0 0 1 1
Hereditary breast ovarian cancer syndrome 0 0 1 0 0 0 1
Hereditary renal cancer 0 1 0 0 0 0 1
Hypoparathyroidism 1 0 0 0 0 0 1
Inherited renal cancer 1 0 0 0 0 0 1
Melanoma 0 0 0 0 0 1 1
Mesothelioma 0 0 0 0 0 1 1
Nonpapillary renal cell carcinoma; Colorectal cancer; Birt-Hogg-Dube syndrome 1 0 0 0 1 0 0 1
Pilocytic astrocytoma 0 1 0 0 0 0 1
Pulmonary arterial hypertension 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 95
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 249 25 951 756 33 0 2014
Ambry Genetics 178 28 777 577 49 0 1609
Myriad Genetics, Inc. 66 17 0 172 300 0 555
GeneDx 73 10 180 88 47 0 398
Fulgent Genetics, Fulgent Genetics 10 8 135 28 2 0 183
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 15 3 51 96 8 0 173
Quest Diagnostics Nichols Institute San Juan Capistrano 34 4 72 29 27 0 166
PreventionGenetics, part of Exact Sciences 11 3 37 67 10 0 128
Baylor Genetics 11 2 114 0 0 0 127
Illumina Laboratory Services, Illumina 0 0 54 14 47 0 90
Division of Respiratory Medicine of Juntendo University, Juntendo University Faculty of Medicine and Graduate School of Medicine 85 0 0 0 0 0 85
Sema4, Sema4 1 1 34 31 6 0 73
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 41 4 12 1 2 0 60
Mayo Clinic Laboratories, Mayo Clinic 20 19 12 2 3 0 56
CeGaT Center for Human Genetics Tuebingen 10 1 13 26 5 0 55
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 23 1 10 12 7 0 53
Breakthrough Genomics, Breakthrough Genomics 0 0 3 11 37 0 51
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 14 4 4 6 9 0 37
Eurofins Ntd Llc (ga) 20 0 4 1 8 0 33
Department of Pathology and Laboratory Medicine, Sinai Health System 4 0 7 5 7 0 23
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 22 22
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 2 1 17 0 0 0 20
ITMI 0 0 0 0 0 19 19
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 6 13 0 19
OMIM 18 0 0 0 0 0 18
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 3 0 12 1 0 0 16
Clinical Genetics and Genomics, Karolinska University Hospital 12 1 0 0 0 0 13
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 1 0 0 5 7 0 13
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 4 0 0 8 0 12
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 2 0 1 3 5 0 11
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 0 0 8 0 2 0 10
Clinical Genetics Laboratory, Skane University Hospital Lund 6 4 0 0 0 0 10
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 2 6 2 0 10
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 3 0 1 6 0 10
Molecular Pathology, Peter Maccallum Cancer Centre 5 2 2 1 0 0 10
NHS Central & South Genomic Laboratory Hub 5 5 0 0 0 0 10
Molecular Diagnostics Laboratory, Catalan Institute of Oncology 2 4 2 0 1 0 9
MGZ Medical Genetics Center 3 4 1 0 0 0 8
Revvity Omics, Revvity 1 0 7 0 0 0 8
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 1 1 5 0 7
Mendelics 2 0 2 2 1 0 7
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 0 2 4 0 0 6
Genetics Laboratory, Great Ormond Street Hospital NHS Foundation Trust, North Thames Genomic Laboratory Hub 3 1 1 0 0 0 5
Genetics and Molecular Pathology, SA Pathology 4 0 0 1 0 0 5
Institute of Human Genetics, University of Leipzig Medical Center 4 0 0 1 0 0 5
CSER _CC_NCGL, University of Washington 1 0 3 0 0 0 4
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 4 0 0 4
Johns Hopkins Genomics, Johns Hopkins University 1 0 3 0 0 0 4
Dasa 3 0 0 0 0 0 3
GeneReviews 0 0 0 0 0 3 3
Genetic Services Laboratory, University of Chicago 0 0 0 2 1 0 3
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 3 3
GenomeConnect, ClinGen 0 0 0 0 0 3 3
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 3 0 0 0 0 0 3
Juno Genomics, Hangzhou Juno Genomics, Inc 3 0 0 0 0 0 3
Laboratory of Genetics, Children's Clinical University Hospital Latvia 1 0 0 2 0 0 3
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 3 0 0 0 0 0 3
Centre for Mendelian Genomics, University Medical Centre Ljubljana 1 0 1 0 0 0 2
Department of Molecular Diagnostics, Institute of Oncology Ljubljana 0 2 0 0 0 0 2
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 1 0 1 0 0 0 2
Genome-Nilou Lab 0 0 0 0 2 0 2
Hereditary Cancer Laboratory, Hospital Universitario 12 de Octubre 0 0 0 0 2 0 2
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 2 0 0 0 0 0 2
Institute of Human Genetics, Cologne University 1 0 1 0 0 0 2
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 1 0 0 0 1 0 2
Laboratory of Medical Genetics, National & Kapodistrian University of Athens 1 0 1 0 0 0 2
3billion 0 1 0 0 0 0 1
Academic Department of Medical Genetics, University of Cambridge 0 0 1 0 0 0 1
Bioscientia Institut fuer Medizinische Diagnostik GmbH, Sonic Healthcare 0 1 0 0 0 0 1
Cambridge Genomics Laboratory, East Genomic Laboratory Hub, NHS Genomic Medicine Service 1 0 0 0 0 0 1
Center for Human Genetics and Genomic Medicine, Uniklinik Rwth Aachen 0 1 0 0 0 0 1
Centre of Medical Genetics, University Hospital Muenster 0 0 1 0 0 0 1
Clinical Genetics Laboratory, Region Ostergotland 1 0 0 0 0 0 1
Department of Human Genetics, Hannover Medical School 1 0 0 0 0 0 1
Department of Medical Genetics, Gazi University 1 0 0 0 0 0 1
Department of Pulmonary and Critical Care Medicine, The Affiliated Cangnan Hospital of Wenzhou Medical University 1 0 0 0 0 0 1
Department of Traditional Chinese Medicine, Fujian Provincial Hospital 1 0 0 0 0 0 1
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 0 0 1 0 0 0 1
Genetics Department, Catlab 1 0 0 0 0 0 1
Gharavi Laboratory, Columbia University 1 0 0 0 0 0 1
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 0 1 0 0 0 0 1
Institute of Immunology and Genetics Kaiserslautern 1 0 0 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 1 0 0 0 1
Laboratorio de I+D, Fundación Centro Médico de Asturias 0 0 0 1 0 0 1
MVZ Martinsried, Medicover Genetics 0 1 0 0 0 0 1
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 0 1 0 0 0 0 1
Molecular Oncology - Human Genetics Lab, University of Sao Paulo 0 0 1 0 0 0 1
Molecular Oncology Research Center, Barretos Cancer Hospital 0 0 1 0 0 0 1
Neuberg Centre For Genomic Medicine, NCGM 1 0 0 0 0 0 1
Obstetrics and Gynecology Department, Johns Hopkins School Of Medicine 0 0 1 0 0 0 1
Otogenetics 0 0 1 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 1 0 0 0 0 0 1
Suna and Inan Kirac Foundation Neurodegeneration Research Laboratory, Koc University 1 0 0 0 0 0 1
UCLA Clinical Genomics Center, UCLA 1 0 0 0 0 0 1
Variantyx, Inc. 1 0 0 0 0 0 1

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