ClinVar Miner

Variants in gene FANCM

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Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
171 91 2651 1201 86 34 4010

Condition and significance breakdown #

Total conditions: 46
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Fanconi anemia 159 27 1390 682 50 0 2305
Inborn genetic diseases 0 0 1422 744 0 0 2166
not provided 14 50 820 179 52 3 1075
Spermatogenic failure 28; Premature ovarian failure 15 2 12 234 29 0 0 276
FANCM-related disorder 3 9 47 47 6 0 112
Hereditary cancer-predisposing syndrome 2 2 62 29 4 0 97
not specified 0 0 41 21 38 0 91
Premature ovarian failure 15 5 2 4 2 29 0 42
Spermatogenic failure 28 7 1 28 0 6 0 42
Hereditary breast ovarian cancer syndrome 0 3 21 1 0 0 25
Hereditary cancer 0 0 1 11 0 0 12
Ovarian serous cystadenocarcinoma 0 0 0 0 0 7 7
Fanconi anemia complementation group A 0 1 3 2 0 0 6
Sarcoma 0 0 0 0 0 5 5
Cervical cancer 0 0 0 0 0 4 4
Familial cancer of breast 3 0 0 0 0 1 4
Acute myeloid leukemia 0 0 0 0 0 3 3
Fanconi anemia, complementation group M 0 0 2 0 0 1 3
Hepatocellular carcinoma 0 0 0 0 0 3 3
Malignant tumor of esophagus 0 0 0 0 0 3 3
Nonpapillary renal cell carcinoma 0 0 0 0 0 3 3
Thymoma 0 0 0 0 0 3 3
Uterine corpus endometrial carcinoma 0 0 0 0 0 3 3
Colon adenocarcinoma 0 0 0 0 0 2 2
FANCM Fanconi-like genomic instability disorder 0 2 0 0 0 0 2
Germ cell tumor of testis 0 0 0 0 0 2 2
Hepatoblastoma 0 0 2 0 0 0 2
Melanoma 0 0 0 0 0 2 2
Adrenocortical carcinoma, hereditary 0 0 0 0 0 1 1
Aplastic anemia 0 0 1 0 0 0 1
Azoospermia 1 0 0 0 0 0 1
Cholangiocarcinoma 0 0 0 0 0 1 1
Clear cell carcinoma of kidney 0 0 0 0 0 1 1
Colorectal cancer 0 0 0 0 0 1 1
Gastric cancer 0 0 0 0 0 1 1
Hereditary nonpolyposis colorectal carcinoma 1 0 0 0 0 0 1
Lung cancer 0 0 0 0 0 1 1
Male infertility with azoospermia or oligozoospermia due to single gene mutation 1 0 0 0 0 0 1
Male infertility with spermatogenesis disorder 1 0 0 0 0 0 1
Malignant germ cell tumor of ovary 1 0 0 0 0 0 1
Malignant lymphoma, large B-cell, diffuse 0 0 0 0 0 1 1
Malignant tumor of urinary bladder 0 0 0 0 0 1 1
Retinoblastoma 0 1 0 0 0 0 1
See cases 0 1 0 0 0 0 1
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 1 1
Uterine carcinosarcoma 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 55
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 159 24 1390 688 46 0 2307
Ambry Genetics 0 0 1422 744 0 0 2166
GeneDx 1 39 661 75 45 0 821
Quest Diagnostics Nichols Institute San Juan Capistrano 4 9 297 70 33 0 413
Fulgent Genetics, Fulgent Genetics 0 9 233 29 0 0 271
PreventionGenetics, part of Exact Sciences 3 9 46 50 20 0 128
Sema4, Sema4 2 2 60 26 3 0 93
CeGaT Center for Human Genetics Tuebingen 9 6 15 49 2 0 81
Genetic Services Laboratory, University of Chicago 1 1 29 17 11 0 59
Breakthrough Genomics, Breakthrough Genomics 0 0 8 24 20 0 52
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 2 0 33 1 0 0 36
Mendelics 2 1 15 15 1 0 34
Baylor Genetics 3 2 28 0 0 0 33
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 30 30
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 2 26 0 28
Cancer Genomics Group, Japanese Foundation For Cancer Research 0 2 21 1 0 0 24
Revvity Omics, Revvity 1 4 9 0 0 0 14
GeneKor MSA 0 0 0 0 13 0 13
Department of Pathology and Laboratory Medicine, Sinai Health System 1 3 6 0 2 0 12
Mayo Clinic Laboratories, Mayo Clinic 0 1 1 4 6 0 12
OMIM 8 0 2 0 0 0 10
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 0 0 8 0 8
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 2 6 0 8
Dasa 2 0 1 2 1 0 6
Genome-Nilou Lab 0 0 0 0 6 0 6
Gharavi Laboratory, Columbia University 0 0 6 0 0 0 6
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 1 5 0 6
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 1 1 3 0 0 0 5
Molecular Diagnostics Laboratory, Catalan Institute of Oncology 0 0 2 1 1 0 4
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 3 0 0 0 3
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 2 1 0 3
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 0 3 0 0 0 0 3
First Genomix Gene Laboratory, Genetic Diagnostics Department 1 2 0 0 0 0 3
Neuberg Centre For Genomic Medicine, NCGM 0 0 3 0 0 0 3
Division of Medical Genetics, University of Washington 2 0 0 0 0 0 2
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 2 2
GenomeConnect, ClinGen 0 0 0 0 0 2 2
Laan Lab, Human Genetics Research Group, University of Tartu 2 0 0 0 0 0 2
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 1 0 1 0 0 0 2
Molecular Oncology - Human Genetics Lab, University of Sao Paulo 0 0 2 0 0 0 2
Center for Individualized Medicine, Mayo Clinic 0 1 0 0 0 0 1
Daryl Scott Lab, Baylor College of Medicine 0 0 1 0 0 0 1
Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences 1 0 0 0 0 0 1
Genetics and Molecular Pathology, SA Pathology 0 0 1 0 0 0 1
Genetics and Personalized Medicine Clinic, Tartu University Hospital 0 1 0 0 0 0 1
Genetics of Infertility and Preimplantation Genetic Diagnosis, Centre Hospitalier Universitaire Grenoble Alpes 1 0 0 0 0 0 1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 0 0 0 0 1 0 1
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 0 0 1 0 0 1
Institute of Human Genetics, University of Leipzig Medical Center 0 0 0 0 1 0 1
Institute of Immunology and Genetics Kaiserslautern 1 0 0 0 0 0 1
Laboratorio de I+D, Fundación Centro Médico de Asturias 0 0 0 1 0 0 1
Laboratory of Genetics, Children's Clinical University Hospital Latvia 0 1 0 0 0 0 1
Medical Genetics, Medical University Pleven 0 1 0 0 0 0 1
Reproductive Development, Murdoch Childrens Research Institute 0 1 0 0 0 0 1
Zero Childhood Cancer Program, Children's Cancer Institute 0 1 0 0 0 0 1

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