ClinVar Miner

Variants in gene DNAH8

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
123 45 1189 967 362 47 2648

Condition and significance breakdown #

Total conditions: 30
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Primary ciliary dyskinesia 118 32 796 893 147 1 1985
not specified 0 0 576 20 46 0 642
not provided 0 3 90 79 257 1 427
DNAH8-related disorder 0 3 12 47 2 0 64
Spermatogenic failure 46 6 12 29 8 1 1 56
Ovarian serous cystadenocarcinoma 0 0 0 0 0 10 10
Acute myeloid leukemia 0 0 0 0 0 6 6
Lung cancer 0 0 0 0 0 6 6
Cervical cancer 0 0 0 0 0 5 5
Familial cancer of breast 0 0 0 0 0 4 4
Uterine corpus endometrial carcinoma 0 0 0 0 0 4 4
Malignant tumor of esophagus 0 0 0 0 0 3 3
Malignant tumor of urinary bladder 0 0 0 0 0 3 3
Papillary renal cell carcinoma type 1 0 0 0 0 0 3 3
Sarcoma 0 0 0 0 0 3 3
Cholangiocarcinoma 0 0 0 0 0 2 2
Hepatocellular carcinoma 0 0 0 0 0 2 2
Thymoma 0 0 0 0 0 2 2
Uterine carcinosarcoma 0 0 0 0 0 2 2
Autism 0 0 1 0 0 0 1
EBV-positive nodal T- and NK-cell lymphoma 0 0 0 1 0 0 1
Gastric cancer 0 0 0 0 0 1 1
Inherited obesity 1 0 0 0 0 0 1
Lymphoma 0 0 0 0 0 1 1
Malignant lymphoma, large B-cell, diffuse 0 0 0 0 0 1 1
Melanoma 0 0 0 0 0 1 1
Primary ciliary dyskinesia; Spermatogenic failure 46 0 0 0 0 0 1 1
Prostate cancer 0 0 1 0 0 0 1
Recurrent infections 0 0 1 0 0 0 1
Recurrent respiratory infections; Recurrent infections of the middle ear 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 31
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 118 32 790 911 147 0 1998
Ambry Genetics 0 0 576 18 0 0 594
GeneDx 0 0 27 0 253 0 280
Mayo Clinic Laboratories, Mayo Clinic 0 1 23 12 43 0 79
PreventionGenetics, part of Exact Sciences 0 3 12 47 8 0 70
CeGaT Center for Human Genetics Tuebingen 0 0 14 36 4 0 54
Breakthrough Genomics, Breakthrough Genomics 0 0 25 20 0 0 45
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 43 43
Fulgent Genetics, Fulgent Genetics 0 0 18 8 1 0 27
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 1 1 14 0 16
UNC Molecular Genetics Laboratory, University of North Carolina at Chapel Hill 0 1 12 2 0 0 15
Revvity Omics, Revvity 0 1 7 0 0 0 8
Department of Pathology and Laboratory Medicine, Sinai Health System 0 4 3 0 0 0 7
OMIM 5 0 1 0 0 0 6
First Genomix Gene Laboratory, Genetic Diagnostics Department 1 4 0 0 0 0 5
Johns Hopkins Genomics, Johns Hopkins University 0 0 5 0 0 0 5
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 4 4
Genetics and Molecular Pathology, SA Pathology 0 0 3 0 0 0 3
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 3 0 0 0 0 3
Laboratory of Genetics, Children's Clinical University Hospital Latvia 0 2 0 1 0 0 3
AiLife Diagnostics, AiLife Diagnostics 0 0 2 0 0 0 2
Bionano Laboratories 0 0 2 0 0 0 2
Centre for Addiction & Mental Health, Centre for Addiction & Mental Health 0 0 1 0 0 0 1
Clinical Genomics Laboratory, Washington University in St. Louis 0 0 1 0 0 0 1
Cytogenetics and Molecular Genetics Section, Pathology Unit, BARC Hospital, Bhabha Atomic Research Centre 1 0 0 0 0 0 1
Department of Clinical Pathology, School of Medicine, Fujita Health University 0 0 0 1 0 0 1
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 0 0 0 1
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 1 0 0 0 1
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 0 0 1 0 0 0 1
Institute of Human Genetics, University of Leipzig Medical Center 0 0 1 0 0 0 1
Science for Life laboratory, Karolinska Institutet 0 0 1 0 0 0 1

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