ClinVar Miner

Variants in gene CUBN

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign affects not provided total
97 160 1363 830 316 4 50 2525

Condition and significance breakdown #

Total conditions: 35
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Condition pathogenic likely pathogenic uncertain significance likely benign benign affects not provided total
Imerslund-Grasbeck syndrome 66 63 518 543 143 0 3 1322
Imerslund-Grasbeck syndrome type 1; Proteinuria, chronic benign 16 82 517 51 2 0 0 667
not provided 15 16 166 199 231 0 0 598
Inborn genetic diseases 4 0 457 70 0 0 0 531
Imerslund-Grasbeck syndrome type 1 18 8 231 34 82 0 0 372
CUBN-related disorder 9 9 25 99 14 0 0 156
not specified 1 0 12 12 71 0 0 94
Proteinuria, chronic benign 9 12 9 0 0 4 0 31
Ovarian serous cystadenocarcinoma 0 0 0 0 0 0 9 9
Clear cell carcinoma of kidney 0 0 0 0 0 0 8 8
Uterine corpus endometrial carcinoma 0 0 0 0 0 0 8 8
Acute myeloid leukemia 0 0 0 0 0 0 7 7
Gastric cancer 0 0 0 0 0 0 7 7
See cases 1 1 2 0 3 0 0 7
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 0 7 7
Melanoma 0 0 0 0 0 0 6 6
Sarcoma 0 0 0 0 0 0 5 5
Autosomal recessive CUBN-related disorders 1 2 0 0 0 0 0 3
Familial cancer of breast 0 0 0 0 0 0 3 3
Lung cancer 0 0 0 0 0 0 3 3
Malignant tumor of esophagus 0 0 0 0 0 0 3 3
Proteinuria 0 3 0 0 0 0 0 3
Malignant tumor of urinary bladder 0 0 0 0 0 0 2 2
Papillary renal cell carcinoma type 1 0 0 0 0 0 0 2 2
Thymoma 0 0 0 0 0 0 2 2
Adrenocortical carcinoma, hereditary 0 0 0 0 0 0 1 1
Autism spectrum disorder 0 1 0 0 0 0 0 1
Cervical cancer 0 0 0 0 0 0 1 1
Cholangiocarcinoma 0 0 0 0 0 0 1 1
Chronic kidney disease 1 0 0 0 0 0 0 1
Focal segmental glomerulosclerosis 0 0 1 0 0 0 0 1
HP:0004341 0 0 1 0 0 0 0 1
Hepatocellular carcinoma 0 0 0 0 0 0 1 1
Nonpapillary renal cell carcinoma 0 0 0 0 0 0 1 1
Uveal melanoma 0 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 66
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign affects not provided total
Labcorp Genetics (formerly Invitae), Labcorp 65 23 505 552 141 0 0 1286
Fulgent Genetics, Fulgent Genetics 15 76 515 51 2 0 0 659
Ambry Genetics 4 0 457 70 0 0 0 531
GeneDx 7 7 85 127 213 0 0 439
Illumina Laboratory Services, Illumina 0 0 217 34 76 0 0 327
Breakthrough Genomics, Breakthrough Genomics 0 0 13 60 95 0 0 168
PreventionGenetics, part of Exact Sciences 7 8 24 99 14 0 0 152
Mayo Clinic Laboratories, Mayo Clinic 0 1 28 14 69 0 0 112
CeGaT Center for Human Genetics Tuebingen 1 2 25 35 2 0 0 65
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 2 1 20 9 31 0 0 63
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 0 47 47
Juha Muilu Group; Institute for Molecular Medicine Finland (FIMM) 0 27 0 0 0 0 0 27
Genome-Nilou Lab 0 0 0 0 25 0 0 25
Bioscientia Institut fuer Medizinische Diagnostik GmbH, Sonic Healthcare 3 9 11 0 0 0 0 23
Revvity Omics, Revvity 7 3 9 0 0 0 0 19
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 2 0 7 7 0 0 0 16
MVZ Medizinische Genetik Mainz 7 3 4 0 0 0 0 14
3billion 3 4 6 0 0 0 0 13
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 1 0 1 6 4 0 0 12
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 6 1 5 0 0 0 0 12
Eurofins Ntd Llc (ga) 2 0 6 3 0 0 0 11
OMIM 6 0 0 0 0 4 0 10
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 0 6 3 0 0 9
First Genomix Gene Laboratory, Genetic Diagnostics Department 1 6 0 0 0 0 0 7
Gharavi Laboratory, Columbia University 0 0 7 0 0 0 0 7
Baylor Genetics 0 0 6 0 0 0 0 6
Department of Pathology and Laboratory Medicine, Sinai Health System 0 3 3 0 0 0 0 6
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 1 2 1 0 2 0 0 6
Variantyx, Inc. 1 5 0 0 0 0 0 6
Clinical Genomics Laboratory, Washington University in St. Louis 0 0 4 0 0 0 0 4
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 2 0 2 0 0 0 0 4
Laboratory of Genetics, Children's Clinical University Hospital Latvia 0 1 0 3 0 0 0 4
Molecular Biology Laboratory, Fundació Puigvert 1 3 0 0 0 0 0 4
New York Genome Center 0 0 4 0 0 0 0 4
SingHealth Duke-NUS Institute of Precision Medicine 0 2 2 0 0 0 0 4
AiLife Diagnostics, AiLife Diagnostics 0 2 1 0 0 0 0 3
Centre of Medical Genetics, University Hospital Muenster 1 0 2 0 0 0 0 3
Eurofins-Biomnis 0 3 0 0 0 0 0 3
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 3 0 0 0 0 3
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 1 0 0 2 0 0 3
Athena Diagnostics 0 0 2 0 0 0 0 2
Cambridge Genomics Laboratory, East Genomic Laboratory Hub, NHS Genomic Medicine Service 0 2 0 0 0 0 0 2
Center of Genomic medicine, Geneva, University Hospital of Geneva 1 1 0 0 0 0 0 2
Genesolutions, Medical Genetics Institutes, Ho Chi Minh City, Vietnam 2 0 0 0 0 0 0 2
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 0 1 0 0 0 0 2
Genomic Research Center, Shahid Beheshti University of Medical Sciences 2 0 0 0 0 0 0 2
MGZ Medical Genetics Center 0 1 1 0 0 0 0 2
Mendelics 0 0 2 0 0 0 0 2
Molecular Diagnostics Lab, Nemours Children's Health, Delaware 1 0 1 0 0 0 0 2
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 0 0 1 0 0 0 0 1
Centre for Inherited Metabolic Diseases, Karolinska University Hospital 1 0 0 0 0 0 0 1
Clinical Genetics Laboratory, Skane University Hospital Lund 0 0 1 0 0 0 0 1
Department of Pediatric Nephrology, Wuhan Children's Hospital 0 1 0 0 0 0 0 1
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 1 0 0 0 1
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 0 1 0 0 0 0 0 1
Gene Friend Way, National Innovation Center 0 1 0 0 0 0 0 1
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 1 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 1 1
GenomeConnect, ClinGen 0 0 0 0 0 0 1 1
Inserm U 954, Faculté de Médecine de Nancy 0 0 0 0 0 0 1 1
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 1 0 0 0 0 0 0 1
Laboratorio de Genética Hospitales Universitarios Virgen de las Nieves y Clínico San Cecilio (Granada, Spain), Hospitales Universitarios Virgen de las Nieves y Clínico San Cecilio (Granada, Spain) 0 1 0 0 0 0 0 1
Molecular Genetics, Labor Dr. Heidrich & Kollegen MVZ GmbH 0 0 1 0 0 0 0 1
Neuberg Centre For Genomic Medicine, NCGM 0 1 0 0 0 0 0 1
Richard Lifton Laboratory, Yale University School of Medicine 0 0 1 0 0 0 0 1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 0 1 0 0 0 0 1

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