ClinVar Miner

Variants in gene BARD1

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
569 300 2559 1608 704 48 4640

Condition and significance breakdown #

Total conditions: 43
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Familial cancer of breast 461 212 1915 1033 626 19 3624
Hereditary cancer-predisposing syndrome 251 112 1717 1082 35 0 3001
not provided 46 61 540 138 101 5 829
not specified 0 0 209 197 50 0 426
Hereditary breast ovarian cancer syndrome 14 13 43 27 24 0 118
BARD1-related cancer predisposition 15 8 77 12 1 0 112
BARD1-related disorder 4 1 40 43 0 0 88
Malignant tumor of breast 13 5 34 18 5 3 77
Breast and/or ovarian cancer 3 1 16 14 1 0 35
Gastric cancer 19 0 0 0 0 1 20
Hereditary cancer 0 0 5 7 0 0 12
Ovarian cancer 0 4 0 0 5 0 9
Acute myeloid leukemia 0 0 0 0 0 6 6
Triple-Negative Breast Cancer Finding 2 0 2 1 0 0 5
Familial ovarian cancer 0 0 3 1 0 0 4
Hepatocellular carcinoma 0 0 0 0 0 4 4
Neoplasm 0 2 2 0 0 0 4
Sarcoma 0 0 0 0 0 4 4
Breast carcinoma 2 0 1 0 0 0 3
Breast-ovarian cancer, familial, susceptibility to, 2 0 0 0 0 3 0 3
Carcinoma of colon 0 0 2 1 0 0 3
Familial pancreatic carcinoma 0 0 3 0 0 0 3
Malignant tumor of esophagus 0 0 0 0 0 3 3
Ovarian serous cystadenocarcinoma 0 0 0 0 0 3 3
Breast cancer, susceptibility to 2 0 0 0 0 0 2
Cervical cancer 0 0 0 0 0 2 2
Lung cancer 0 0 0 1 0 1 2
Thymoma 0 0 0 0 0 2 2
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 2 2
Uterine corpus endometrial carcinoma 0 0 0 0 0 2 2
Autosomal dominant BARD1-related disorders 1 0 0 0 0 0 1
Breast neoplasm 1 0 0 0 0 0 1
Cholangiocarcinoma 0 0 0 0 0 1 1
Clear cell carcinoma of kidney 0 0 0 0 0 1 1
Colon adenocarcinoma 0 0 0 0 0 1 1
Endometrial carcinoma 1 0 0 0 0 0 1
Familial adenomatous polyposis 2 0 0 1 0 0 0 1
Familial cancer of breast; BARD1-related cancer predisposition 1 0 0 0 0 0 1
Hepatoblastoma 0 1 0 0 0 0 1
Malignant tumor of thyroid gland 0 0 1 0 0 0 1
Melanoma 0 0 0 0 0 1 1
Multiple myeloma 0 1 0 0 0 0 1
Ovarian neoplasm 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 92
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 286 117 1846 897 47 0 3193
Ambry Genetics 232 85 1438 901 17 0 2673
Color Diagnostics, LLC DBA Color Health 73 22 707 397 22 0 1221
Myriad Genetics, Inc. 303 63 16 199 594 0 1175
GeneDx 21 38 426 142 104 0 731
Baylor Genetics 26 58 256 0 0 0 340
Quest Diagnostics Nichols Institute San Juan Capistrano 21 8 210 57 27 0 323
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 20 9 155 75 12 0 271
Department of Pathology and Laboratory Medicine, Sinai Health System 19 3 148 62 7 0 239
Sema4, Sema4 5 11 98 56 12 0 182
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 6 6 65 69 11 0 157
PreventionGenetics, part of Exact Sciences 4 1 52 51 18 0 126
Mendelics 4 2 56 22 9 0 93
Fulgent Genetics, Fulgent Genetics 8 2 54 3 3 0 70
CeGaT Center for Human Genetics Tuebingen 8 6 11 28 8 0 61
Counsyl 2 3 35 14 6 0 60
Molecular Pathology, Peter Maccallum Cancer Centre 9 5 42 0 0 0 56
KCCC/NGS Laboratory, Kuwait Cancer Control Center 3 0 26 5 19 0 53
National Health Laboratory Service, Universitas Academic Hospital and University of the Free State 2 0 9 16 24 0 51
Illumina Laboratory Services, Illumina 0 0 31 9 9 0 49
Breakthrough Genomics, Breakthrough Genomics 0 0 3 12 32 0 47
University of Washington Department of Laboratory Medicine, University of Washington 0 1 0 32 0 0 33
Institute for Biomarker Research, Medical Diagnostic Laboratories, L.L.C. 2 1 16 8 5 0 32
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario 0 0 16 14 1 0 31
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 1 0 7 7 15 0 30
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 1 2 25 0 0 0 28
Genetic Services Laboratory, University of Chicago 2 0 12 6 7 0 27
German Consortium for Hereditary Breast and Ovarian Cancer, University Hospital Cologne 2 7 10 7 0 0 26
Revvity Omics, Revvity 7 6 12 0 0 0 25
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 24 24
GeneKor MSA 1 1 13 0 9 0 24
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 4 3 15 2 0 0 24
Mayo Clinic Laboratories, Mayo Clinic 0 1 9 4 9 0 23
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 21 21
Molecular Diagnostics Laboratory, Catalan Institute of Oncology 0 9 7 5 0 0 21
Laboratory for Genotyping Development, RIKEN 19 0 0 0 0 0 19
MGZ Medical Genetics Center 2 3 14 0 0 0 19
Cancer Genomics Group, Japanese Foundation For Cancer Research 2 3 7 1 0 0 13
Institute of Human Genetics, University of Leipzig Medical Center 4 1 4 1 2 0 12
Hereditary Cancer Laboratory, Hospital Universitario 12 de Octubre 1 0 7 2 0 0 10
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 2 0 7 0 0 0 9
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 4 0 0 5 0 9
Centre for Mendelian Genomics, University Medical Centre Ljubljana 2 0 5 0 1 0 8
BRCAlab, Lund University 7 0 0 0 0 0 7
Clinical Genetics Laboratory, Skane University Hospital Lund 5 1 1 0 0 0 7
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 3 3 1 0 0 0 7
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 4 3 0 0 0 0 7
Cancer Genetics Service, National Cancer Centre Singapore 1 1 3 0 0 0 5
Dipartimento Di Medicina Di Precisione, Università Degli Studi Della Campania Luigi Vanvitelli 0 0 0 0 5 0 5
Juno Genomics, Hangzhou Juno Genomics, Inc 3 2 0 0 0 0 5
King Laboratory, University of Washington 5 0 0 0 0 0 5
Lab. Molecular Oncology, VUB, Free University of Brussels 2 0 2 1 0 0 5
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 1 2 2 0 5
Neuberg Centre For Genomic Medicine, NCGM 0 1 4 0 0 0 5
CZECANCA consortium 3 1 0 0 0 0 4
Dasa 2 1 1 0 0 0 4
Genesis Genomics 1 3 0 0 0 0 4
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 2 2 0 4
Laboratorio de I+D, Fundación Centro Médico de Asturias 0 0 1 2 1 0 4
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 3 0 0 3
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 0 3 0 0 0 0 3
GenomeConnect, ClinGen 0 0 0 0 0 3 3
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 2 1 0 0 0 0 3
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 0 0 3 0 3
Medical Genetics Laboratory, Umraniye Training and Research Hospital, University of Health Sciences 2 0 1 0 0 0 3
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 0 0 3 0 0 0 3
Department of Human Genetics, Hannover Medical School 0 0 2 0 0 0 2
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 1 0 0 2
Genomics Laboratory, Virgen de la Arrixaca University Clinical Hospital 0 0 2 0 0 0 2
Hauer Lab, Department Of Pediatric Oncology, Technical University Munich 2 0 0 0 0 0 2
Institute of Human Genetics, FAU Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg 1 1 0 0 0 0 2
OLLIN Analises Genomicas, OLLIN 1 0 1 0 0 0 2
Praxis Für Humangenetik, Biosciencia MVZ Labor Saar 1 0 1 0 0 0 2
ARUP Laboratories, Cytogenetics and Genomic Microarray, ARUP Laboratories 0 0 1 0 0 0 1
Catlab - Consorci Sanitari de Terrassa 0 0 1 0 0 0 1
Center of Medical Genetics and Primary Health Care 0 0 0 0 1 0 1
Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences 1 0 0 0 0 0 1
Diagnostics Centre, Carl Von Ossietzky University Oldenburg 1 0 0 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 1 0 0 0 0 0 1
Eurofins Ntd Llc (ga) 0 0 0 1 0 0 1
Genetics and Personalized Medicine Clinic, Tartu University Hospital 0 1 0 0 0 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 0 1 0 0 1
Genomics, Clalit Research Institute, Clalit Health Care 0 1 0 0 0 0 1
Institute of Human Genetics, University of Goettingen 0 0 1 0 0 0 1
Molecular Oncology - Human Genetics Lab, University of Sao Paulo 0 1 0 0 0 0 1
OMIM 1 0 0 0 0 0 1
Otogenetics 1 0 0 0 0 0 1
Undiagnosed Diseases Network, NIH 0 1 0 0 0 0 1
Vantari Genetics 0 0 0 0 1 0 1
Variantyx, Inc. 1 0 0 0 0 0 1
Xiao lab, Department of Pathology, Memorial Sloan Kettering Cancer Center 0 1 0 0 0 0 1
Yang An-Suei Laboratory, Academia Sinica 1 0 0 0 0 0 1

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