ClinVar Miner

Variants in gene AXIN2

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
184 59 2629 1635 778 31 4320

Condition and significance breakdown #

Total conditions: 35
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Oligodontia-cancer predisposition syndrome 129 23 1978 1188 702 9 3449
Hereditary cancer-predisposing syndrome 80 11 1562 975 86 0 2638
not provided 3 2 501 169 80 3 697
not specified 0 0 112 204 56 0 329
Colorectal cancer 2 15 279 1 0 1 298
AXIN2-related disorder 0 4 38 59 7 0 108
Oligodontia-cancer predisposition syndrome; Colorectal cancer 0 0 41 9 2 0 52
Oligodontia-cancer predisposition syndrome; Carcinoma of colon 0 0 9 0 1 0 10
Ovarian cancer 0 3 0 0 6 0 9
AXIN2-related attenuated familial adenomatous polyposis 1 5 0 0 0 1 7
Oligodontia-cancer predisposition syndrome; AXIN2-related attenuated familial adenomatous polyposis 4 0 0 0 0 0 4
Hepatocellular carcinoma 0 0 0 0 0 3 3
Oligodontia; Colorectal cancer 1 0 1 1 0 0 3
Thymoma 0 0 0 0 0 3 3
Thyroid cancer, nonmedullary, 1 0 0 0 0 0 3 3
Carcinoma of colon 2 0 0 0 0 0 2
Familial cancer of breast 0 0 0 0 0 2 2
Gastric cancer 0 0 0 0 0 2 2
Lung cancer 0 0 0 0 0 2 2
Malignant tumor of breast 0 0 1 0 1 0 2
Tooth agenesis, selective, 1 0 2 0 0 0 0 2
Uterine carcinosarcoma 0 0 0 0 0 2 2
Aganglionic megacolon 0 1 0 0 0 0 1
Colon adenocarcinoma 0 0 0 0 0 1 1
Colorectal carcinoma 0 1 0 0 0 0 1
Craniosynostosis syndrome 0 0 1 0 0 0 1
Ectodermal dysplasia 1 0 0 0 0 0 1
Familial prostate cancer 0 0 0 0 0 1 1
Hereditary cancer 0 0 0 1 0 0 1
Malignant tumor of esophagus 0 0 0 0 0 1 1
Medulloblastoma WNT activated 0 1 0 0 0 0 1
Neoplasm 0 1 0 0 0 0 1
Non-syndromic oligodontia 1 0 0 0 0 0 1
Ovarian serous cystadenocarcinoma 0 0 0 0 0 1 1
Sarcoma 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 76
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 104 12 1926 1141 46 0 3229
Ambry Genetics 80 9 1511 961 55 0 2616
Myriad Genetics, Inc. 47 5 0 145 652 0 849
GeneDx 1 1 391 182 74 0 649
Baylor Genetics 1 16 286 0 0 0 303
Quest Diagnostics Nichols Institute San Juan Capistrano 1 0 158 46 44 0 249
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital 0 1 96 101 12 0 210
Sema4, Sema4 0 2 103 72 28 0 205
Illumina Laboratory Services, Illumina 0 0 54 11 49 0 114
PreventionGenetics, part of Exact Sciences 0 2 37 59 16 0 114
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 0 1 15 25 28 0 69
Fulgent Genetics, Fulgent Genetics 0 0 49 9 3 0 61
CeGaT Center for Human Genetics Tuebingen 0 1 7 43 3 0 54
Breakthrough Genomics, Breakthrough Genomics 0 0 6 16 31 0 53
Mayo Clinic Laboratories, Mayo Clinic 0 0 16 14 13 0 43
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 3 4 35 0 42
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 9 15 15 0 39
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 31 0 0 0 31
Clinical Genetics, Academic Medical Center 1 0 1 16 12 0 30
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 6 7 9 0 22
Dr. Peter K. Rogan Lab, Western University 0 0 0 0 0 18 18
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 8 6 0 14
Laboratory of Diagnostic Genome Analysis, Leiden University Medical Center (LUMC) 0 0 0 10 4 0 14
Molecular Pathology, Peter Maccallum Cancer Centre 2 1 9 2 0 0 14
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 12 0 0 12
Genetic Services Laboratory, University of Chicago 0 0 1 7 4 0 12
Genome Diagnostics Laboratory, University Medical Center Utrecht 1 0 0 2 8 0 11
Centre de Biologie Pathologie Génétique, Centre Hospitalier Universitaire de Lille 5 5 0 0 0 0 10
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 1 6 3 0 10
GeneKor MSA 0 0 0 0 9 0 9
Laboratory of Molecular Epidemiology of Birth Defects, West China Second University Hospital, Sichuan University 0 3 0 0 6 0 9
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 8 8
Revvity Omics, Revvity 0 1 7 0 0 0 8
Genome-Nilou Lab 0 0 0 0 6 0 6
Laboratory of Genetics, Children's Clinical University Hospital Latvia 0 0 0 6 0 0 6
Mendelics 0 0 2 3 1 0 6
GenomeConnect, ClinGen 0 0 0 0 0 5 5
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 4 1 0 0 5
Molecular Diagnostics Laboratory, Catalan Institute of Oncology 0 0 0 0 5 0 5
CSER _CC_NCGL, University of Washington 1 0 1 2 0 0 4
Dasa 0 0 1 2 1 0 4
OMIM 4 0 0 0 0 0 4
Vantari Genetics 0 0 1 2 1 0 4
Department of Prosthodontics, Peking University School and Hospital of Stomatology 1 2 0 0 0 0 3
Hereditary Cancer Laboratory, Hospital Universitario 12 de Octubre 0 0 1 1 1 0 3
Laboratorio de I+D, Fundación Centro Médico de Asturias 0 0 0 0 3 0 3
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 0 0 0 0 3 0 3
Center of Excellence in Genomics and Precision Dentistry, Faculty of Dentistry, Chulalongkorn University 1 0 1 0 0 0 2
Center of Medical Genetics and Primary Health Care 0 0 1 0 1 0 2
Institute for Biomarker Research, Medical Diagnostic Laboratories, L.L.C. 0 0 0 0 2 0 2
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 2 0 0 0 2
MGZ Medical Genetics Center 0 1 1 0 0 0 2
Molecular Oncology Laboratory, Hospital Clínico San Carlos 0 0 2 0 0 0 2
University of Washington Department of Laboratory Medicine, University of Washington 1 0 0 1 0 0 2
Variantyx, Inc. 0 2 0 0 0 0 2
ARUP Laboratories, Cytogenetics and Genomic Microarray, ARUP Laboratories 0 0 1 0 0 0 1
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 1 0 0 0 1
Eurofins Ntd Llc (ga) 0 0 1 0 0 0 1
Genetics Laboratory, Great Ormond Street Hospital NHS Foundation Trust, North Thames Genomic Laboratory Hub 1 0 0 0 0 0 1
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 0 0 1 0 0 1
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 0 1 0 0 0 0 1
Helix 0 0 1 0 0 0 1
Human Genomics Unit, Institute for molecular medicine Finland (FIMM) 0 1 0 0 0 0 1
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 0 1 0 0 0 0 1
Institute of Human Genetics, Heidelberg University 0 1 0 0 0 0 1
Klinisk genetik och genomik Research, Gothenburg University 0 0 1 0 0 0 1
MVZ Medizinische Genetik Mainz 0 0 1 0 0 0 1
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 0 1 0 0 0 0 1
Molecular Genetics of Human Eye Development, Oxford Brookes University 0 1 0 0 0 0 1
Neuberg Centre For Genomic Medicine, NCGM 0 0 1 0 0 0 1
Praxis Für Humangenetik, Biosciencia MVZ Labor Saar 0 0 1 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 0 1 0 0 0 0 1
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University 1 0 0 0 0 0 1
Undiagnosed Diseases Network, NIH 0 0 1 0 0 0 1
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 0 0 1 0 0 0 1
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 0 0 1 0 0 0 1

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