If a variant has more than one submission, it may be counted in more than one significance column. If this is the
case, the total number of variants will be less than the sum of the other cells.
| pathogenic |
likely pathogenic |
uncertain significance |
likely benign |
benign |
not provided |
total |
|
17
|
15
|
533
|
126
|
1491
|
7
|
2172
|
Gene and significance breakdown #
Total genes and gene combinations: 22
| Gene or gene combination |
pathogenic |
likely pathogenic |
uncertain significance |
likely benign |
benign |
not provided |
total |
|
TTN
|
17
|
13
|
477
|
112
|
1303
|
7
|
1915
|
|
LOC101927055, TTN
|
0 |
1
|
4
|
2
|
20
|
0 |
27
|
|
LOC126806425, TTN
|
0 |
1
|
5
|
2
|
19
|
0 |
27
|
|
LOC126806430, TTN
|
0 |
0 |
6
|
3
|
17
|
0 |
26
|
|
LOC126806422, TTN
|
0 |
0 |
4
|
1
|
15
|
0 |
19
|
|
LOC126806421, TTN
|
0 |
0 |
4
|
0 |
12
|
0 |
16
|
|
LOC126806423, TTN
|
0 |
0 |
3
|
1
|
12
|
0 |
16
|
|
LOC126806424, TTN
|
0 |
0 |
2
|
0 |
13
|
0 |
15
|
|
LOC126806427, TTN
|
0 |
0 |
2
|
0 |
13
|
0 |
15
|
|
LOC126806431, TTN
|
0 |
0 |
6
|
0 |
9
|
0 |
15
|
|
LOC126806420, TTN
|
0 |
0 |
1
|
0 |
12
|
0 |
13
|
|
LOC126806426, TTN
|
0 |
0 |
6
|
0 |
7
|
0 |
12
|
|
LOC126806429, TTN
|
0 |
0 |
1
|
1
|
10
|
0 |
12
|
|
LOC129935183, TTN
|
0 |
0 |
3
|
2
|
7
|
0 |
12
|
|
LOC126806428, TTN
|
0 |
0 |
1
|
0 |
10
|
0 |
11
|
|
LOC126806433, TTN
|
0 |
0 |
5
|
0 |
4
|
0 |
9
|
|
LOC129935184, TTN
|
0 |
0 |
1
|
1
|
4
|
0 |
5
|
|
LOC126806432, TTN
|
0 |
0 |
1
|
1
|
0 |
0 |
2
|
|
LOC129935182, TTN
|
0 |
0 |
1
|
0 |
1
|
0 |
2
|
|
LOC129935185, TTN
|
0 |
0 |
0 |
0 |
1
|
0 |
1
|
|
LOC129935186, TTN
|
0 |
0 |
0 |
0 |
1
|
0 |
1
|
|
ZNF423
|
0 |
0 |
0 |
0 |
1
|
0 |
1
|
Submitter and significance breakdown #
| Submitter |
pathogenic |
likely pathogenic |
uncertain significance |
likely benign |
benign |
not provided |
total |
|
Illumina Laboratory Services, Illumina
|
0 |
0 |
474
|
120
|
1177
|
0 |
1771
|
|
Genome-Nilou Lab
|
0 |
0 |
0 |
0 |
635
|
0 |
635
|
|
Baylor Genetics
|
2
|
6
|
27
|
0 |
0 |
0 |
35
|
|
Centre for Mendelian Genomics, University Medical Centre Ljubljana
|
3
|
3
|
16
|
6
|
1
|
0 |
29
|
|
Phosphorus, Inc.
|
0 |
0 |
10
|
1
|
2
|
0 |
13
|
|
GeneReviews
|
4
|
0 |
0 |
0 |
0 |
4
|
8
|
|
Genetic Services Laboratory, University of Chicago
|
3
|
1
|
0 |
0 |
0 |
0 |
4
|
|
GenomeConnect, ClinGen
|
0 |
0 |
0 |
0 |
0 |
3
|
3
|
|
OMIM
|
3
|
0 |
0 |
0 |
0 |
0 |
3
|
|
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City
|
0 |
1
|
1
|
0 |
0 |
0 |
2
|
|
Mendelics
|
2
|
0 |
0 |
0 |
0 |
0 |
2
|
|
CENTOGENE GmbH and LLC - Guiding Precision Medicine
|
0 |
0 |
1
|
0 |
0 |
0 |
1
|
|
Center for Human Genetics and Genomic Medicine, Uniklinik Rwth Aachen
|
0 |
0 |
1
|
0 |
0 |
0 |
1
|
|
Clinical Genetics Laboratory, University Hospital Schleswig-Holstein
|
0 |
0 |
1
|
0 |
0 |
0 |
1
|
|
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology
|
0 |
1
|
0 |
0 |
0 |
0 |
1
|
|
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics
|
0 |
0 |
1
|
0 |
0 |
0 |
1
|
|
Inheritance Genetic Center
|
0 |
1
|
0 |
0 |
0 |
0 |
1
|
|
Institute of Human Genetics Munich, TUM University Hospital
|
1
|
0 |
0 |
0 |
0 |
0 |
1
|
|
Johns Hopkins Genomics, Johns Hopkins University
|
0 |
0 |
0 |
0 |
1
|
0 |
1
|
|
Juha Muilu Group; Institute for Molecular Medicine Finland (FIMM)
|
0 |
1
|
0 |
0 |
0 |
0 |
1
|
|
Kariminejad - Najmabadi Pathology & Genetics Center
|
0 |
1
|
0 |
0 |
0 |
0 |
1
|
|
Neuberg Centre For Genomic Medicine, NCGM
|
0 |
0 |
1
|
0 |
0 |
0 |
1
|
|
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas
|
0 |
0 |
1
|
0 |
0 |
0 |
1
|
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health behavior solely on the basis of information contained on
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