ClinVar Miner

Variants studied for Lynch syndrome 5

Coded as:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
977 187 414 441 1341 7 3091

Gene and significance breakdown #

Total genes and gene combinations: 7
Download table as spreadsheet
Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
MSH6 974 181 403 424 1329 7 3046
LOC129933707, MSH6 2 5 4 11 11 0 29
FBXO11, MSH6 1 0 3 4 1 0 9
LOC129933706, MSH6 0 0 2 2 0 0 4
MLH1 0 0 1 0 0 0 1
PMS2 0 0 1 0 0 0 1
RYR1 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 72
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Myriad Genetics, Inc. 937 115 94 314 1315 0 2775
Counsyl 17 18 174 72 2 0 283
Molecular Pathology, Peter Maccallum Cancer Centre 33 9 71 6 0 0 119
Mendelics 4 6 26 45 13 0 94
Illumina Laboratory Services, Illumina 1 1 61 8 10 0 81
KCCC/NGS Laboratory, Kuwait Cancer Control Center 1 1 13 18 35 0 68
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 2 2 40 1 0 0 45
Institute of Human Genetics, University of Leipzig Medical Center 14 9 4 0 0 0 27
Department of Pathology and Laboratory Medicine, Sinai Health System 2 0 11 8 0 0 21
MGZ Medical Genetics Center 7 6 8 0 0 0 21
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 5 0 1 1 13 0 20
Center for Human Genetics, Inc, Center for Human Genetics, Inc 2 1 11 5 0 0 19
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 4 0 0 5 9 0 18
Genetics and Molecular Pathology, SA Pathology 12 3 2 0 1 0 18
Neuberg Centre For Genomic Medicine, NCGM 1 0 16 0 0 0 17
University of Washington Department of Laboratory Medicine, University of Washington 0 10 3 2 0 0 15
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 2 1 8 1 1 0 13
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 4 8 0 0 0 12
Helix 2 0 9 0 0 0 11
OMIM 10 0 1 0 0 0 11
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 1 5 4 0 10
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 7 2 0 0 0 0 9
Genesis Genomics 7 1 0 0 0 0 8
Baylor Genetics 0 0 7 0 0 0 7
Human Genetics Bochum, Ruhr University Bochum 3 4 0 0 0 0 7
Institute of Immunology and Genetics Kaiserslautern 3 0 3 0 0 0 6
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 1 1 4 0 0 0 6
deCODE genetics, Amgen 1 5 0 0 0 0 6
Centre for Mendelian Genomics, University Medical Centre Ljubljana 4 1 0 0 0 0 5
Division of Medical Genetics, University of Washington 2 0 3 0 0 0 5
Juno Genomics, Hangzhou Juno Genomics, Inc 2 3 0 0 0 0 5
Department of Human Genetics, Hannover Medical School 2 0 2 0 0 0 4
Genome Diagnostics Laboratory, University Medical Center Utrecht 3 0 0 0 1 0 4
GenomeConnect, ClinGen 0 0 0 0 0 4 4
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 3 1 0 0 0 0 4
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 0 1 2 0 0 0 3
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 3 3
Johns Hopkins Genomics, Johns Hopkins University 1 0 0 2 0 0 3
3billion 1 1 0 0 0 0 2
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 1 0 0 0 1 0 2
Clinical Genetics Laboratory, Skane University Hospital Lund 1 1 0 0 0 0 2
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 0 2 0 0 0 2
Genetic Services Laboratory, University of Chicago 2 0 0 0 0 0 2
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 0 2 0 0 0 2
Institute of Human Genetics, FAU Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg 2 0 0 0 0 0 2
MVZ Martinsried, Medicover Genetics 1 0 1 0 0 0 2
MVZ Praenatalmedizin und Genetik Nuernberg 1 1 0 0 0 0 2
Molecular Genetics Department, Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology 0 2 0 0 0 0 2
Arcensus 0 1 0 0 0 0 1
CENTOGENE GmbH and LLC - Guiding Precision Medicine 0 0 1 0 0 0 1
Clinical Genetics Laboratory, University Hospital Schleswig-Holstein 1 0 0 0 0 0 1
Clinical Genomic Analysis (GENYSIS) Core, University of North Carolina at Chapel Hill 0 1 0 0 0 0 1
Clinical Genomics Laboratory, Washington University in St. Louis 0 1 0 0 0 0 1
Dasa 1 0 0 0 0 0 1
Department of Pediatrics, Memorial Sloan Kettering Cancer Center 1 0 0 0 0 0 1
EVOGEN 0 1 0 0 0 0 1
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 1 0 0 0 0 0 1
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 1 0 0 0 0 0 1
Hadassah Hebrew University Medical Center 1 0 0 0 0 0 1
Human Genetics Unit, University Of Colombo 1 0 0 0 0 0 1
Institute of Human Genetics Munich, TUM University Hospital 0 1 0 0 0 0 1
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn 1 0 0 0 0 0 1
Institute of Human Genetics, Heidelberg University 0 1 0 0 0 0 1
Institute of Human Genetics, University of Goettingen 1 0 0 0 0 0 1
MVZ Medizinische Genetik Mainz 0 0 1 0 0 0 1
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 1 0 0 0 0 0 1
New York Genome Center 1 0 0 0 0 0 1
OLLIN Analises Genomicas, OLLIN 0 0 1 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 1 0 0 0 0 0 1
Servicio Canario de Salud, Hospital Universitario Nuestra Sra. de Candelaria 0 1 0 0 0 0 1
Variantyx, Inc. 1 0 0 0 0 0 1
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 1 0 0 0 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. The submitted information has not been verified. If you have questions about the information contained on this website, please see a health care professional.