ClinVar Miner

Variants studied for Colorectal cancer, hereditary nonpolyposis, type 2

Coded as:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
713 243 383 400 618 1 2100

Gene and significance breakdown #

Total genes and gene combinations: 3
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
MLH1 711 242 382 400 618 1 2096
LRRFIP2, MLH1 2 1 0 0 0 0 3
MSH2 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 54
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Myriad Genetics, Inc. 639 154 27 315 599 0 1734
Baylor Genetics 58 41 248 0 0 0 347
Counsyl 17 14 78 49 4 0 162
Mendelics 1 6 17 36 13 0 73
Illumina Laboratory Services, Illumina 0 0 51 12 5 0 68
Molecular Pathology, Peter Maccallum Cancer Centre 22 7 30 2 0 0 61
KCCC/NGS Laboratory, Kuwait Cancer Control Center 4 0 1 8 19 0 32
OMIM 27 0 3 0 0 0 30
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 2 0 26 1 0 0 29
Institute of Human Genetics, University of Leipzig Medical Center 11 3 4 1 0 0 19
Center for Human Genetics, Inc, Center for Human Genetics, Inc 3 3 7 2 1 0 16
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 10 3 2 0 0 0 15
Neuberg Centre For Genomic Medicine, NCGM 9 1 5 0 0 0 15
MGZ Medical Genetics Center 7 2 5 0 0 0 14
University of Washington Department of Laboratory Medicine, University of Washington 0 11 1 0 0 0 12
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 7 3 1 0 0 0 11
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 2 0 1 2 5 0 10
Human Genetics Bochum, Ruhr University Bochum 6 2 0 0 0 0 8
Helix 0 0 7 0 0 0 7
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 5 0 2 0 0 0 7
Department of Human Genetics, Hannover Medical School 2 1 3 0 0 0 6
Genetics and Molecular Pathology, SA Pathology 4 1 1 0 0 0 6
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 1 5 0 0 0 6
3billion 2 1 1 0 0 0 4
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 3 1 0 0 0 0 4
Genesis Genomics 3 1 0 0 0 0 4
Centre for Mendelian Genomics, University Medical Centre Ljubljana 2 1 0 0 0 0 3
Division of Medical Genetics, University of Washington 1 0 2 0 0 0 3
Genome Diagnostics Laboratory, Amsterdam University Medical Center 0 0 0 0 3 0 3
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 3 0 0 0 0 0 3
Johns Hopkins Genomics, Johns Hopkins University 0 0 2 1 0 0 3
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 0 0 0 0 2 0 2
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 0 2 0 2
Department of Pediatrics, Memorial Sloan Kettering Cancer Center 1 1 0 0 0 0 2
EVOGEN 0 2 0 0 0 0 2
Juno Genomics, Hangzhou Juno Genomics, Inc 1 1 0 0 0 0 2
Molecular Genetics and NGS Laboratory, Hospital Fundacion Valle Del Lili 1 1 0 0 0 0 2
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 0 2 0 0 0 2
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 0 1 1 0 0 0 2
Zotz-Klimas Genetics Lab, MVZ Zotz Klimas 1 0 1 0 0 0 2
Bioscientia Institut fuer Medizinische Diagnostik GmbH, Sonic Healthcare 0 1 0 0 0 0 1
Biotechnology, Institute of Science, Nirma University 1 0 0 0 0 0 1
CENTOGENE GmbH and LLC - Guiding Precision Medicine 0 1 0 0 0 0 1
Clinical Genomics, G42 Labs 1 0 0 0 0 0 1
Department of Medical and Surgical Sciences, University of Bologna 1 0 0 0 0 0 1
Diagnostics Centre, Carl Von Ossietzky University Oldenburg 0 1 0 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 1 0 0 0 0 0 1
Genetic Services Laboratory, University of Chicago 1 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 1 0 0 0 0 1
Institute of Human Genetics, University of Goettingen 0 0 1 0 0 0 1
MVZ Martinsried, Medicover Genetics 1 0 0 0 0 0 1
MVZ Medizinische Genetik Mainz 0 0 1 0 0 0 1
Palindrome, Gene Kavoshgaran Aria 1 0 0 0 0 0 1

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