Submissions for variant NM_032578.4(MYPN):c.2409C>A (p.Ser803Arg)

Minimum review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
		ClinVar version:

Total submissions: 4

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Mayo Clinic Laboratories, Mayo Clinic	RCV001584192	SCV004225257	uncertain significance	not provided	2023-01-27	criteria provided, single submitter	clinical testing	BP4
GeneDx	RCV001584192	SCV001814076	likely benign	not provided	2020-12-08	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000619222	SCV000735870	likely benign	Cardiovascular phenotype	2024-07-05	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Labcorp Genetics (formerly Invitae), Labcorp	RCV000463865	SCV000563298	likely benign	Dilated cardiomyopathy 1KK	2025-01-12	criteria provided, single submitter	clinical testing

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