ClinVar Miner

Submissions for variant NM_004568.6(SERPINB6):c.121G>A (p.Val41Ile)

gnomAD frequency: 0.00057  dbSNP: rs140220538
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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000993037 SCV002437494 likely benign not provided 2025-09-25 criteria provided, single submitter clinical testing
GeneDx RCV000993037 SCV001826209 likely benign not provided 2020-12-16 criteria provided, single submitter clinical testing
Baylor Genetics RCV001335154 SCV001528237 uncertain significance Autosomal recessive nonsyndromic hearing loss 91 2018-02-08 criteria provided, single submitter clinical testing This variant was determined to be of uncertain significance according to ACMG Guidelines, 2015 [PMID:25741868].
Athena Diagnostics RCV000993037 SCV001145735 uncertain significance not provided 2019-08-02 criteria provided, single submitter clinical testing
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine RCV000151842 SCV000200318 likely benign not specified 2018-04-11 criteria provided, single submitter clinical testing p.Val41Ile in exon 2C of SERPINB6: This variant is classified as likely benign b ecause it has been identified in 0.3% (29/10152) of Ashkenazi Jewish chromosomes by the Genome Aggregation Database (gnomAD, http://gnomad.broadinstitute.org; d bSNP rs140220538). ACMG/AMP Criteria applied: BS1
PreventionGenetics, part of Exact Sciences RCV004757137 SCV005351077 likely benign SERPINB6-related disorder 2024-09-06 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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