ClinVar Miner

Submissions for variant NM_003745.2(SOCS1):c.462C>A (p.Tyr154Ter)

dbSNP: rs906125295
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital RCV004673896 SCV005094356 uncertain significance Neoplasm 2025-03-04 criteria provided, single submitter clinical testing
Department Of Pathology & Laboratory Medicine, University Of Pennsylvania RCV003449012 SCV004176807 pathogenic Malignant lymphoma, large B-cell, diffuse 2023-12-04 no assertion criteria provided clinical testing Pre-therapy specimen. This is a truncating mutation predicted to remove last exon; multiple studies show truncating mutations in SOCS1 are inactivating and pathogenic, and have been identified in DLBCL.

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